Results 11 to 20 of about 853 (162)

Return to Spontaneous Circulation in a Patient With Cholinergic Syndrome at the Emergency Department of Buea Regional Hospital, Cameroon. [PDF]

Clin Case Rep
ABSTRACT With the increasing misuse of herbal treatment and pesticides, cases of cholinergic syndrome following herbal treatment or organophosphate poisoning have become increasingly common in our milieu. However, when advanced, mortality is high. We report the successful management of a case involving a 54‐year‐old African female with a known history ...
Nteungue BBK, Nyuydzefon B, Kouomogne BAN, Siysi VV.   +3 more
europepmc   +2 more sources

Cholinesterase Reactivation: In Vitro Studies [PDF]

Anaesthesia and Intensive Care, 1975
In vitro studies confirm the clinical impression that P–2–AM does not reverse the cholinesterase inhibition caused by organophosphorus insecticides.
A, Ganendran, S, Balabaskaran
openaire   +2 more sources

Light-Activated Pharmacological Tools for Exploring the Cholinergic System. [PDF]

Med Res Rev
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Colleoni A, Galli G, Dallanoce C, De Amici M, Gorostiza P, Matera C.   +5 more
europepmc   +2 more sources

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

Biomolecules, 2020
(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholinesterase
André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Aurélie Nervo, José Dias, Catherine Rousseau, Charlotte Courageux, Xavier Brazzolotto, Pascal Villa, Adeline Obrecht, Jean-François Goossens, Christophe Landry, Johan Hachani, Fabien Gosselet, Marie-Pierre Dehouck, Jagadeesh Yerri, Maria Kliachyna, Rachid Baati, Florian Nachon   +18 more
doaj   +1 more source

Novel Bisquaternary Oximes—Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

Molecules, 2009
Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and ...
Daniel Jun, Jana Zdarova Karasova, Miroslav Pohanka, Martina Hrabinova, Kamil Musilek, Martin Paar, Vladimir Cirkva, Jiri Palecek, Kamil Kuca, Lucie Musilova   +9 more
doaj   +1 more source

Combined Pre- and Posttreatment of Paraoxon Exposure

Molecules, 2020
Aims: Organophosphates (OPCs), useful agents as pesticides, also represent a serious health hazard. Standard therapy with atropine and established oxime-type enzyme reactivators is unsatisfactory.
Dietrich E Lorke, Syed M Nurulain, Mohamed Y Hasan, Kamil Kuča, Georg A Petroianu   +4 more
doaj   +1 more source

An Efficient Synthesis of Pyridoxal Oxime Derivatives under Microwave Irradiation [PDF]

, 2014
Quaternary salts of pyridoxal oxime have been synthesized by the quaternization of pyridoxal oxime with substituted phenacyl bromides using microwave heating.
Bušić, Valentina, Cetina, Mario, Gašo-Sokač, Dajana, Jukić, Marijana   +3 more
core   +4 more sources

Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE ...
David Malinak, Rafael Dolezal, Vendula Hepnarova, Miroslava Hozova, Rudolf Andrys, Petr Bzonek, Veronika Racakova, Jan Korabecny, Lukas Gorecki, Eva Mezeiova, Miroslav Psotka, Daniel Jun, Kamil Kuca, Kamil Musilek   +13 more
doaj   +1 more source

Organophosphate Poisoning Simulation Case

MedEdPORTAL, 2010
This simulation case is intended for medical students and residents in emergency medicine and involves a patient that was exposed to organophosphates while working on a farm.
Jessica Brooks, Amy Zosel, Britney Anderson   +2 more
doaj   +1 more source

An acetylcholinesterase biosensor for determination of low concentrations of Paraoxon and Dichlorvos [PDF]

, 2011
The characterization of an economic and ease-to-use carbon paste acetylcholinesterase (AChE) based biosensor to determine the concentration of pesticides Paraoxon and Dichlorvos is discussed.
Arduini, F, Bencivenga, U, Di Tuoro, D, Lepore, M, Mita, D G, Moscone, D, Portaccio, M, Vitiello, A   +7 more
core   +1 more source