Results 31 to 40 of about 5,014,718 (261)

Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2016
Farnesoid X receptor (FXR) belongs to the nuclear receptor superfamily with its endogenous ligands bile acids. Mice with whole body FXR deficiency develop liver tumors spontaneously, but the underlying mechanism is unclear.
Bo Kong, Yan Zhu, Guodong Li, Jessica A. Williams, Kyle Buckley, O. Tawfik, J. Luyendyk, G. Guo   +7 more
semanticscholar   +1 more source

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

Advanced Science, EarlyView.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen, Xiaokang Ma, Longlin Zhang, Hao Li, Jichang Zheng, Shengru Wu, Ke Zuo, Yulong Yin, Jing Wang, Bie Tan   +9 more
wiley   +1 more source

Biomolecular Interaction Prediction: The Era of AI

Advanced Science, EarlyView.
This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley   +1 more source

UPLC‐ESI‐QTOF‐MS/MS Profiling, Antioxidant, and Cytotoxicity Potentials of Marrubium vulgare L. Extracts: Experimental Analysis and Computational Validation

Chemistry &Biodiversity, EarlyView.
ABSTRACT Plant extracts are emerging as valuable options for food additives and therapeutic treatments. This study evaluated the phytochemical profile, antioxidant activity, and cytotoxicity of aerial parts of Marrubium vulgare L. crude extract (MVCE) and its subfractions.
Ines El Mannoubi, Nuha M. Alghamdi, Seham H. Bashir, Suada Alsaied Mohamed, Hedia Chaabane, Ashraf N. Abdalla, Majdi Abid, Adel Kadri, Mozaniel Santana de Oliveira   +8 more
wiley   +1 more source

Facilitating the Isolation of Polar Natural Products: Mild 1,1′‐Carbonyldiimidazole‐Enabled Method for Derivatization of Acids and Alcohols

European Journal of Organic Chemistry, EarlyView.
In this work, 1,1′‐carbonyldiimidazole, a relatively inexpensive reagent with inherently low toxicity, is utilized to activate polar natural products containing carboxylic acids and alcohols to enable the formation of less polar species (N‐acylimidazoles and N‐acyloxymidazoles).
Moses M. Mutungi, Curtis C. Ho, Alex C. Bissember, Jason A. Smith   +3 more
wiley   +1 more source

Oat Bran Supplementation Improves Glucose Metabolism, Food Addiction, and Gut Microbiota in Rats With High‐Fat Diet‐Induced Obesity

Food Frontiers, EarlyView.
ABSTRACT Oat bran (OB), a byproduct of the oat milling process, is a nutrient‐dense cereal cultivated in cool, dry mountainous regions and is known for its potential health benefits. To explore its obesity‐alleviating effects and the underlying mechanisms, we examined the influence of OB on glucose metabolism, appetite‐regulating hormones, gut ...
Xue Bai, Meili Zhang, Yakun Zhang, Yuanyuan Zhang, Rui Huo, Qixin Gu, Ying Miao   +6 more
wiley   +1 more source

7-Methyl bile acids: 7 beta-methyl-cholic acid inhibits bacterial 7-dehydroxylation of cholic acid and chenodeoxycholic acid in the hamster.

Journal of Lipid Research, 1987
The effect of dietary 7 beta-methyl-cholic acid [0.075% in rodent chow (6.4 mg/animal per day)] on cholesterol and bile acid metabolism was studied and compared with that of cholic acid in the hamster.
S Kuroki, E H Mosbach, B I Cohen, R J Stenger, C K McSherry   +4 more
doaj  

Metabolism of 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid in normal subjects with an intact enterohepatic circulation

Journal of Lipid Research, 1977
The formation of cholic acid from 3α,7α,12α-trihydroxy-5β-cholestan-26-oic acid (THCA) was studied in two normal subjects. [3H]THCA and [14C]cholic acid were administered intravenously by simultaneous injection and the specific activities (percent ...
R F Hanson, G C Williams
doaj  

Creating Biomimetic Bouligand Architectures for Biomedical and Healthcare Applications

Interdisciplinary Materials, Volume 4, Issue 4, Page 539-567, July 2025.
Hierarchical Bouligand structures, evolved in nature for mechanical/functional advantages, are now replicated via various of strategies, including self‐assembly, biomimetic mineralization, shear brushing, electrostatic spinning, 3D printing, etc. Engineered architectures enable breakthroughs in bone regeneration, tooth repair, body protection, and ...
Hongye Yang, Xinyu Zhang, Shilei Wang, Yize Wang, Rui Xiong, Cui Huang   +5 more
wiley   +1 more source

Effects of fasting on bile acid metabolism and biliary lipid composition in man

Journal of Lipid Research, 1976
The effects of a four to six day fast on gallbladder bile lipid composition, bile acid pool size, bile acid composition, and cholic acid metabolism have been determined in normal human subjects.
W C Duane, R L Ginsberg, L J Bennion
doaj