Results 11 to 20 of about 1,083,054 (280)

Role of choline deficiency in the Fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet. [PDF]

PLoS ONE, 2013
Though widely employed for clinical intervention in obesity, metabolic syndrome, seizure disorders and other neurodegenerative diseases, the mechanisms through which low carbohydrate ketogenic diets exert their ameliorative effects still remain to be ...
Rebecca C Schugar, Xiaojing Huang, Ashley R Moll, Elizabeth M Brunt, Peter A Crawford   +4 more
doaj   +2 more sources

Choline Deficiency Drives the Inflammation–Fibrosis Cascade: A Spatiotemporal Atlas of Hepatic Injury from Weeks 6 to 10 [PDF]

Antioxidants
Metabolic dysfunction-associated steatotic liver disease (MASLD) is strongly linked to systemic metabolic disturbances and features a lipid-driven cascade that promotes hepatic inflammation and fibrosis.
Shang Li, Guoqiang Zhang, Xiaohong Li, Xu Zhao, Axi Shi, Qingmin Dong, Changpeng Chai, Xiaojing Song, Yuhui Wei, Xun Li   +9 more
doaj   +2 more sources

Effects of choline deficiency and supplementation on lipid droplet accumulation in bovine primary liver cells in vitro [PDF]

Journal of Dairy Science, 2023
: Rumen-protected choline (RPC) supplementation in the periparturient period has in some instances prevented and alleviated fatty liver disease in dairy cows. Mechanistically, however, it is unclear how choline prevents the accumulation of lipid droplets
Wenyan Lu, Jingna Yang, Mingyue Hu, Kai Zhong, Yueying Wang, Yanbin Yang, Juan J. Loor, Guoyu Yang, Liqiang Han   +8 more
doaj   +2 more sources

Dietary choline deficiency aggravated the intestinal apoptosis in association with the MAPK signalling pathways of juvenile grass carp (Ctenopharyngodon idella)

, 2020
To investigate the effects and potential mechanisms of apoptosis in the intestines of juvenile grass carp (Ctenopharyngodon idella) for dietary choline, fish were fed different choline-containing diets (142.2, 407.4, 821.6, 1215.8, 1589.3, and 1996.6 mg ...
Zehong Yuan, Lin Feng, Wei‐Dan Jiang, Pei Wu, Yang Liu, Sheng‐Yao Kuang, Ling Tang, Xiao‐Qiu Zhou   +7 more
openalex   +3 more sources

Aberrant Estrogen Regulation of PEMT Results in Choline Deficiency-associated Liver Dysfunction [PDF]

Journal of Biological Chemistry, 2010
When dietary choline is restricted, most men and postmenopausal women develop multiorgan dysfunction marked by hepatic steatosis (choline deficiency syndrome (CDS)). However, a significant subset of premenopausal women is protected from CDS.
Mary Resseguie, Kerry-Ann da Costa, Joseph A. Galanko, Mukund Patel, Ian J. Davis, Steven H. Zeisel   +5 more
openalex   +2 more sources

Choline-deficiency fatty liver: impaired release of hepatic triglycerides

Journal of Lipid Research, 1968
After intravenous injection of palmitate-1-14C to rats fed a choline-deficient (CD) or choline-supplemented (CS) diet for 15-18 hr, liver triglycerides became labeled very rapidly.
B. Lombardi, P. Pani, F.F. Schlunk
doaj   +2 more sources

Choline in Adolescent Pregnancy: The Impact on Fetal Brain Development and Long-Term Cognitive Outcomes of Offspring [PDF]

Medicina
Pregnancy in adolescence represents a major nutritional challenge, with competing demands between maternal development and fetal growth. Choline is the essential nutrient with a critical role for fetal brain development and exhibits distinct metabolic ...
Abdul Jabar Khudor, Marius Alexandru Moga, Oana Gabriela Dimienescu, Andrada Camelia Nicolau, Cristian Andrei Arvătescu, Mircea Daniel Hogea, Natalia Ciobanu   +6 more
doaj   +2 more sources

TNAP dephosphorylates phosphocholine and phosphoethanolamine and participates in triglyceride transport from the liver to the bloodstream [PDF]

Communications Biology
Tissue-nonspecific alkaline phosphatase (TNAP) is primarily known for its role in skeletal mineralization, through the hydrolysis of inorganic pyrophosphate (PPi).
Eva Drevet Mulard, Iliass Imam, Pierre-Damien Coureux, Anne Briolay, Laurence Bessueille, Antoine Tarby, Stéphane Balayssac, Sonoko Narisawa, Felix Lecornu, Véronique Gilard, Sébastien Violot, Jose Luis Millan, Gilles Jean Philippe Rautureau, Lionel Ballut, David Magne   +14 more
doaj   +2 more sources

High intake of n-6 polyunsaturated fatty acid exacerbates non-alcoholic steatohepatitis by the involvement of multiple metabolic pathways [PDF]

Frontiers in Nutrition
Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, inflammation, and hepatocyte damage. A Western-style diet characterized by excessive n-6 polyunsaturated fatty acid (n-6 PUFA) intake, which is metabolized to pro-inflammatory ...
Jian-Tong, Meng-Ting Zhou, Xiang-Zhun Song, Liu Yang, Yu-Hui Fang, Lan Liu, Jing-Shu Cui, Xiao-Chen Lu, Hai-Yang Zhu, Ying-Bin Jin, Hong-Mei Han   +10 more
doaj   +2 more sources

The Importance of Gut Microbiota on Choline Metabolism in Neurodegenerative Diseases

Biomolecules
The gut microbiota is a complex ecosystem that influences digestion, immune response, metabolism, and has been linked to health and well-being. Choline is essential for neurotransmitters, lipid transport, cell-membrane signaling, methyl-group metabolism ...
Majid Eslami, Farnaz Alibabaei, Ali Babaeizad, Seyedeh Zahra Banihashemian, Mahdi Mazandarani, Aref Hoseini, Mohammad Ramezankhah, Valentyn Oksenych, Bahman Yousefi   +8 more
doaj   +2 more sources