Results 11 to 20 of about 5,014,718 (261)

Cholic acid therapy in Zellweger spectrum disorders

Journal of Inherited Metabolic Disease, 2016
AbstractIntroductionZellweger spectrum disorders (ZSDs) are characterized by a failure in peroxisome formation, caused by autosomal recessive mutations in different PEX genes. At least some of the progressive and irreversible clinical abnormalities in patients with a ZSD, particularly liver dysfunction, are likely caused by the accumulation of toxic ...
Frédéric M. Vaz, E. M. Kemper, Ronald J.A. Wanders, Hans R. Waterham, Bart G. P. Koot, Femke C. C. Klouwer, Sacha Ferdinandusse, Marc Engelen, Kiran V. K. Koelfat, Peter L.M. Jansen, Bwee Tien Poll-The, Kevin Berendse, Martin Lenicek, Frank G. Schaap   +13 more
openaire   +5 more sources

Cholic Acid-Based Antimicrobial Peptide Mimics as Antibacterial Agents. [PDF]

Int J Mol Sci, 2022
There is a significant and urgent need for the development of novel antibacterial agents to tackle the increasing incidence of antibiotic resistance. Cholic acid-based small molecular antimicrobial peptide mimics are reported as potential new leads to ...
Wu J, Yu TT, Kuppusamy R, Hassan MM, Alghalayini A, Cranfield CG, Willcox MDP, Black DS, Kumar N.   +8 more
europepmc   +2 more sources

Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal. [PDF]

Cell Stem Cell, 2022
Chen L, Jiao T, Liu W, Luo Y, Wang J, Guo X, Tong X, Lin Z, Sun C, Wang K, He Y, Zhang Y, Xu H, Wang J, Zuo J, Ding Q, He S, Gonzalez FJ, Xie C.   +18 more
europepmc   +2 more sources

Facially Amphiphilic Cholic Acid-Lysine Conjugates as Promising Antimicrobials. [PDF]

ACS Omega, 2020
The emergence of multidrug-resistant microbes is a significant health concern posing a constant need for new antimicrobials. Membrane-targeting antibiotics are promising candidates with reduced ability of microbes to develop resistance.
Singla P, Kaur M, Kumari A, Kumari L, Pawar SV, Singh R, Salunke DB.   +6 more
europepmc   +2 more sources

Effectiveness and Safety of Personalized Cholic Acid Treatment in Patients With Bile Acid Synthesis Defects. [PDF]

J Inherit Metab Dis
ABSTRACT Bile acid synthesis defects (BASDs) comprise a group of rare, often severe, metabolic disorders. Bile acid replacement therapy decreases toxic bile acid intermediates production and improves biochemical profiles, potentially delaying or stabilizing disease progression.
Polak Y, Kemper EM, Engelen M, Klouwer FCC, Berendse K, Vaz FM, Koot BGP, Swart ENL, Hollak CEM.   +8 more
europepmc   +2 more sources

Structure and Dynamics of Cholic Acid and Dodecylphosphocholine−Cholic Acid Aggregates [PDF]

Langmuir, 2010
Bile acids are powerful detergents that emulsify and solubilize lipids, vitamins, cholesterol and other molecules in the biliary tract and intestines. It has long been known that bile acids form soluble mixed micelles with lipids. However, the detailed thermodynamic and structural properties of these micelles are not fully understood.
Lenard M. Lichtenberger, Alemayehu A. Gorfe, Abdallah Sayyed-Ahmad   +2 more
openaire   +3 more sources

Cholic Acid-Peptide Conjugates as Potent Antimicrobials against Interkingdom Polymicrobial Biofilms. [PDF]

Antimicrob Agents Chemother, 2019
Interkingdom polymicrobial biofilms formed by Gram-positive Staphylococcus aureus and Candida albicans pose serious threats of chronic systemic infections due to the absence of any common therapeutic target for their elimination.
Gupta S, Thakur J, Pal S, Gupta R, Mishra D, Kumar S, Yadav K, Saini A, Yavvari PS, Vedantham M, Singh A, Srivastava A, Prasad R, Bajaj A.   +13 more
europepmc   +2 more sources

Cholic Acid-based Delivery System for Vaccine Candidates against Group A Streptococcus. [PDF]

ACS Med Chem Lett, 2019
Peptide-based subunit vaccines require an immunostimulant (adjuvant) and/or delivery system to protect the antigenic peptide from degradation and induce the desired immunity.
Azuar A, Zhao L, Hei TT, Nevagi RJ, Bartlett S, Hussein WM, Khalil ZG, Capon RJ, Toth I, Skwarczynski M.   +9 more
europepmc   +2 more sources

Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy

Hepatology, EarlyView., 2022
Serum bile acid levels predict outcomes in patients with biliary atresia who achieve normalized bilirubin levels after Kasai portoenterostomy. Abstract Background and Aims In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP).
Sanjiv Harpavat, Kieran Hawthorne, Kenneth D. R. Setchell, Monica Narvaez Rivas, Lisa Henn, Charlotte A. Beil, Saul J. Karpen, Vicky L. Ng, Estella M. Alonso, Jorge A. Bezerra, Stephen L. Guthery, Simon Horslen, Kathy M. Loomes, Patrick McKiernan, John C. Magee, Robert M. Merion, Jean P. Molleston, Philip Rosenthal, Richard J. Thompson, Kasper S. Wang, Ronald J. Sokol, Benjamin L. Shneider, for Childhood Liver Disease Research Network (ChiLDReN)   +22 more
wiley   +1 more source

UPLC-QqQ-MS/MS-based Quantitative Analysis on Bile Acid in Hyperthyroidism Rats to Explore the Effects of Ginseng Herbs [PDF]

Zhipu Xuebao, 2023
A method of ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometry (UPLC-QqQ-MS/MS) was developed to determine the contents of deoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, cholic acid, glycinecholic acid ...
LIU Lin-lin, JIN Mo-zhu, DOU De-qiang
doaj   +1 more source