Results 61 to 70 of about 170,603 (392)

Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1−SMAD1 interaction

Bone Research, 2019
Hypertrophic differentiation is not only the terminal process of endochondral ossification in the growth plate but is also an important pathological change in osteoarthritic cartilage.
Chengjie Lian, Xudong Wang, X. Qiu, Zizhao Wu, Bo Gao, Lei Liu, Guo-yan Liang, Hang Zhou, Xiaoming Yang, Yan Peng, Anjing Liang, Caixia Xu, Dongsheng Huang, Peiqiang Su   +13 more
semanticscholar   +1 more source

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]

, 2013
© 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P, Bader, DL, Chowdhury, TT, Hobbs, AJ, Moyes, AJ, Peake, N, Ramachandran, M, Salter, DM, Su, N   +8 more
core   +2 more sources

Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation

Frontiers in Pharmacology, 2021
Osteoarthritis (OA) is the most prevalent joint disease worldwide, making it a major cause of pain and disability. Identified as a chronic and progressive disease, effective treatment at the early stages of OA has become critical to its management ...
Chenyang Zhuang, Zixiang Wang, Weisin Chen, Hanquan Wang, Bo Tian, Hong Lin, Hong Lin   +6 more
doaj   +1 more source

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.

Genes & Development, 2002
To examine whether the transcription factor Sox9 has an essential role during the sequential steps of chondrocyte differentiation, we have used the Cre/loxP recombination system to generate mouse embryos in which either Sox9 is missing from ...
H. Akiyama, M. Chaboissier, James F. Martin, A. Schedl, B. De Crombrugghe   +4 more
semanticscholar   +1 more source

Immunogenicity of chondrocyte sheets: a review

Frontiers in Immunology
The chondrocyte sheet is a sheet-like cell structure obtained by separating in vitro expanded and fused autologous chondrocytes from the bottom of the culture dish by physical means.
Juncen Li, Juncen Li, Juncen Li, Huilin Sun, Huilin Sun, Huilin Sun, Jiaqi Guan, Jiaqi Guan, Jiaqi Guan, Bohui Li, Bohui Li, Bohui Li, Chen Jin, Chen Jin, Chen Jin, Shanhong Xie, Shanhong Xie, Shanhong Xie, Yu Liu, Yu Liu, Yu Liu, Yu Liu   +21 more
doaj   +1 more source

The role of TGF-β2 in cartilage development and diseases

Bone & Joint Research, 2021
Transforming growth factor-beta2 (TGF-β2) is recognized as a versatile cytokine that plays a vital role in regulation of joint development, homeostasis, and diseases, but its role as a biological mechanism is understood far less than that of its ...
Mengmeng Duan, Qingxuan Wang, Yang Liu, Jing Xie   +3 more
doaj   +1 more source

ADAM15 modulates outside-in signalling in chondrocyte–matrix interactions [PDF]

, 2008
ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions.
Burkhardt, Harald, Böhm, Beate B., Schirner, Andrea   +2 more
core   +1 more source

Hybrid bioprinting of chondrogenically induced human mesenchymal stem cell spheroids [PDF]

, 2020
To date, the treatment of articular cartilage lesions remains challenging. A promising strategy for the development of new regenerative therapies is hybrid bioprinting, combining the principles of developmental biology, biomaterial science, and 3D ...
Asadian, Mahtab, De Geyter, Nathalie, De Moor, Lise, Declercq, Heidi, Dubruel, Peter, Fernandez, Sélina, Tytgat, Liesbeth, Van Vlierberghe, Sandra, Vercruysse, Chris   +8 more
core   +2 more sources

Neutrophil Elastase Induces Chondrocyte Apoptosis and Facilitates the Occurrence of Osteoarthritis via Caspase Signaling Pathway

Frontiers in Pharmacology, 2021
Osteoarthritis (OA) is the most common and prevalent chronic joint disorders in the elderly population across the globe, resulting in severe disability and impairment of quality of life.
Ganyu Wang, Weiqiang Jing, Yuxuan Bi, Yue Li, Liang Ma, Hui Yang, Yuankai Zhang   +6 more
doaj   +1 more source

The Role of Chondrocyte Morphology and Volume in Controlling Phenotype—Implications for Osteoarthritis, Cartilage Repair, and Cartilage Engineering

Current Rheumatology Reports, 2019
Purpose of ReviewArticular chondrocytes are exclusively responsible for the turnover of the extracellular matrix (ECM) of hyaline cartilage. However, chondrocytes are phenotypically unstable and, if they de-differentiate into hypertrophic or fibroblastic
A. Hall
semanticscholar   +1 more source