Results 111 to 120 of about 126,705 (239)

Evolving treatments for Sjögren disease: current approaches and emerging targets

Internal Medicine Journal, EarlyView.
Abstract Sjögren disease (SjD) is a prevalent systemic autoimmune condition characterised by exocrine gland dysfunction, systemic inflammation and heterogeneous organ involvement. Current management remains largely symptomatic, with no approved disease‐modifying therapies available and substantial unmet clinical need. However, advances in understanding
Mansi Bhurani, Adrian Y. S. Lee, Maureen Rischmueller, Alberta Hoi   +3 more
wiley   +1 more source

Activation of Cholinergic Anti-Inflammatory Pathway in Peripheral Immune Cells Involved in Therapeutic Actions of α-Mangostin on Collagen-Induced Arthritis in Rats [Corrigendum]

Drug Design, Development and Therapy, 2020
Yin Q, Wu Y, Pan S, et al. Drug Des Devel Ther.  2020;14:1983– 1993. The authors have advised the representative images for histological examination of the CIA and MG groups in Figure 1B, page 1987, are identical.
Yin Q, Wu Y, Pan S, Wang D, Tao M, Pei W, Zuo J   +6 more
doaj  

Berberine Ameliorates Spatial Learning Memory Impairment and Modulates Cholinergic Anti-Inflammatory Pathway in Diabetic Rats

Frontiers in Pharmacology, 2019
Background: Cognitive impairment caused by diabetes has been recognized. Berberine is well known for its resistance to peripheral lesions, but it is rarely used for the treatment of spatial learning and memory caused by diabetes.
Kaifu Wang, Qingjie Chen, Ning-hua Wu, Yong Li, Ruyi Zhang, Jiawen Wang, Di Gong, Xin Zou, Chao Liu, Juan Chen   +9 more
semanticscholar   +1 more source

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran, Matjaž Fležar, Manuel Pedro Pereira   +2 more
wiley   +1 more source

Cardiopulmonary Arrest and Resuscitation Disrupts Cholinergic Anti-Inflammatory Processes: A Role for Cholinergic α7 Nicotinic Receptors

, 2011
Cardiac arrest is a leading cause of death worldwide. While survival rates following sudden cardiac arrest remain relatively low, recent advancements in patient care have begun to increase the proportion of individuals who survive cardiac arrest. However,
Holly M. Brothers, John S. Morris, Yousef Al-Abed, Zachary M. Weil, Valentin A. Pavlov, Ning Zhang, Greg J. Norman, Kate Karelina, Gary L. Wenk, A. Courtney DeVries, Kevin J. Tracey   +10 more
core   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Role of cholinergic anti-inflammatory pathway in regulating host response and its interventional strategy for inflammatory diseases

, 2009
The cholinergic anti-inflammatory pathway (CAP) is a neurophysiological mechanism that regulates the immune system. The CAP inhibits inflammation by suppressing cytokine synthesis via release of acetylcholine in organs of the reticuloendothelial system ...
YAO, Yong-ming, ZHOU, Rong-bin, WANG, Da-wei   +2 more
core   +1 more source

GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms

Obesity Reviews, EarlyView.
ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani, Tzu‐Wen L. Cross, Erica de Jong, Emily S. Glover, Ivan D. Mendoza, Mojisola Adisa, Keigo Tomoo, Xinyi Zhou, Richard D. Mattes   +8 more
wiley   +1 more source

Activation of Cholinergic Anti-Inflammatory Pathway in Peripheral Immune Cells Involved in Therapeutic Actions of α-Mangostin on Collagen-Induced Arthritis in Rats

Drug Design, Development and Therapy, 2020
Qin Yin,1,* Yi-jin Wu,1,* Shu Pan,1 Dan-dan Wang,2,3 Meng-qing Tao,2,3 Wei-ya Pei,2 Jian Zuo2– 4 1Department of Pharmacy, The Second Affiliated Hospital of Wannan Medical College, Wuhu 241000, People’s Republic of China; 2Department of ...
Yin Q, Wu Y, Pan S, Wang D, Tao M, Pei W, Zuo J   +6 more
doaj  

Electroacupuncturing At Zusanli Point (St36) Attenuates Pro-Inflammatory Cytokine Release And Organ Dysfunction By Activating Cholinergic Anti-Inflammatory Pathway In Rat With Endotoxin Challenge

, 2014
Background: It is considered that the pathogenesis is closely related to an excessive production of pro-inflammatory cytokines caused by bacterial toxins and an imbalance between pro-inflammatory and anti-inflammatory mediatorsMaterials and Methods: This
Song, Q, Song, Qi, Lv, Yi, Wang, H, Wang, Haibin, Hu, Sen, Sheng, W, Shi, X, Shi, Xian, Sheng, Ziyong, Sheng, Z, Hu, S, Lv, Y, Sheng, Wei   +13 more
core   +1 more source