Results 41 to 50 of about 853 (162)

Evaluation of Cholinesterase Activities During in Vivo Intoxication Using an Electrochemical Sensor Strip – Correlation With Intoxication Symptoms [PDF]

, 2009
Cholinesterase activity in blood of laboratory rats was monitored. Rats were intoxicated with paraoxon at dosis of 0 – 65 – 125 – 170 – 250 – 500 nmol. The 250 nmol dose was found to be the LD50.
Adam, Bajgar, Bajgar, Balali-Mood, Baydin, Bernik, Borovikova, Brimjon, Chevion, Curtil, Eddieston, El-Naggar, Ellman, Fang, Jan Misík, Jana Zdarova-Karasova, Kamil Kuca, Krizkova, Krizkova, Ladislav Novotný, Levy-Khademi, Martina Hrabinova, Masson, Millard, Miroslav Pohanka, Nezhinskaia, Okuno, Pohanka, Pohanka, Pohanka, Pohanka, Pohanka, Pohanka, Pohanka, Pohanka, Pollak, Psotova, Saleh, Sinko, Soreq, Supalkova   +40 more
core   +4 more sources

Intermediate Syndrome After Organophosphate Poisoning: Clinical Course and a Case of Delayed Neuromuscular Dysfunction

Case Reports in Critical Care, Volume 2026, Issue 1, 2026.
Intermediate syndrome (IMS) is a delayed neuromuscular complication of organophosphate poisoning, typically occurring 24–96 h postexposure and often leading to respiratory failure. The author reports a 39‐year‐old male who ingested 40% chlorpyrifos and developed IMS on Day 4 post‐ingestion, presenting with proximal muscle weakness, neck flexor ...
Gudisa Bereda, Lipi Buch
wiley   +1 more source

Effect of extract of Varthemia persica DC on whole blood acetylcholinesterase activity in rats [PDF]

, 2016
Varthemia persica DC. is an aromatic plant, from the Asteraceae family, wildly growing in the central provinces of Iran. Sesquiterpene lactones that are found in Varthemia species have protective effect against organophosphates toxicity. This study aimed
Asadi-Samani, Majid., Mohammadi-Farsani, Karim., Rouhi-Boroujeni, Hojjat., Siahpoosh, Amir.   +3 more
core  

Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
The limited clinical efficacy of anti‐Aβ antibodies has challenged the Aβ hypothesis, compelling the integration of key mechanisms—including neuroinflammation, mitochondrial dysfunction, oxidative stress, and post‐translational modifications of Aβ—into a revised model of Alzheimer's disease.
Shamseddin Ahmadi, Shiler Khaledi, Kimia Ahmadi, Kambiz Hassanzadeh   +3 more
wiley   +1 more source

A systems immunology analysis of Alzheimer's disease reveals an age‐ and environmental exposure‐independent disturbance in B cell maturation

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Alzheimer's disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinical investigation suggests a neuroimmunological component to disease, with links to the peripheral immune system.
Stephanie Humblet‐Baron, Yang Feng, Rafael Veiga, Julika Neumann, Teresa Prezzemolo, Emanuela Pasciuto, Rik Vandenberghe, Lidia Yshii, Adrian Liston   +8 more
wiley   +1 more source

Effects of Oxime K203 and Oxidative Stress in Plasma of Tabun Poisoned Rats [PDF]

, 2012
The highly toxic nature of tabun has been known for many years, but there are still serious limitations to antidotal therapy. In this study, we used rats as an experimental model to evaluate the efficiency of bispyridinium para-oxime K203 as therapy ...
Ana Lucić Vrdoljak, Božica Radić, Kamil Kuča, Kamil Musilek, Suzana Berend   +4 more
core   +2 more sources

Cardiorespiratory Response to Exercise in Parkinson's Disease: Associations with Autonomic Dysfunction and Physical Activity

Movement Disorders Clinical Practice, Volume 12, Issue 11, Page 1882-1890, November 2025.
Abstract Background Both autonomic dysfunction and low levels of physical activity could contribute to reduced cardiorespiratory fitness in people with Parkinson's disease (PD). However, the interrelationship between these concepts is not well understood.
Kars I. Veldkamp, Sabine Schootemeijer, Hilde Joosten, Bastiaan R. Bloem, Luc J.W. Evers, Nienke M. de Vries   +5 more
wiley   +1 more source

Odnos strukture i aktivnosti u reaktivaciji tabunom fosforilirane ljudske acetilkolinesteraze bispiridinijevim para-aldoksimima [PDF]

, 2007
We investigated interactions of bispyridinium para-aldoximes N,N’-(propano)bis(4-hydroxyiminomethyl) pyridinium bromide (TMB-4), N,N’-(ethano)bis(4-hydroxyiminomethyl)pyridinium methanosulphonate (DMB-4), and N,N’-(methano)bis(4-hydroxyiminomethyl ...
A Bosak, A Gray, A Lucić Vrdoljak, Anita Bosak, E Heilbronn, E Reiner, F Ekström, F Worek, G Ellman, G Šinko, G Šinko, Goran Šinko, K Kuča, L Francisković, M Stojiljković, M Čalić, M Škrinjarić-Špoljar, M Škrinjarić-Špoljar, Maja Čalić, P Eyer, R Odžak, V Simeon, V Simeon-Rudolf, Y Ashani, Y-P Pang, Z Kovarik, Z Kovarik, Z Kovarik, Zrinka Kovarik   +28 more
core   +2 more sources

Organophosphate Poisoning: Insights From a Case Report of Acute Cholinergic Syndrome

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Organophosphate (OP) pesticides are widely used in agriculture and can cause acute cholinergic toxicity by inhibiting the enzyme acetylcholinesterase, leading to an accumulation of acetylcholine. A 45‐year‐old male plumber was admitted to the emergency department 4 h after ingesting an unknown quantity of a 50% emulsifiable concentration of ...
Gudisa Bereda
wiley   +1 more source

Synthesis and disinfection effect of the pyridine-4-aldoxime based salts [PDF]

, 2015
PubMed ID: 25719739A set of new quaternary ammonium compounds based on pyridine-4-aldoxime was synthesized, characterized with analytical data (NMR, EA, HPLC, MS) and tested for in vitro antimicrobial activity (antibacterial, antifungal) and cytotoxicity.
Doležal, Martin, Doležal, Rafael, Kuča, Kamil, Maliňák, David, Marek, Jan, Pasdiorová, Markéta, Soukup, Ondřej   +6 more
core   +3 more sources