Innovative Lipid-Lowering Strategies: RNA-Based, Small Molecule, and Protein-Based Therapies [PDF]
Endocrinology and MetabolismDyslipidemia remains a central modifiable risk factor for atherosclerotic cardiovascular disease (ASCVD). While 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, commonly known as statins, as well as ezetimibe, fibrates, and omega-3 ...
Youngwoo Jang +2 more
doaj +2 more sources
Changes in High-Density Lipoprotein Cholesterol and Risks of Cardiovascular Events: A from the PICASSO Trial [PDF]
Journal of Stroke, 2020 Background and purpose Whether pharmacologically altered high-density lipoprotein cholesterol (HDL-C) affects the risk of cardiovascular events is unknown.
Eun-Jae Lee +25 more
doaj +1 more source
Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]
, 2020 Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui +3 more
core +2 more sources
Metabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos
JCI Insight, 2021 Recent in vivo tracer studies demonstrated that targeted mass spectrometry (MS) on the Q Exactive Orbitrap could determine the metabolism of HDL proteins 100s-fold less abundant than apolipoprotein A1 (APOA1).
Sasha A. Singh +6 more
doaj +1 more source
Journal of Lipid Research, 1985 The effect of lipid transfer proteins on the exchange and transfer of cholesteryl esters from rat plasma HDL2 to human very low (VLDL) and low density (LDL) lipoprotein populations was studied.
S Eisenberg
doaj +1 more source
High-Density Lipoprotein Modifications: A Pathological Consequence or Cause of Disease Progression?
Biomedicines, 2020 High-density lipoprotein (HDL) is well-known for its cardioprotective effects, as it possesses anti-inflammatory, anti-oxidative, anti-thrombotic, and cytoprotective properties.
Andrea Bonnin Márquez +2 more
doaj +1 more source
The combined effects of cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people [PDF]
Journal of Cardiovascular and Thoracic Research, 2020 Introduction: Cholesteryl ester transfer protein (CETP) is a key regulating enzyme in the lipid metabolism pathway, and its gene polymorphism may be a candidate for modulating the metabolic responses to dietary intervention.
Nahid Ramezani-Jolfaie +10 more
doaj +1 more source
Journal of Lipid Research, 1992 The access of enzymes and lipid transfer proteins to neutral lipids located predominantly in the core compartment of lipoproteins may be determined to some degree by the solubility of the neutral lipids in the surface monolayer of phospholipid.
QT Li, WH Sawyer
doaj +1 more source
Multiple functions of microsomal triglyceride transfer protein
Nutrition & Metabolism, 2012 Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein capable of transferring neutral lipids between membrane vesicles.
Hussain M Mahmood +4 more
doaj +1 more source
Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. [PDF]
, 1994 Lipoproteins isolated from normal human plasma can bind and neutralize bacterial lipopolysaccharide (LPS) and may represent an important mechanism in host defense against gram-negative septic shock. Recent studies have shown that experimentally elevating
Kane, JP +4 more
core +1 more source