Results 121 to 130 of about 126,705 (239)

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Acute pain transfusion reaction in a patient with thalassemia: In‐depth characterization of short‐ and long‐term phenotypes

Transfusion, EarlyView.
Abstract Background Acute pain transfusion reaction (APTR) is a rare, under‐recognized condition of unknown etiology. It can cause significant distress in recipients, necessitating symptomatic management and, occasionally, hospitalization. Study Design and Methods Here, we present an APTR event in an adult subject with transfusion‐dependent thalassemia
Georgia Tzafa, Sophia Delicou, Ioanna Barla, Konstantina Theocharaki, Aggeliki Kondi, Athanassios D. Velentzas, Nikolaos Simantiris, Elli‐Anna Stylianaki, George Mpekoulis, Efthymia Pavlou, Niki Vassilaki, Ioannis V. Kostopoulos, Aikaterini Xydaki, Efrosyni Nomikou, Ioanna‐Katerina Aggeli, Nikolaos Thomaidis, Evangelos Gikas, Martina Samiotaki, Jerome Zoidakis, Constantina Politis, Marianna H. Antonelou   +20 more
wiley   +1 more source

Plant‐protein supplementation improves thermoregulatory responses and ameliorates markers of intestinal damage during exercise in the heat

Experimental Physiology, EarlyView.
Abstract Exercise in the heat often causes gastrointestinal (GI) disturbances, which can impair performance. Single amino acid supplementation can attenuate gut damage and enhance exercise tolerance; however, the effectiveness of innate amino acid blends from plant‐based proteins remains underexplored.
Robyn Aitkenhead, Mark Waldron, Gillian E. Conway, Katy Horner, Shane M. Heffernan   +4 more
wiley   +1 more source

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

Immunomodulation through the anti-inflammatory cholinergic pathway: impact on innate and acquired immunity in transplantation

, 2015
Up to now, solid organ transplantation remains the ultimate life-saving treatment for end-stage organ failure. However, transplantation could be complicated by allograft rejection wherein inflammation plays a pivotal role.
Sadis, Claude
core  

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Retracted: Association of the Cholinergic Anti-Inflammatory Pathway Activity with Proinflammatory Factors and Prognosis of Patients with Acute Respiratory Distress Syndrome. [PDF]

Evid Based Complement Alternat Med, 2023
And Alternative Medicine EC.
europepmc   +1 more source

Research progress on acupuncture in multi-target synergistic regulation of immune-inflammatory homeostasis in chronic obstructive pulmonary disease

针刺研究
The pathological development of chronic obstructive pulmonary disease （COPD） is closely related to the imbalance of immune-inflammatory homeostasis， mainly involving the dysregulation of T helper （Th） cell subset homeostasis， imbalance of inflammatory ...
WANG Jia-xuan, SHANG Xiao-long, XIA Hong-yan, YI Zheng-heng, GUO Jun-cheng⁵   +4 more
doaj   +2 more sources

In vivo function of NGF/TrkA signaling in the cholinergic neurons of the murine basal forebrain [PDF]

, 2005
The neurotrophins are a family of secreted proteins that potently regulate diverse neuronal responses. The neurotrophin nerve growth factor (NGF) and its receptors TrkA and p75 are well characterized to control survival, differentiation and function of ...
Mueller, Markus
core  

α7nAChR agonist GTS‐21 ameliorates sepsis‐induced acute kidney injury via MEF2/PGC‐1α/HO‐1 axis in mice

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
This diagram illustrates opposing pathways regulating AKI (acute kidney injury). The left pathway shows LPS/TLR4 triggering mitochondrial damage (low MMP, Cyt C release, ROS) leading to apoptosis. The right pathway shows α7nAChR agonists activating MEF2 to upregulate PGC‐1α/HO‐1, promoting mitochondrial biogenesis and inhibiting injury, highlighting ...
Yu‐Jia Tang, Hui‐Ying Liu, Na‐Qi Li, Xin Zhang, Yi‐Lu Lin, Yan Zhang, Yao Li, Jia‐Le Deng, Pei‐Lin Yang, Qing‐Min Meng, Yi‐Jin Tang, Zi‐Yue Zhang, Si‐Han Guan, Kai Kang, Hong‐Liang Wang, Yang Gao   +15 more
wiley   +1 more source