Results 41 to 50 of about 170,603 (392)

Development of Anti-OSCAR Antibodies for the Treatment of Osteoarthritis

Biomedicines, 2023
Osteoarthritis (OA) is the most common joint disease that causes local inflammation and pain, significantly reducing the quality of life and normal social activities of patients.
Gyeong Min Kim, Doo Ri Park, Thi Thu Ha Nguyen, Jiseon Kim, Jihee Kim, Myung-Ho Sohn, Won-Kyu Lee, Soo Young Lee, Hyunbo Shim   +8 more
doaj   +1 more source

Enhanced Tissue Integration During Cartilage RepairIn VitroCan Be Achieved by Inhibiting Chondrocyte Death at the Wound Edge [PDF]

, 2009
Objective: Experimental wounding of articular cartilage results in cell death at the lesion edge. The objective of this study was to investigate whether inhibition of this cell death results in enhanced integrative cartilage repair.
Archer, Charles W., Burdon, Drew, Duance, Victor C., Gilbert, Sophie J., Gonzalez, Lee G., Khan, Ilyas M., Singhrao, Simarjit Kaur, Thomson, Brian M.   +7 more
core   +1 more source

A Preliminary Study of Human Amniotic Membrane as a Potential Chondrocyte Carrier [PDF]

Malaysian Orthopaedic Journal, 2009
PURPOSE: To investigate the feasibility of using processed human amniotic membrane (HAM) to support the attachment and proliferation of chondrocytes in vitro which in turn can be utilised as a cell delivery vehicle in tissue engineering applications.
L Boo, S Sofiah, L Selvaratnam, CC Tai, Pingguan-Murphy B, T Kamarul   +5 more
doaj  

Ochronotic Chondropathy: A Case Report

Biomedicines, 2023
Endogenous ochronosis, also known as alkaptonuria, is a rare disease known for its bluish-black discoloration of the skin, sclerae, and pinnae, as well as urine that turns black upon standing.
Jake Littman, John Pietro, Jon Olansen, Chanika Phornphutkul, Roy K. Aaron   +4 more
doaj   +1 more source

Treatment of failed articular cartilage reconstructive procedures of the knee: A systematic review [PDF]

, 2018
Background: Symptomatic articular cartilage lesions of the knee are common and are being treated surgically with increasing frequency. While many studies have reported outcomes following a variety of cartilage restoration procedures, few have ...
Lamplot, Joseph D, Matava, Matthew J, Schafer, Kevin A   +2 more
core   +2 more sources

Preconditioning of mesenchymal stromal cells with low-intensity ultrasound: influence on chondrogenesis and directed SOX9 signaling pathways [PDF]

, 2020
Background: Continuous low-intensity ultrasound (cLIUS) facilitates the chondrogenic differentiation of human mesenchymal stromal cells (MSCs) in the absence of exogenously added transforming growth factor-beta (TGFβ) by upregulating the expression of ...
A Argentaro, A Augello, A Katsumi, A Woods, A Woods, AD Miller, AH Huang, B Yang, BH Choi, C Huang, C Matta, CA Simmons, CB Little, CJ O’Conor, CY Huang, D Schumann, DR Haudenschild, EM Darling, F Dell'Accio, G Coricor, H Sim, H-C Hsu, HJ Kwon, HJ Lee, HJ Lee, J Li, J Puetzer, JC Sng, JD Kisiday, JH Cui, JH Cui, JW Choi, K Ebisawa, K Pelttari, L Bian, Li Ling, LJ Ng, M Shakibaei, M Tsuda, MA Corrigan, MB Mueller, N Fahy, N Thelin, NP Whitney, P Müller, R Ogawa, RL Mauck, RM Delaine-Smith, RS Tigli, S Murakami, S Noriega, S Noriega, S Yamaguchi, SD Cook, SD Cook, T Furumatsu, T Guo, T Ito, T Juhasz, T Nishida, T Sanjukta Guha, TM Louw, V Lefebvre, V Lefebvre, W Huang, W Huang, Z Li, ZJ Zhang   +67 more
core   +2 more sources

Novel Heredity Basis of the Four-Horn Phenotype in Sheep Using Genome-Wide Sequence Data

Animals, 2023
Horns are an important breeding trait for sheep. However, no widely recognized viewpoint on the regulatory genes and mechanisms of horns is available, and the genetic basis of the four-horn phenotype (FHP) is unclear.
Haoyuan Zhang, Pu Yang, Chengli Liu, Yuehui Ma, Yanguo Han, Yan Zeng, Yongfu Huang, Yongju Zhao, Zhongquan Zhao, Xiaohong He, Guangxin E   +10 more
doaj   +1 more source

Metaplasia of Chondrocytes into Osteoblasts

Folia Biologica, 2006
Hypertrophic chondrocytes, commonly considered as terminal cells responsible for apoptotic elimination in endochondral osteogenesis, have the potential to switch their metabolic role and enter osteoblastic differentiation, based on histochemical, immunohistochemical, biochemical and cytological analysis.
Krzysztof H Włodarski, Aniela Brodzikowska, Paweł Włodarski   +2 more
openaire   +2 more sources

In Vivo Chondrocyte Mechanics [PDF]

Biophysical Journal, 2010
Mechanical loading of joints deforms articular cartilage cells, and that these cells provide the signals for maintaining cartilage health. Excessive loading of cartilage and cells leads to cartilage degeneration and osteoarthritis.Recently, we developed a novel in vivo testing system that allows for quantification of the mechano-biology of chondrocytes
Ruth A. Seerattan, André Leumann, Ziad Abusara, Walter Herzog   +3 more
openaire   +2 more sources

Hsa_circ_0005567 Activates Autophagy and Suppresses IL-1β-Induced Chondrocyte Apoptosis by Regulating miR-495

Frontiers in Molecular Biosciences, 2020
Excessive chondrocyte apoptosis is mostly responsible for the progression of osteoarthritis (OA). It has been shown that circular RNAs (circRNAs) are differentially expressed in OA cartilage and participate in various pathological processes during OA ...
Jinling Zhang, Fangyue Cheng, Genxiang Rong, Zhi Tang, Binjie Gui   +4 more
doaj   +1 more source