Results 51 to 60 of about 853 (162)

Gene and RNA Editing: Revolutionary Approaches to Treating Diseases

MedComm, Volume 6, Issue 10, October 2025.
The image illustrates gene editing technologies: DNA editing using CRISPR–Cas9 and RNA editing via Cas13d, with their clinical applications and ethical risks. DNA editing allows precise gene modifications for conditions like amyotrophic lateral sclerosis [ALS] and Huntington's disease, while RNA editing supports multiplexed modifications.
Jia‐Mei Li, Jie Huang, Yan Liao, Ting Hu, Chang‐Li Wang, Wang‐Zheqi Zhang, Chen‐Wei Huang   +6 more
wiley   +1 more source

Illuminating the Unseen: Dynamic Butyrylcholinesterase Detection Driving Precision Medicine and Environmental Toxicology

SmartMat, Volume 6, Issue 5, October 2025.
Butyrylcholinesterase (BChE), a key member of the cholinesterase family, plays an indispensable role in neural signal regulation, Alzheimer's disease therapeutic development, metabolic homeostasis, and clinical toxicology diagnostics. This study provides a comprehensive review of existing analytical methodologies for BChE detection, along with their ...
Min Liu, Shuaige Bai, Shuai Huang, Ting Luo, Yiyang Zhou, Meihui Liu, Xueping Feng, Wenbin Zeng   +7 more
wiley   +1 more source

Holinergični sindrom: prikaz primera zastrupitve z organofosfati in karbamati [PDF]

, 2020
Cholinergic syndrome is a common topic at western medical universities yet rarely observed in clinical practice. The treatment involves muscarinic antagonists, acetylcholinesterase reactivation, seizure control, and supportive measures.
Barbara Kit, Damjan Grenc, Matej Strnad, Tadej Petreski   +3 more
core   +2 more sources

Midostaurin in daily clinical practice of patients with advanced systemic mastocytosis

British Journal of Haematology, Volume 207, Issue 4, Page 1388-1396, October 2025.
Durable responses based on modified Valent, IWG‐MRT‐ECNM and PPR criteria were predominantly dose‐independent, making dose adjustments due to better tolerability more practicable in daily routine. Gradual tapering of midostaurin, prophylactic treatment with antihistamines and corticosteroids and timely initiation of subsequent therapy can prevent a ...
Johannes Lübke, Nicole Naumann, Timo Brand, Laurenz Steiner, Roland Repp, Georgia Metzgeroth, Alice Fabarius, Wolf‐Karsten Hofmann, Deepti H. Radia, Andreas Reiter, Juliana Schwaab   +10 more
wiley   +1 more source

Tics and Parkinson's Disease: Clinical and Pathophysiological Insights from a Rare Syndromic Association

Movement Disorders Clinical Practice, Volume 12, Issue 8, Page 1173-1180, August 2025.
Abstract Background The coexistence of tics with Parkinson's disease (PD) is rare, as they often emerge at different ages, follow different trajectories and involve contrasting pathophysiological mechanisms related to dopamine availability and function in the brain. Cases We present 10 individuals with primary tic disorders who later developed PD.
Tarig Abkur, Alexandra Boogers, Talyta Grippe, David A. Isaacs, Irene A. Malaty, Renato P. Munhoz, Kailash P. Bhatia, Lauren A. Hart, Alfonso Fasano, Suneil Kalia, Anthony E. Lang, Christos Ganos   +11 more
wiley   +1 more source

Acute and persistent changes in neural oscillatory activity predict development of epilepsy following acute organophosphate intoxication in adult rats

Epilepsia, Volume 66, Issue 4, Page 1329-1342, April 2025.
Abstract Objective Acute organophosphate (OP) intoxication affects a significant number of individuals worldwide. Those who survive OP‐induced cholinergic crisis, which includes status epilepticus, often develop neurological morbidities. Here, we provide a rigorous characterization of the acute and delayed electrophysiological responses to OP ...
Jeremy A. MacMahon, Peter M. Andrew, Ali Izadi, Donald A. Bruun, Naomi H. Saito, Daniel J. Tancredi, Amy Brooks‐Kayal, Pamela J. Lein, Gene G. Gurkoff   +8 more
wiley   +1 more source

Allopregnanolone as an Adjunct Therapy to Midazolam is More Effective Than Midazolam Alone in Suppressing Soman‐Induced Status Epilepticus in Male Rats

CNS Neuroscience &Therapeutics, Volume 31, Issue 3, March 2025.
Acute poisoning with the organophosphate, soman, triggers status epilepticus that rapidly becomes refractory to standard of care treatment with midazolam (MDZ). Combined treatment with MDZ and allopregnanolone (ALLO) significantly suppresses seizure activity, which is associated with attenuated neurodegeneration and neuroinflammation.
Peter M. Andrew, Jeremy A. MacMahon, Xiuzhen Liu, Naomi H. Saito, Kyle E. Berger, Julia E. Morgan, Ashish Dhir, Danielle J. Harvey, Hilary S. McCarren, Michael A. Rogawski, Pamela J. Lein   +10 more
wiley   +1 more source

Preparation of Oxime HI-6 (Dichloride and Dimethanesulphonate)ŒAntidote against Nerve Agents [PDF]

, 2008
Because of the threat of misuse of nerve agents as terroristic weapons by the terrorists, animmediate need is felt for the preparation of antidotes on large-scale basis.
Dolezal, Bohumil, Hanusova, Petra, Hrabinova, Martina, Jun, Daniel, Kuca, Kamil, Stodulka, Petr   +5 more
core   +2 more sources

Inhibition of proline‐rich tyrosine kinase 2 restores cardioprotection by remote ischaemic preconditioning in type 2 diabetes

British Journal of Pharmacology, Volume 181, Issue 21, Page 4174-4194, November 2024.
Abstract Background and Purpose Remote ischaemic preconditioning (rIPC) for cardioprotection is severely impaired in diabetes, and therapeutic options to restore it are lacking. The vascular endothelium plays a key role in rIPC. Given that the activity of endothelial nitric oxide synthase (eNOS) is inhibited by proline‐rich tyrosine kinase 2 (Pyk2), we
Ralf Erkens, Dragos Andrei Duse, Amanda Brum, Alexandra Chadt, Stefanie Becher, Mauro Siragusa, Christine Quast, Johanna Müssig, Michael Roden, Miriam Cortese‐Krott, Borja Ibáñez, Eckhard Lammert, Ingrid Fleming, Christian Jung, Hadi Al‐Hasani, Gerd Heusch, Malte Kelm   +16 more
wiley   +1 more source

Anal Chem [PDF]

Hydrolysis of G- and V-series organophosphorus nerve agents (OPNAs) containing a phosphorus-methyl bond yields a methylphosphonic acid (MeP) product when adducted to human butyrylcholinesterase (BChE).

core