∆4-3-oxo-5β-reductase deficiency: favorable outcome in 16 patients treated with cholic acid [PDF]
Orphanet Journal of Rare Diseases, 2023 Background Oral cholic acid therapy is an effective therapy in children with primary bile acid synthesis deficiencies. Most reported patients with this treatment have 3β-hydroxy-Δ5-C27-steroid oxidoreductase deficiency.
Antoine Gardin +21 more
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Bioassay-Guided Fractionation Leads to the Detection of Cholic Acid Generated by the Rare Thalassomonas sp. [PDF]
Marine Drugs, 2022 Bacterial symbionts of marine invertebrates are rich sources of novel, pharmaceutically relevant natural products that could become leads in combatting multidrug-resistant pathogens and treating disease.
Fazlin Pheiffer +9 more
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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Cholic Acid (MT921) after a Subcutaneous Injection in the Submental Area to Humans [PDF]
Pharmaceuticals, 2021 This study aimed to explore pharmacokinetics, pharmacodynamics, and safety/tolerability of MT921, an injectable cholic acid, after a single subcutaneous administration to healthy volunteers.
Hyewon Chung +6 more
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On the Tensammetric Wave of Cholic Acid
Nippon kagaku zassi, 1967 交流ポーラログラフにより測定されたゴール酸のテンサンメトリー波について検討した。コール酸のテンサンメトリー波はデヒドロコール酸の場合と異なり, 脱着波が二つに分離する現象がみられた。脱着波はコール酸および支持電解質濃度の増加とともに, また温度の低下とともに分離する傾向がみられた。これは吸着イオン間の相互作用によって気相吸着層と凝縮相吸着層との相分離が起り, それらが段階的に脱着するものと解釈された。相分離が起る原因はコール酸イオン内の水酸基の相互反発によるものと考えられた。またコール酸のテンサンメトリー波からミセル限界濃度(CMC)が求められ, その対数と支持電解質濃度の対数との間に直線関係がみられた。水酸化カリウム濃度0.5mol/lにおける濃度-波高関係はLangmuirの吸着等温線型を示し,
Masao Maruyama, Yoshio OKABE
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Induction of hepatic CYP3A4 expression by cholesterol and cholic acid: Alterations of gene expression, microsomal activity, and pharmacokinetics [PDF]
Pharmacology Research & PerspectivesHuman cytochrome P450 3A4 (CYP3A4) is a drug‐metabolizing enzyme that is abundantly expressed in the liver and intestine. It is an important issue whether compounds of interest affect the expression of CYP3A4 because more than 30% of commercially ...
Genki Minegishi +5 more
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Gut microbiota-derived cholic acid mediates neonatal brain immaturity and white matter injury under chronic hypoxia [PDF]
iScienceSummary: Chronic hypoxia, common in neonates, disrupts gut microbiota balance, which is crucial for brain development. This study utilized cyanotic congenital heart disease (CCHD) patients and a neonatal hypoxic rat model to explore the association. Both
Yichen Yan +13 more
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Cholic acid increases plasma cholesterol in Smith-Lemli-Opitz syndrome: A pilot study [PDF]
Molecular Genetics and Metabolism ReportsBackground: Smith-Lemli-Opitz syndrome (SLOS) is an inherited disorder of cholesterol biosynthesis associated with congenital malformations, growth delay, intellectual disability and behavior problems.
Ellen R. Elias +5 more
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PARTIAL OXIDATION OF CHOLIC ACID [PDF]
Journal of Biological Chemistry, 1943 T. F. Gallagher, William P. Long
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Bacterial 7-dehydroxylation of cholic acid and allocholic acid
Journal of Lipid Research, 1969 An obligate anaerobic organism capable of dehydroxylating cholic acid to deoxycholic acid and allocholic acid to allodeoxycholic acid was isolated from feces of the rabbit. It was a member of the bacteroides group (Gram-variable, nonsporulating anaerobes)
Victor Bokkenheuser +2 more
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The effect of cholic acid treatment on the oxidative status of soybean plants [PDF]
Journal of the Serbian Chemical Society, 2009 The objective of this work was to study the effect of treatment of young soybean plants with cholic acid of different concentrations on their oxidative status.
Kevrešan Slavko E. +4 more
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