∆4-3-oxo-5β-reductase deficiency: favorable outcome in 16 patients treated with cholic acid [PDF]
Orphanet Journal of Rare Diseases, 2023 Background Oral cholic acid therapy is an effective therapy in children with primary bile acid synthesis deficiencies. Most reported patients with this treatment have 3β-hydroxy-Δ5-C27-steroid oxidoreductase deficiency.
Antoine Gardin +21 more
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Induction of hepatic CYP3A4 expression by cholesterol and cholic acid: Alterations of gene expression, microsomal activity, and pharmacokinetics [PDF]
Pharmacology Research & PerspectivesHuman cytochrome P450 3A4 (CYP3A4) is a drug‐metabolizing enzyme that is abundantly expressed in the liver and intestine. It is an important issue whether compounds of interest affect the expression of CYP3A4 because more than 30% of commercially ...
Genki Minegishi +5 more
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Nanobiosensor Design to Detect Cholic Acid Using Multiwalled Carbon Nanotube /TiO2 Nanoparticle for 3α-Hydroxysteroid Dehydrogenase Immobilization [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2022 Determination of cholic acid concentration is a useful method to monitor liver diseases. We propose a rapid and simple method for measuring cholic acid.
Emad Mohammad Jassim +4 more
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Bioassay-Guided Fractionation Leads to the Detection of Cholic Acid Generated by the Rare Thalassomonas sp. [PDF]
Marine Drugs, 2022 Bacterial symbionts of marine invertebrates are rich sources of novel, pharmaceutically relevant natural products that could become leads in combatting multidrug-resistant pathogens and treating disease.
Fazlin Pheiffer +9 more
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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Cholic Acid (MT921) after a Subcutaneous Injection in the Submental Area to Humans [PDF]
Pharmaceuticals, 2021 This study aimed to explore pharmacokinetics, pharmacodynamics, and safety/tolerability of MT921, an injectable cholic acid, after a single subcutaneous administration to healthy volunteers.
Hyewon Chung +6 more
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Synthesis of Both Ionic Species of Ammonium Dithiocarbamate Derived Cholic Acid Moieties [PDF]
Molecules, 2011 The reaction of 3-aminopropylamide of cholic acid with CS2 produced a bile acid derivative of dithiocarbamic acid which further formed an ammonium salt with another molecule of 3-aminopropylamide of cholic acid.
Erkki Kolehmainen, Juha Koivukorpi
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Cholic acid–quinoxaline (2/1) [PDF]
Acta Crystallographica Section E Structure Reports Online, 2008 In the title inclusion compound, 2C(24)H(40)O(5)·C(8)H(6)N(2), the unit cell contains two mol-ecules of cholic acid (3α,7α,12α-trihydr-oxy-5β-cholan-24-oic acid) and one mol-ecule of quinoxaline which implies disorder of the quinoxaline in the space group P2(1).
Barbara Wicher, М. Gdaniec
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Journal of Lipid Research, 1979 The cholic acid CoA ligase activity of rat liver was quantitatively inactivated by proteolysis with pronase, chymotrypsin, subtilisin, or proteinase K in intact microsomal vesicles.
M A Polokoff, R A Coleman, R M Bell
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Journal of Lipid Research, 1992 Cholic acid, deoxycholic acid, chenodeoxycholic acid, and ursodeoxycholic acid were purified by a foam fractionation method. Using thermogravimetric analysis, the attached water molecule was found to be completely removed from solids of the latter three ...
Y Moroi, M Kitagawa, H Itoh
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Product Validation and Stability Testing of Pharmacy Compounded Cholic Acid Capsules for Dutch Patients with Rare Bile Acid Synthesis Defects. [PDF]
Pharmaceutics, 2023 Polak Y +5 more
europepmc +3 more sources