Results 51 to 60 of about 156,620 (407)

The chondro-osseous continuum: is it possible to unlock the potential assigned within? [PDF]

, 2018
Endochondral ossification (EO), by which long bones of the axial skeleton form, is a tightly regulated process involving chondrocyte maturation with successive stages of proliferation, maturation, and hypertrophy, accompanied by cartilage matrix ...
Adams, Aizawa, Akintoye, Amling, Bahney, Ballock, Behonick, Boegård, Brachet, Cancedda, Candeliere, Carames, Clarkin, Colnot, Colnot, Day, Dodds, Emons, Enishi, Erenpreisa, Farnum, Farnum, Felson, Galotto, Gebhard, Gerstenfeld, Gibson, Gibson, Hall, Holmbeck, Hu, Hughes, Hunter, Javaheri, Jing, Johnell, Karaplis, Kawaguchi, Kuttapitiya, Lavigne, Lian, Lieu, Mackie, Maeda, Maes, Maes, Marigo, Moskalewski, Murphy, Ono, Ortega, Park, Pottenger, Poulet, Provot, Rawlinson, Riminucci, Roach, Roach, Roach, Shah, Shapiro, Silbermann, Song, Stafford, Stickens, Thesingh, Tsang, Van der Stricht, Vortkamp, Vu, Wade-Gueye, Wang, Woolf, Yang, Yoshioka, Zelzer, Zenmyo, Zhou, Zhou   +79 more
core   +3 more sources

Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1−SMAD1 interaction

Bone Research, 2019
Hypertrophic differentiation is not only the terminal process of endochondral ossification in the growth plate but is also an important pathological change in osteoarthritic cartilage.
Chengjie Lian, Xudong Wang, X. Qiu, Zizhao Wu, Bo Gao, Lei Liu, Guo-yan Liang, Hang Zhou, Xiaoming Yang, Yan Peng, Anjing Liang, Caixia Xu, Dongsheng Huang, Peiqiang Su   +13 more
semanticscholar   +1 more source

Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA [PDF]

, 2015
Objective: To use deep sequencing to identify novel microRNAs in human osteoarthritic cartilage which have a functional role in chondrocyte phenotype or function.
Aigner, Andresen Eguiluz, Barter, Benz, Bernardo, Casagrande, Chong, Culley, D.A. Young, Diaz-Prado, Dudek, G. Wheeler, Gao, Git, Goldring, Goldring, Gomez, Grgurevic, Guo, H. Pais, Himly, I.M. Clark, Ijiri, Iliopoulos, Jin, Jones, Kato, Kozomara, L.T.T. Le, Le, Liu, Loeser, Lories, M.J. Barter, Martinez-Sanchez, Miyaki, Moxon, N. Crowe, Nakamura, Nakamura, Peffers, Prufer, S.T. Donell, Scanzello, Scott, Scott, Singh, Sorefan, Steck, Sun, Swingler, T. Dalmay, T.E. Swingler, Tardif, Team, Troeberg, Winter, Xiao, Yang, Zhai   +59 more
core   +1 more source

Iron regulates chondrocyte phenotype in haemophilic cartilage through the PTEN/PI3 K/AKT/FOXO1 pathway

Hematology, 2023
Objective Our previous study demonstrated that iron overload could lead to haemophilic cartilage destruction by changing chondrocyte phenotype. This change was caused by iron’s effect on chondrocyte expression of FGF23 and SOX9, in addition to iron ...
Liujie Zheng, Yunfeng Yao, Dasheng Luo, Zhiwei Han, Xin Zhang, Nanyu Pang, Mingyang Ding, Houlong Ye, Keyan Zhu, Wenkai Yi   +9 more
doaj   +1 more source

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis

International Journal of Molecular Sciences, 2015
Apoptosis is a highly-regulated, active process of cell death involved in development, homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as cancer, developmental anomalies and degenerative diseases. Osteoarthritis (OA),
H. Hwang, H. Kim
semanticscholar   +1 more source

An injectable, self-healing and MMP-inhibiting hyaluronic acid gel via iron coordination [PDF]

, 2021
Regulating the activity of matrix metalloproteinases (MMPs) is a potential strategy for osteoarthritis (OA) therapy, although delivering this effect in a spatially and temporally localised fashion remains a challenge. Here, we report an injectable and self-healing hydrogel enabling factor-free MMP regulation and biomechanical competence in situ.
arxiv   +1 more source

The Incidence and Clinical Relevance of Graft Hypertrophy After Matrix-Based Autologous Chondrocyte Implantation [PDF]

, 2012
Background: Graft hypertrophy is the most common complication of periosteal autologous chondrocyte implantation (p-ACI). Purpose: The aim of this prospective study was to analyze the development, the incidence rate, and the persistence of graft ...
Annie Horng, Eckstein F, Isa Feist-Pagenstert, Matthias F. Pietschmann, Mehmet F. Gülecyüz, Peter E. Müller, Thomas R. Niethammer, Volkmar Jansson   +7 more
core   +1 more source

Autologous Chondrocyte Implantation [PDF]

JBJS Essential Surgical Techniques, 2016
Autologous chondrocyte implantation (ACI) for the treatment of articular cartilage lesions of the knee joint provides successful and durable long-term outcomes.Obtain standing radiographs and magnetic resonance imaging (MRI) scans to identify all associated abnormalities (background factors).Evaluate the knee joint systematically and harvest cartilage ...
Tom Minas, Tim Bryant, Takahiro Ogura
openaire   +3 more sources

The Role of Chondrocyte Morphology and Volume in Controlling Phenotype—Implications for Osteoarthritis, Cartilage Repair, and Cartilage Engineering

Current Rheumatology Reports, 2019
Purpose of ReviewArticular chondrocytes are exclusively responsible for the turnover of the extracellular matrix (ECM) of hyaline cartilage. However, chondrocytes are phenotypically unstable and, if they de-differentiate into hypertrophic or fibroblastic
A. Hall
semanticscholar   +1 more source

Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations

Cells, 2022
Autologous chondrocyte implantation (ACI) is a cell therapy to repair cartilage defects. In ACI a biopsy is taken from a non-load bearing area of the knee and expanded in-vitro.
Noor A. Al-Maslamani, Rachel Oldershaw, Simon Tew, Jude Curran, Pieter D’Hooghe, Kazuhiro Yamamoto, Henning F. Horn   +6 more
doaj   +1 more source