Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme [PDF]
, 2010 Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP ...
Andrew C. Hemmert +15 more
core +6 more sources
Oxime Reactivation of Diethylphosphoryl Human Serum Cholinesterase
Journal of Biological Chemistry, 1967 Abstract Reactivation of diethyl p-nitrophenyl phosphate inhibited human serum cholinesterase by pyridine-2-aldoxime methiodide and isonitrosoacetophenone has been investigated as a function of reactivator concentration, pH, and temperature in boric acid-borax buffer and in salt solution.
E I, Wang, P E, Braid
openaire +2 more sources
Kvalitativna procjena eliminacije TCP-a i TAMORF-a iz organizma štakora metodom GC-MS [PDF]
, 2010 Nerve agents are highly toxic organophosphorus (OP) compounds. They inhibit acetylcholinesterase (AChE), an enzyme that hydrolyses acetycholine (ACh) in the nervous system.
A. Lucić Vrdoljak +20 more
core +2 more sources
Examination of effectiveness of chemical scavengers as therapeutics in organophosphate poisoning [PDF]
, 2017 Cholinergic crisis triggered by inhibition of cholinesterases via organophosphorus nerve agents (OP) and pesticides is treated with atropine and a reactivator of inhibited cholinesterase, called oxime.
Bierwisch, Anne
core +2 more sources
Cyclosarin-An Organophosphate Nerve Agent [PDF]
, 2005 Organophosphorus compounds ascribed to as nerve agents (sarin, soman, tabun, cyclosarin) are highly toxic, and are considered to be the most dangerous chemical compounds.
Krejcova, G., Kuca, K., Sevelova, L.
core +2 more sources
Reactivation of Human Acetylcholinesterase and Butyrylcholinesterase Inhibited by Leptophos-Oxon with Different Oxime Reactivators in Vitro [PDF]
, 2010 We have evaluated in vitro the potency of 23 oximes to reactivate human erythrocyte acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE) inhibited by racemic leptophos-oxon (O-[4-bromo-2,5-dichlorophenyl]-O-methyl phenyl-phosphonate), a ...
Bajgar +20 more
core +3 more sources
Journal of Nepal Medical Association, 2008 Acute poisoning by organophosphorus (OP) compounds is a major global clinical problem, with thousands of deaths occurring every year. Most of these pesticide poisoning and subsequent deaths occur in developing countries following a deliberate self ...
Buddhi Prasad Paudyal
doaj +1 more source
In vitro evaluation of neutral oximes as reactivators of parathion-inhibited electric eel acetylcholinesterase [PDF]
, 2017 Organophosphorus (OP) compounds are irreversible inhibitors of acetylcholinesterase (AChE) commonly used as pesticides and, unfortunately, as nerve agents in terrorist attacks.
Aguiar, Alcino P. +5 more
core +2 more sources
Obidoxime Reactivation of Organophosphate-Inhibited Cholinesterase Activity in Pigs [PDF]
Acta Veterinaria Scandinavica, 1984 The ability of obidoxime to reactivate organophosphate-inhibited cholinesterases was studied in pigs treated with either trichlorfon, dichlorvos or coumaphos. In 6 pigs Cholinesterase activity was measured in the blood samples both before and after in vitro reactivation with obidoxime.
N, Gyrd-Hansen, I, Kraul
openaire +2 more sources
Computational Design, Molecular Docking Study and Toxicity Prediction of Some Novel Pralidoxime Derivatives as reactivators of acetyl cholinesterase enzyme [PDF]
Journal of Advanced Biomedical Sciences, 2019 Background & Objective: oximes as Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate compounds (OPCs) intoxication.
abozar roeintan
doaj