Results 41 to 50 of about 285,894 (338)

ENaC in Cholinergic Brush Cells

Frontiers in Cell and Developmental Biology, 2018
Cholinergic polymodal chemosensory cells in the mammalian urethra (urethral brush cells = UBC) functionally express the canonical bitter and umami taste transduction signaling cascade. Here, we aimed to determine whether UBC are functionally equipped for
Chrissy Kandel, Patricia Schmidt, Alexander Perniss, Maryam Keshavarz, Paul Scholz, Sabrina Osterloh, Mike Althaus, Wolfgang Kummer, Klaus Deckmann   +8 more
doaj   +1 more source

The Autonomic Nervous System Pulls the Strings to Coordinate Circadian HSC Functions

Frontiers in Immunology, 2020
As for many other adult stem cells, the behavior of hematopoietic stem and progenitor cells (HSPCs) is subjected to circadian regulatory patterns. Multiple HSPC functions, such as proliferation, differentiation or trafficking exhibit time-dependent ...
Andrés García-García, Simón Méndez-Ferrer, Simón Méndez-Ferrer, Simón Méndez-Ferrer   +3 more
doaj   +1 more source

Cholinergic Denervation Patterns Across Cognitive Domains in Parkinson's Disease

Movement Disorders, 2020
The cholinergic system plays a key role in cognitive impairment in Parkinson's disease (PD). Previous acetylcholinesterase positron emission tomography imaging studies found memory, attention, and executive function correlates of global cortical ...
S. van der Zee, M. Müller, P. Kanel, T. van Laar, N. Bohnen   +4 more
semanticscholar   +1 more source

A continuum model for the dynamics of the phase transition from slow-wave sleep to REM sleep [PDF]

, 2010
Previous studies have shown that activated cortical states (awake and rapid eye-movement (REM) sleep), are associated with increased cholinergic input into the cerebral cortex.
Li, Xiaoli, Sleigh, James W., Steyn-Ross, D. Alistair, Steyn-Ross, Moira L., Voss, Logan J., Wilson, Marcus T.   +5 more
core   +2 more sources

Cholinergic Control of Inflammation, Metabolic Dysfunction, and Cognitive Impairment in Obesity-Associated Disorders: Mechanisms and Novel Therapeutic Opportunities

Frontiers in Neuroscience, 2019
Obesity and obesity-associated disorders have become world-wide epidemics, substantially increasing the risk of debilitating morbidity and mortality.
Eric H. Chang, Eric H. Chang, Sangeeta S. Chavan, Sangeeta S. Chavan, Valentin A. Pavlov, Valentin A. Pavlov   +5 more
doaj   +1 more source

Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement

Biomolecules, 2019
Alzheimer’s disease, a major and increasing global health challenge, is an irreversible, progressive form of dementia, associated with an ongoing decline of brain functioning.
G. Stanciu, A. Luca, R. Rusu, V. Bild, S. B. Beschea Chiriac, C. Solcan, W. Bild, D. Ababei   +7 more
semanticscholar   +1 more source

Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies

Nature Communications, 2020
Assimilation of novel strategies into a consolidated action repertoire is a crucial function for behavioral adaptation and cognitive flexibility. Acetylcholine in the striatum plays a pivotal role in such adaptation, and its release has been causally ...
Daniel Dautan, I. Huerta-Ocampo, Nadine K. Gut, M. Valencia, Krishnakanth Kondabolu, Yuwoong Kim, Todor V. Gerdjikov, J. Mena-Segovia   +7 more
semanticscholar   +1 more source

Dysregulated homeostasis of acetylcholine levels in immune cells of RR-multiple sclerosis patients [PDF]

, 2016
Multiple sclerosis (MS) is characterized by pro-inflammatory cytokine production. Acetylcholine (ACh) contributes to the modulation of central and peripheral inflammation.
Biagioni, Stefano, Costantini, Erica, DI BARI, Maria, Di Nicola, Marta, D’Angelo, Chiara, Galizia, Sabrina, Gasperini, Claudio, Orlando, Viviana, Porfilio, Italo, Reale, Marcella, Ruggieri, Serena, Tata, Ada Maria   +11 more
core   +2 more sources

Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency

eLife, 2020
The basolateral amygdala (BLA) is critical for associating initially neutral cues with appetitive and aversive stimuli and receives dense neuromodulatory acetylcholine (ACh) projections.
Richard B Crouse, Kristen Kim, Hannah M Batchelor, Eric M Girardi, Rufina Kamaletdinova, Justin Chan, Prithviraj Rajebhosale, Steven T Pittenger, Lorna W Role, David A Talmage, Miao Jing, Yulong Li, Xiao-Bing Gao, Yann S Mineur, Marina R Picciotto   +14 more
doaj   +1 more source

Simultaneous release of glutamate and acetylcholine from single magnocellular "cholinergic" basal forebrain neurons [PDF]

, 2006
Basal forebrain (BF) neurons provide the principal cholinergic drive to the hippocampus and cortex. Their degeneration is associated with the cognitive defects of Alzheimer's disease. Immunohistochemical studies suggest that some of these neurons contain
Abogadie, FC, Allen, TGJ, Brown, DA
core   +1 more source