Results 41 to 50 of about 118,065 (344)

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source

Single-cell RNA sequencing reveals different chondrocyte states in femoral cartilage between osteoarthritis and healthy individuals

Frontiers in Immunology
BackgroundCartilage injury is the main pathological manifestation of osteoarthritis (OA). Healthy chondrocyte is a prerequisite for cartilage regeneration and repair.
Zewen Sun, Zewen Sun, Mingyue Yan, Mingyue Yan, Junjie Wang, Junjie Wang, Haoyun Zhang, Xiaobin Ji, Yujing Xiao, Tianrui Wang, Tianrui Wang, Tengbo Yu, Tengbo Yu   +12 more
doaj   +1 more source

The art of building bone: emerging role of chondrocyte-to-osteoblast transdifferentiation in endochondral ossification

Bone Research, 2018
There is a worldwide epidemic of skeletal diseases causing not only a public health issue but also accounting for a sizable portion of healthcare expenditures.
Patrick Aghajanian, S. Mohan
semanticscholar   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Autologous chondrocyte implantation in the knee: systematic review and economic evaluation.

Health Technology Assessment, 2017
BACKGROUND The surfaces of the bones in the knee are covered with articular cartilage, a rubber-like substance that is very smooth, allowing frictionless movement in the joint and acting as a shock absorber.
H. Mistry, M. Connock, J. Pink, D. Shyangdan, C. Clar, P. Royle, R. Court, L. Biant, A. Metcalfe, N. Waugh   +9 more
semanticscholar   +1 more source

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

Advanced Biology, EarlyView.
Using supramolecular monomers, various hydrogel culture systems were formulated to culture protoplasts; including 2D, 2.5D, and 3D hydrogels. Depending on the culture platform, bioactive functionalization led to protoplast enlargement (2D and 2.5D) or plasmolysis (3D). This work shows the potential to modularly engineer synthetic platforms for cellular
Maritza M. Rovers, Erik J. Slootweg, Ferdinand C. O. Los, Patricia Y. W. Dankers   +3 more
wiley   +1 more source

Iron regulates chondrocyte phenotype in haemophilic cartilage through the PTEN/PI3 K/AKT/FOXO1 pathway

Hematology, 2023
Objective Our previous study demonstrated that iron overload could lead to haemophilic cartilage destruction by changing chondrocyte phenotype. This change was caused by iron’s effect on chondrocyte expression of FGF23 and SOX9, in addition to iron ...
Liujie Zheng, Yunfeng Yao, Dasheng Luo, Zhiwei Han, Xin Zhang, Nanyu Pang, Mingyang Ding, Houlong Ye, Keyan Zhu, Wenkai Yi   +9 more
doaj   +1 more source

Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 ‘Sponge’ in Human Cartilage Degradation

Scientific Reports, 2016
Circular RNAs (circRNAs) are involved in the development of various diseases, but there is little knowledge of circRNAs in osteoarthritis (OA). The aim of study was to identify circRNA expression in articular cartilage and to explore the function of ...
Qiang Liu, Xin Zhang, Xiaoqing Hu, Linghui Dai, Xin Fu, Ji-ying Zhang, Y. Ao   +6 more
semanticscholar   +1 more source

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

Advanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu, Yanbo Shan, Yingjie Xiong, Jianting Ye, Yanbin Wu, Jipeng Song, Yao Zhang, Wancheng Lin, Haoye Meng, Wenjing Xu, Jiang Peng, Qiang Lu, Lixiang Ding   +12 more
wiley   +1 more source

Characterisation of Growth Plate Dynamics in Murine Models of Osteoarthritis

Frontiers in Endocrinology, 2021
The purpose of this study was to investigate growth plate dynamics in surgical and loading murine models of osteoarthritis, to understand whether abnormalities in these dynamics are associated with osteoarthritis development. 8-week-old C57BL/6 male mice
Hasmik J. Samvelyan, Hasmik J. Samvelyan, Hasmik J. Samvelyan, Kamel Madi, Anna E. Törnqvist, Anna E. Törnqvist, Behzad Javaheri, Katherine A. Staines, Katherine A. Staines   +8 more
doaj   +1 more source