Results 41 to 50 of about 167,062 (267)

Spasmolytic activity of Aquilariae Lignum Resinatum extract on gastrointestinal motility involves muscarinic receptors, calcium channels and NO release

Pharmaceutical Biology, 2018
Context: Aquilariae Lignum Resinatum (ALR), the dry rhizome of Aquilaria agallocha R. (Thymelaeaeeae), has been widely used to treat emesis, stomachache and gastrointestinal dysfunction. Objective: This study evaluates the effects of ALR methanol extract
Huimin Li, Yanfei Qu, Jiawei Zhang, Jingze Zhang, Wenyuan Gao   +4 more
doaj   +1 more source

Targeted Delivery of CNS‐Specific Hesperidin as a Leptin Sensitizer for Treating Obesity‐Associated Sleep‐Disordered Breathing

Advanced Science, EarlyView.
Hesperidin nanoparticles (HE NPs) effectively combat obesity and sleep‐disordered breathing in mice by enhancing leptin sensitivity. Through suppression of hypothalamic endoplasmic reticulum stress and restoration of leptin signaling, HE NPs promote weight loss and improve breathing during sleep.
Yixuan Wang, Qingyu Zhao, Qingfeng Zhang, Xiaofeng Wu, Xu Liu, Shujuan Wu, Hailing Liu, Beini Zhou, Shiqian Zha, Dong Zhao, Gang Deng, Ke Hu   +11 more
wiley   +1 more source

Stability in the Face of Change: Lifelong Experience-Dependent Plasticity in the Sensory Cortex

Frontiers in Cellular Neuroscience, 2020
Plasticity is a fundamental property of the nervous system that enables its adaptations to the ever-changing environment. Heightened plasticity typical for developing circuits facilitates their robust experience-dependent functional maturation.
Adema Ribic
doaj   +1 more source

Phospholipid Remodeling and Tri‐Layer Membrane Reconstruction Mediate Cognitive Effects of Humanized Milk Fat Globules in Neonatal Rats

Advanced Science, EarlyView.
Humanized milk fat globules (MFG) mimic the native composition and structure of human milk, achieved through remodeling of milk fat globule membrane phospholipid composition and reconstruction of the tri‐layer membrane structure. These humanized MFG exhibit improved structural stability and digestibility, and enhance neurodevelopment in formula‐fed rat
Shaolei Wang, Fengzhi Qiao, Jian He, Jianxin Fu, Tongjie Liu, Huaxi Yi, Qinghai Sheng, Lanwei Zhang, Kai Lin   +8 more
wiley   +1 more source

New Insights into the Development of Donepezil-Based Hybrid and Natural Molecules as Multi-Target Drug Agents for Alzheimer’s Disease Treatment

Molecules
Alzheimer’s disease (AD) involves a complex pathophysiology with multiple interconnected subpathologies, including protein aggregation, impaired neurotransmission, oxidative stress, and microglia-mediated neuroinflammation.
Violina T. Angelova, Boris P. Stoyanov, Rumyana Simeonova   +2 more
doaj   +1 more source

A cell autonomous torsinA requirement for cholinergic neuron survival and motor control

eLife, 2018
Cholinergic dysfunction is strongly implicated in dystonia pathophysiology. Previously (Pappas et al., 2015;4:e08352), we reported that Dlx5/6-Cre mediated forebrain deletion of the DYT1 dystonia protein torsinA (Dlx-CKO) causes abnormal twisting and ...
Samuel S Pappas, Jay Li, Tessa M LeWitt, Jeong-Ki Kim, Umrao R Monani, William T Dauer   +5 more
doaj   +1 more source

Neural Response Reliability as a Marker of the Transition of Neural Codes along Auditory Pathways

Advanced Science, EarlyView.
Decoding sound from neural activity in mice reveals a striking shift in how the brain encodes sound: from precise but redundant timing codes in early auditory areas to efficient, synergistic rate‐based codes in the cortex. This transformation highlights a robust neural strategy for turning complex acoustic input into coherent perception across the ...
Alexa Buck, Typhaine Dupont, Rupert Andrews Cavanagh, Olivier Postal, Jérôme Bourien, Jean‐Luc Puel, Nicolas Michalski, Boris Gourévitch   +7 more
wiley   +1 more source

Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins

Advanced Science, EarlyView.
As newly emerged optogenetic tools, potassium channelrhodopsins (KCRs) can drift from inhibition to activation during illumination as K⁺ selectivity declines. It is shown that both the absolute K⁺/Na⁺ permeability ratio and its stability over time govern this drift, identify KCR1‐C29D as a reliably inhibitory variant, and outline design principles for ...
Xiao Duan, Chong Zhang, Stanislav Ott, Zhiyi Zhang, Christiane Ruse, Sven Dannhäuser, Robert Jacobi, Nadine Ehmann, Divya Sachidanandan, Georg Nagel, Manfred Heckmann, Robert J. Kittel, Alexander Gottschalk, Adam Claridge‐Chang, Shiqiang Gao   +14 more
wiley   +1 more source

Cholinergic stimulation stabilizes TRPM4 in the plasma membrane of cortical pyramidal neurons

Frontiers in Cell and Developmental Biology
TRPM4 is a calcium activated non-selective cation channel, impermeable to Ca2+, in neurons it has been implicated in the regulation of the excitability and in the persistent firing.
Paula Leyton, Denise Riquelme, Francisco A. Peralta, Franco D. Navarro, Elias Leiva-Salcedo   +4 more
doaj   +1 more source

Autonomic regulation of heart rate during specific dynamic action associated with digestion in the bullfrog Lithobates catesbeianus

Zoologia (Curitiba), 2015
Feeding causes a substantial rise in the aerobic metabolism of all vertebrates, which is met by a rise in heart rate to secure adequate oxygen delivery, as well as intestinal nutrient absorption and transport between organs.
Débora Claësson, Augusto Shinya Abe, Tobias Wang   +2 more
doaj   +1 more source