Results 31 to 40 of about 5,133,102 (254)
Journal of Pediatric Gastroenterology and Nutrition - JPGN, 2020 BACKGROUND In patients with bile acid synthesis disorders (BASD), impairment in the primary bile acid synthetic pathway leads to reduced primary bile acids, upregulated synthesis of cholesterol, and production and accumulation of hepatotoxic atypical ...
J. Heubi, K. Setchell
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Journal of Lipid Research, 1987 The effect of dietary 7 beta-methyl-cholic acid [0.075% in rodent chow (6.4 mg/animal per day)] on cholesterol and bile acid metabolism was studied and compared with that of cholic acid in the hamster.
S Kuroki +4 more
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Journal of Lipid Research, 1977 The formation of cholic acid from 3α,7α,12α-trihydroxy-5β-cholestan-26-oic acid (THCA) was studied in two normal subjects. [3H]THCA and [14C]cholic acid were administered intravenously by simultaneous injection and the specific activities (percent ...
R F Hanson, G C Williams
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Effects of fasting on bile acid metabolism and biliary lipid composition in man
Journal of Lipid Research, 1976 The effects of a four to six day fast on gallbladder bile lipid composition, bile acid pool size, bile acid composition, and cholic acid metabolism have been determined in normal human subjects.
W C Duane, R L Ginsberg, L J Bennion
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Journal of Lipid Research, 1989 12 alpha-Hydroxy-3-oxo-4-cholenoic acid coupled to an adenosine nucleotide has been shown to be a metabolite of cholic acid in the intestinal anaerobic bacteria, Eubacterium species VPI 12708 (1987. J. Biol. Chem.
I Björkhem +3 more
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Journal of Traditional Chinese Medical Sciences, 2023 Objective: To investigate the pharmacological action and mechanism of cholic acid derivatives in traditional Chinese medicine (TCM) based on the regulation of gene expression. Methods: Genome-wide gene expression profiles of Michigan Cancer Foundation-7 (
Yongchun Huang +5 more
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7alpha-Dehydroxylation of cholic acid and chenodeoxycholic acid by Clostridium leptum.
Journal of Lipid Research, 1979 The rate of 7alpha-dehydroxylation of primary bile acids was quantitatively measured radiochromatographically in anaerobically washed whole cell suspensions of Clostridium leptum.
E J Stellwag, P B Hylemon
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Screening the binding affinity of bile acid derivatives for the glucocorticoid receptor ligand-binding domain [PDF]
Journal of the Serbian Chemical Society, 2023 The necessity of anti-inflammatory drugs such as glucocorticoids has been evident during the COVID-19 pandemic. Glucocorticoids, are the standard therapy for the treatment of moderate and severe COVID-19 patients.
Bjedov Srđan +7 more
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Journal of Lipid Research, 1979 Side chain oxidation and cleavage of precursors in cholic acid synthesis is thought to involve initial hydroxylation at either position 25 or 26 of the side chain. Therefore, the conversion of 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 26-tetrol and 5
R F Hanson, A B Staples, G C Williams
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Journal of Lipid Research, 1981 A new method is described for measuring the cholic acid turnover and pool size by a single duodenal intubation technique. The method is based on determination in a single bile sample of the ratio of the specific activities of [14C]cholic acid and [3H ...
G Vantrappen, P Rutgeerts, Y Ghoos
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