Results 71 to 80 of about 167,062 (267)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Progress of non‐motor symptoms in early‐onset Parkinson's disease

Ibrain, EarlyView.
This study reviews the research progress related to non‐motor symptoms (NMS) in patients with early onset Parkinson's disease (EOPD), including neuropsychiatric symptoms, autonomic dysfunction, sleep disorders, and sensory disorders and also summarizes the characteristics of NMS in the genetic form of Parkinson's disease (PD).
Fanshi Zhang, Aidi Luo, Shusheng Liao, Mei Liu, Jun Zhang, Zucai Xu   +5 more
wiley   +1 more source

SOCS7-Derived BC-Box Motif Peptide Mediated Cholinergic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells [PDF]

, 2023
Hiroshi Kanno, Shutaro Matsumoto, Tetsuya Yoshizumi, Kimihiro Nakahara, Masamichi Shinonaga, Atsuhiko Kubo, Satoshi Fujii, Yasuyuki Ishizuka, Masaki Tanaka, Masamitsu Ichihashi, Hidetoshi Murata   +10 more
openalex   +1 more source

Perturbed synaptic adhesion molecules signaling in neurodevelopmental disorders: The impact of metal neurotoxicity

Ibrain, EarlyView.
Synaptic adhesion molecules (SAM) are essential for the formation, maturation, function, plasticity, and assembly of synaptic connections, all critical for normal neurodevelopment. Excessive exposure to neurotoxic metals during development could disrupt the developing brain and potentially lead to neurodevelopmental disorders (NDDs).
Toheeb O. Oyerinde, Victor E. Anadu, Tobiloba S. Olajide, Ileje I. Ukwubile, Olayemi K. Ijomone, Kingsley A. Iteire, Michael Aschner, Omamuyovwi M. Ijomone   +7 more
wiley   +1 more source

Innovative Therapy for Alzheimer’s Disease-With Focus on Biodelivery of NGF

Frontiers in Neuroscience, 2019
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with abnormal protein modification, inflammation and memory impairment. Aggregated amyloid beta (Aβ) and phosphorylated tau proteins are medical diagnostic features.
Sumonto Mitra, Homira Behbahani, Maria Eriksdotter, Maria Eriksdotter   +3 more
doaj   +1 more source

Functional neurochemical imaging of the human striatal cholinergic system during reversal learning [PDF]

, 2017
Tiffany Bell, Michael Lindner, Paul G. Mullins, Anastasia Christakou   +3 more
openalex   +1 more source

FIGO committee opinion: Environmental drivers of obstetric health and early childhood development

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Environmental exposures are increasingly recognized as critical, yet underappreciated, determinants of reproductive, perinatal, and early childhood health. Developed through a structured consensus process and grounded in systematic evidence review, this FIGO committee opinion provides a comprehensive synthesis of the current evidence linking ...
Nathaniel DeNicola, Emily Lasher, Abena BakenRa, Rashmi Joglekar, Jun Zhang, Annette Hasenburg, Krishnendu Gupta, Ditas Decena, Francisco Edna, David Graham, Edward Morris, Blami Dao, Tracey Woodruff   +12 more
wiley   +1 more source

Cholinergic modulation during acquisition of olfactory fear conditioning alters learning and stimulus generalization in mice [PDF]

, 2012
Eloísa Pavesi, Allison Gooch, Elizabeth Lee, Max L. Fletcher   +3 more
openalex   +1 more source

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In Vitro

Biomolecules & Biomedicine, 2006
Research was done on pharmacological-physiological development of the bronchial receptor system on the smooth muscles of trachea in the newborn children, alive-born and stillborn children.
Aziz Šukalo, Hilmi Islami, Ragib Shabani, Hilmi Dauti, Skender Kutllovci, Bashkim Kastrati   +5 more
doaj   +1 more source