Results 111 to 120 of about 3,652,668 (207)

The activation of glial cells in the medulla visceral zone impairs synaptic plasticity and promotes inflammation and immune disorders in sepsis

Translational Neuroscience
Sepsis elicits neuroinflammation in the medullary visceral zone (MVZ), which disrupts the cholinergic anti-inflammatory pathway (CAP). However, the underlying mechanisms and translational therapeutic potential remain poorly defined.
Wang Jianjian, Wang Lizhi, Jiang Weiwei, Zhu Lu, Li Hongbing   +4 more
doaj   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Immunomodulation through the anti-inflammatory cholinergic pathway: impact on innate and acquired immunity in transplantation

, 2015
Up to now, solid organ transplantation remains the ultimate life-saving treatment for end-stage organ failure. However, transplantation could be complicated by allograft rejection wherein inflammation plays a pivotal role.
Sadis, Claude
core  

Inflammatory activation and cholinergic anti-inflammatory system in eating disorders

, 2013
Dysfunctional serotoninergic regulation and hypothalamic-pituitary-adrenal (HPA) axis overreactivity have been consistently reported in research studies with eating disorders (ED).
Rodríguez, Alberto, Carrasco Perera, José Luis, Leza Cerro, Juan Carlos, Güemes, Itziar, Díaz Marsa, Marina Francisca, Mac-Dowell Mata, Karina Soledad   +5 more
core   +1 more source

α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect. [PDF]

J Neuroinflammation, 2023
Liu H, Zhang X, Shi P, Yuan J, Jia Q, Pi C, Chen T, Xiong L, Chen J, Tang J, Yue R, Liu Z, Shen H, Zuo Y, Wei Y, Zhao L.   +15 more
europepmc   +1 more source

Peripheral non‐invasive focused ultrasound alleviates constipation by reducing gastrointestinal inflammation

Experimental Physiology, EarlyView.
Abstract Constipation affects approximately 20% of the US population, with diverse treatment options available due to the unclear onset and causes of the condition. Recently, focused ultrasound (FUS) has been proposed as a novel, non‐invasive peripheral neuromodulatory treatment that may reduce this inflammation.
Dia Shah, Kainat Akhtar, Dev Dwivedi, Amal Siddiqui, Griffin Haggas, Nicole Forman, Tatiana Gervase, Yifan Kao, John Chen, Julia Brzac, Eric Molho, Damian Shin   +11 more
wiley   +1 more source

Plant‐protein supplementation improves thermoregulatory responses and ameliorates markers of intestinal damage during exercise in the heat

Experimental Physiology, EarlyView.
Abstract Exercise in the heat often causes gastrointestinal (GI) disturbances, which can impair performance. Single amino acid supplementation can attenuate gut damage and enhance exercise tolerance; however, the effectiveness of innate amino acid blends from plant‐based proteins remains underexplored.
Robyn Aitkenhead, Mark Waldron, Gillian E. Conway, Katy Horner, Shane M. Heffernan   +4 more
wiley   +1 more source

Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway. [PDF]

Signal Transduct Target Ther, 2022
Zhang X, Wei X, Deng Y, Yuan X, Shi J, Huang W, Huang J, Chen X, Zheng S, Chen J, Chen K, Xu R, Wang H, Li W, Li S, Yi H, Xiang AP.   +16 more
europepmc   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Median nerve stimulation elevates ventricular fibrillation threshold via the cholinergic anti-inflammatory pathway in myocardial infarction canine model. [PDF]

Front Cardiovasc Med, 2022
Wang X, Qian Y, Yao Y, Wang Y, Zhang Y, Zhang S, Zhao Q.   +6 more
europepmc   +1 more source