Results 21 to 30 of about 32,808 (269)

Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis.

Circulation, 2020
Background: The high-density lipoprotein (HDL) hypothesis of atherosclerosis has been challenged by clinical trials of cholesteryl ester transfer protein (CETP) inhibitors which failed to show significant reductions in cardiovascular events.
M. Trinder, Yanan Wang, C. M. Madsen, Tatjana Ponomarev, L. Bohunek, Brendan A. Daisely, HyeJin Julia Kong, L. Blauw, B. Nordestgaard, A. Tybjærg-Hansen, M. Wurfel, J. Russell, K. Walley, P. Rensen, J. Boyd, L. Brunham   +15 more
semanticscholar   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Cholesteryl Ester Transfer Protein Inhibitors and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The Cardiology, 2020
Background: Cholesteryl ester transfer protein (CETP) inhibitors increase serum high-density lipoprotein cholesterol (HDL-c) concentration; however, their impact on cardiovascular outcomes is not clear.
Hossein Taheri, K. Filion, S. Windle, P. Reynier, M. Eisenberg   +4 more
semanticscholar   +1 more source

Effects of dalcetrapib in patients with a recent acute coronary syndrome [PDF]

, 2012
In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events.
Abt, Markus, Ballantyne, Christie M., Barter, Philip J., Brumm, Jochen, Chaitman, Bernard R., Colquhoun, David, Holme, Ingar M., Kallend, David, Leiter, Lawrence A., Leitersdorf, Eran, McMurray, John J. V., Mundl, Hardi, Nicholls, Stephen J., Olsson, Anders G., Schwartz, Gregory G., Shah, Prediman K., Tardif, Jean-Claude, The dal-OUTCOMES Investigators, Wright, R. Scott   +18 more
core   +2 more sources

Isolation and characterization of a phospholipid transfer protein (LTP-II) from human plasma.

Journal of Lipid Research, 1988
In this report we have described the purification of a human plasma phospholipid transfer protein, designated LTP-II, which displayed the following characteristics: i) facilitated both the exchange and net mass transfer of lipoprotein phospholipids; ii ...
J H Tollefson, S Ravnik, J J Albers
doaj   +1 more source

Specificity of lipid transfer protein for molecular species of cholesteryl ester.

Journal of Lipid Research, 1988
The capacity of the plasma-derived lipid transfer protein to facilitate the transfer of various cholesteryl ester species has been investigated. Four different molecular species of cholesteryl ester were incorporated into either reconstituted high ...
R E Morton
doaj   +1 more source

Interaction of plasma-derived lipid transfer protein with macrophages in culture

Journal of Lipid Research, 1988
This study investigates the ability of human plasma-derived lipid transfer protein to facilitate lipid transfer to and from intact viable cells in culture.
R E Morton
doaj   +1 more source

Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration [PDF]

, 2017
10.1194/jlr.M073684Journal of Lipid Research5891785 ...
Apte, Rajendra S., Chee, Miao Ling, Cheng, Ching-Yu, Fan, Qiao, Gan, Alfred, Gemmy Cheung, Chui Ming, Khor, Chiea Chuen, Mathur, Ranjana, Tai, E. Shyong, Wong, Tien Yin, Yeo, Ian   +10 more
core   +2 more sources

Inhibition of pancreatic cholesterol esterase reduces cholesterol absorption in the hamster [PDF]

, 2004
BACKGROUND: Pancreatic cholesterol esterase has three proposed functions in the intestine: 1) to control the bioavailability of cholesterol from dietary cholesterol esters; 2) to contribute to incorporation of cholesterol into mixed micelles; and 3) to ...
Contos, Linda M, Deck, Lorraine M, Heidrich, John E, Hunsaker, Lucy A, Vander Jagt, David L   +4 more
core   +2 more sources

High density lipoprotein subfractions isolated by heparin-Sepharose affinity chromatography and their role in cholesteryl ester transfer to very low density lipoproteins.

Journal of Lipid Research, 1981
Normal human plasma HDL was applied to a column of heparin-Sepharose in the presence of MnCl(2) and three fractions were obtained by stepwise elution with increasing NaCl concentrations: a non-retained fraction (NR, 78% of protein) and two retained ...
Y L Marcel, C Vézina, D Emond, R B Verdery, R W Milne   +4 more
doaj   +1 more source