Results 41 to 50 of about 156,620 (407)

Use of autologous adipose-derived mesenchymal stem cells for creation of laryngeal cartilage [PDF]

, 2017
OBJECTIVES/HYPOTHESIS: Adipose-derived mesenchymal stem cells (ASCs) are an exciting potential cell source for tissue engineering because cells can be derived from the simple excision of autologous fat.
Brookes, Sarah, Halum, Stacey, Parker, Noah, Voytik-Harbin, Sherry, Wallace, Joseph, Zhang, Hongji, Zhang, Lujuan   +6 more
core   +1 more source

Hsa_circ_0005567 Activates Autophagy and Suppresses IL-1β-Induced Chondrocyte Apoptosis by Regulating miR-495

Frontiers in Molecular Biosciences, 2020
Excessive chondrocyte apoptosis is mostly responsible for the progression of osteoarthritis (OA). It has been shown that circular RNAs (circRNAs) are differentially expressed in OA cartilage and participate in various pathological processes during OA ...
Jinling Zhang, Fangyue Cheng, Genxiang Rong, Zhi Tang, Binjie Gui   +4 more
doaj   +1 more source

Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta [PDF]

Arthritis Research \& Therapy, 2010, 13 (1), pp.R23. \. \<10.1038/sj.onc.1204808\>, 2015
Transforming growth factor beta (TGF$\beta$) plays a central role in morphogenesis, growth, and cell differentiation. This cytokine is particularly important in cartilage where it regulates cell proliferation and extracellular matrix synthesis. While the action of TGF$\beta$ on chondrocyte metabolism has been extensively catalogued, the modulation of ...
arxiv   +1 more source

Cell-based Approaches to Joint Surface Repair : A Research Perspective [PDF]

, 2013
The authors are grateful for support to their research from Arthritis Research UK (grants 19271, 19429, 19667, 20050). None of the authors received any funding related to the writing of this manuscript, and the funding bodies did not play any role in the
A.J. Roelofs, Alegre-Aguaron, Augello, Barbero, Bentley, Bentley, Boneberg, Bos, Boxall, Brittberg, Buckwalter, C. De Bari, Centeno, Cole, Da Silva, De Bari, De Bari, De Bari, De Bari, Dell'Accio, Dell'Accio, Dominici, Dowthwaite, Eltawil, Farrell, Frank, Friedenstein, Gelber, Gilbert, Gomoll, Hangody, Hennig, Huang, Huang, J.P.J. Rocke, Jacobi, Jiang, Johnson, Jones, Kafienah, Karystinou, Khan, Kim, Knutsen, Knutsen, Koga, Koga, Koshino, Kreuz, Kuroda, Kuroda, Kurth, Lee, Magnussen, Maijenburg, Marsano, Mauck, Mendez-Ferrer, Minas, Mochizuki, Muraglia, Murata, Murphy, Nakahara, Nejadnik, Pabbruwe, Park, Pelttari, Peterson, Peterson, Pittenger, Prockop, Qiu, Quirici, Roberts, Roberts, Sacchetti, Sakaguchi, Saris, Saris, Schnabel, Scotti, Sekiya, Shirasawa, Silverman, Steadman, Studer, Takahashi, Tasso, Ter Huurne, Tormin, Van de Breevaart, Vanlauwe, Vinardell, Von der Mark, Wakitani, Wakitani, Wakitani, Wei, Williams, Yoshimura, Zhang, Zhang, Zuk   +103 more
core   +1 more source

In Vivo Chondrocyte Mechanics [PDF]

Biophysical Journal, 2010
Mechanical loading of joints deforms articular cartilage cells, and that these cells provide the signals for maintaining cartilage health. Excessive loading of cartilage and cells leads to cartilage degeneration and osteoarthritis.Recently, we developed a novel in vivo testing system that allows for quantification of the mechano-biology of chondrocytes
Ruth A. Seerattan, André Leumann, Ziad Abusara, Walter Herzog   +3 more
openaire   +2 more sources

Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]

, 2014
SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Chapple, JP, Knight, MM, Thompson, CL
core   +2 more sources

Mechanisms of chondrocyte apoptosis

Osteoarthritis and Cartilage, 1999
This study addresses the occurrence and significance of chondrocyte apoptosis in the pathogenesis of cartilage destruction. Chondrocyte apoptosis can be induced in vitro by nitric oxide donors, but not by pro-inflammatory cytokines, such as IL-1 or TNF.
Klaus Kühn, Martin Lotz, Sanshiro Hashimoto   +2 more
openaire   +3 more sources

Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures [PDF]

, 2013
The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In recent years cartilage tissue engineering has shown great promise.
Blitterswijk, C.A. van, Georgi, N., Karperien, H.B.J., Leijten, J.C.H., Wu, L.   +4 more
core   +3 more sources

Increased Expression of Sox9 during Balance of BMSCs/Chondrocyte Bricks in Platelet-Rich Plasma Promotes Construction of a Stable 3-D Chondrogenesis Microenvironment for BMSCs

Stem Cells International, 2020
Sox9 is an intrinsic transcription factor related to the determination and maintenance of chondrogenic lineage of bone marrow mesenchymal stem cells (BMSCs).
Ruikai Ba, Liang Kong, Guofeng Wu, Shiyu Liu, Yan Dong, Bei Li, Yimin Zhao   +6 more
doaj   +1 more source

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.

Genes & Development, 2002
To examine whether the transcription factor Sox9 has an essential role during the sequential steps of chondrocyte differentiation, we have used the Cre/loxP recombination system to generate mouse embryos in which either Sox9 is missing from ...
H. Akiyama, M. Chaboissier, James F. Martin, A. Schedl, B. De Crombrugghe   +4 more
semanticscholar   +1 more source