Results 51 to 60 of about 118,065 (344)

Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis

Aging Cell, 2018
Cellular senescence drives a functional decline of numerous tissues with aging by limiting regenerative proliferation and/or by producing pro‐inflammatory molecules known as the senescence‐associated secretory phenotype (SASP).
B. Diekman, G. Sessions, J. Collins, Anne K. Knecht, S. Strum, N. Mitin, C. Carlson, R. Loeser, N. Sharpless   +8 more
semanticscholar   +1 more source

Mechanoelectrical transduction in chondrocytes

Clinical and Experimental Pharmacology and Physiology, 2018
SummaryCartilage tissue lines the joints of mammals, helping to lubricate joint movement and distribute mechanical loads. This tissue is comprised of isolated cells known as chondrocytes which are embedded in an extracellular matrix. Chondrocytes produce and maintain the cartilage by sensing and responding to changing mechanical loads. Mechanosensitive
Servin-Vences, MR, Richardson, J, Lewin, GR, Poole, K   +3 more
openaire   +4 more sources

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation

Frontiers in Pharmacology, 2021
Osteoarthritis (OA) is the most prevalent joint disease worldwide, making it a major cause of pain and disability. Identified as a chronic and progressive disease, effective treatment at the early stages of OA has become critical to its management ...
Chenyang Zhuang, Zixiang Wang, Weisin Chen, Hanquan Wang, Bo Tian, Hong Lin, Hong Lin   +6 more
doaj   +1 more source

A Visible Light‐Responsive Hydrogel to Study the Effect of Dynamic Tissue Stiffness on Cellular Mechanosensing

Advanced Functional Materials, EarlyView.
A visible light‐responsive polyacrylamide‐azobenzene hydrogel enables safe, reversible stiffness control for studying cell mechanobiology without harmful UV exposure. This approach reveals stem cells respond rapidly to mechanical changes, showing altered shape and protein distribution within one hour.
Aafreen Ansari, Sanchyan Bhowmik, Kaiwen Zhang, Chayla L. Reeves, Danielle Vahala, Yu Suk Choi, Amy Gelmi, Alexander N. Combes, Rocky S. Tuan, Vinh X. Truong, John S. Forsythe, Jessica E. Frith   +11 more
wiley   +1 more source

Hyaluronan production and chondrogenic properties of primary human chondrocyte on gelatin based hematostatic spongostan scaffold

Journal of Orthopaedic Surgery and Research, 2012
Background Autologous chondrocyte transplantation is a promising technique for treatment of cartilage defects. Three dimensional chondrocyte cultures on a scaffold are widely used to retain the chondrogenic phenotype.
Klangjorhor Jeerawan, Nimkingratana Puwapong, Settakorn Jongkolnee, Pruksakorn Dumnoensun, Leerapun Taninnit, Arpornchayanon Olarn, Rojanasthien Sattaya, Kongtawelert Prachya, Pothacharoen Peraphan   +8 more
doaj   +1 more source

A high-resolution route map reveals distinct stages of chondrocyte dedifferentiation for cartilage regeneration

Bone Research, 2022
Articular cartilage damage is a universal health problem. Despite recent progress, chondrocyte dedifferentiation has severely compromised the clinical outcomes of cell-based cartilage regeneration.
Yishan Chen, Yeke Yu, Ya Wen, Juan Chen, Junxin Lin, Zixuan Sheng, Wenyan Zhou, Heng Sun, Chengrui An, Jiansong Chen, Weiliang Wu, Chong Teng, Wei Wei, Hongwei Ouyang   +13 more
doaj   +1 more source

The role of TGF-β2 in cartilage development and diseases

Bone & Joint Research, 2021
Transforming growth factor-beta2 (TGF-β2) is recognized as a versatile cytokine that plays a vital role in regulation of joint development, homeostasis, and diseases, but its role as a biological mechanism is understood far less than that of its ...
Mengmeng Duan, Qingxuan Wang, Yang Liu, Jing Xie   +3 more
doaj   +1 more source

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Single-cell RNA-seq analysis reveals the Wnt/Ca2+ signaling pathway with inflammation, apoptosis in nucleus pulposus degeneration

BMC Musculoskeletal Disorders
Background Increasing studies have shown degeneration of nucleus pulposus cells (NPCs) as an critical part of the progression of intervertebral disc degeneration (IVDD).
Peigeng Wang, Zhencong Li, Dongping Ye
doaj   +1 more source