Cholic acid therapy in Zellweger spectrum disorders
Journal of Inherited Metabolic Disease, 2016 AbstractIntroductionZellweger spectrum disorders (ZSDs) are characterized by a failure in peroxisome formation, caused by autosomal recessive mutations in different PEX genes. At least some of the progressive and irreversible clinical abnormalities in patients with a ZSD, particularly liver dysfunction, are likely caused by the accumulation of toxic ...
Berendse, Kevin +13 more
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Gut microbiota-derived cholic acid mediates neonatal brain immaturity and white matter injury under chronic hypoxia [PDF]
iScienceSummary: Chronic hypoxia, common in neonates, disrupts gut microbiota balance, which is crucial for brain development. This study utilized cyanotic congenital heart disease (CCHD) patients and a neonatal hypoxic rat model to explore the association. Both
Yichen Yan +13 more
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Cholic acid increases plasma cholesterol in Smith-Lemli-Opitz syndrome: A pilot study [PDF]
Molecular Genetics and Metabolism ReportsBackground: Smith-Lemli-Opitz syndrome (SLOS) is an inherited disorder of cholesterol biosynthesis associated with congenital malformations, growth delay, intellectual disability and behavior problems.
Ellen R. Elias +5 more
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Cholic Acid-Based Antimicrobial Peptide Mimics as Antibacterial Agents. [PDF]
Int J Mol Sci, 2022 There is a significant and urgent need for the development of novel antibacterial agents to tackle the increasing incidence of antibiotic resistance. Cholic acid-based small molecular antimicrobial peptide mimics are reported as potential new leads to ...
Wu J +8 more
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Preparation of Chenodeoxycholic Acid from Cholic Acid [PDF]
Nature, 1952 KAWAI1 converted cholic acid to chenodeoxycholic acid (3α : 7α-dihydroxycholanic acid, anthropodeoxycholic acid) by Kishner–Wolff reduction of the derived 3 : 7-dihydroxy-12-keto cholanic acid. Plattner and Heusser2 similarly reduced methyl 3 : 7-di-acetoxy-12-keto cholanate.
Ian G. Anderson +3 more
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Journal of Lipid Research, 1991 We previously reported that the 7 alpha-dehydroxylation of cholic acid appears to be carried out by a multi-step pathway in intestinal anaerobic bacteria both in vitro and in vivo.
PB Hylemon +4 more
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Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal. [PDF]
Cell Stem Cell, 2022 Chen L +18 more
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Ophthalmic Diagnosis and Novel Management of Infantile Refsum Disease with Combination Docosahexaenoic Acid and Cholic Acid. [PDF]
Case Rep Ophthalmol Med, 2021 Elghawy O +4 more
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Cholic acid as a treatment for cerebrotendinous xanthomatosis: a comprehensive review of safety and efficacy. [PDF]
Orphanet J Rare DisPasternack G, Courtney J, Kalsi G.
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Bacterial 7-dehydroxylation of cholic acid and allocholic acid
Journal of Lipid Research, 1969 An obligate anaerobic organism capable of dehydroxylating cholic acid to deoxycholic acid and allocholic acid to allodeoxycholic acid was isolated from feces of the rabbit. It was a member of the bacteroides group (Gram-variable, nonsporulating anaerobes)
Victor Bokkenheuser +2 more
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