Results 61 to 70 of about 118,065 (344)

Mesenchymal stem cell-derived extracellular vesicles prevent the development of osteoarthritis via the circHIPK3/miR-124-3p/MYH9 axis

Journal of Nanobiotechnology, 2021
Background Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration.
Shenglong Li, Jie Liu, Siyu Liu, Weijie Jiao, Xiaohong Wang   +4 more
doaj   +1 more source

Urolithin A Protects Chondrocytes From Mechanical Overloading-Induced Injuries

Frontiers in Pharmacology, 2021
Physiological mechanical stimulation has been shown to promote chondrogenesis, but excessive mechanical loading results in cartilage degradation. Currently, the underlying mechanotransduction pathways in the context of physiological and injurious loading
Yuchen He, Yuchen He, Lauren Yocum, Peter G Alexander, Michael J Jurczak, Hang Lin, Hang Lin, Hang Lin   +7 more
doaj   +1 more source

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Latest Advances in Chondrocyte-Based Cartilage Repair

Biomedicines
Chondrocyte-based cell therapy has been used for more than 30 years and is still considered to be a promising method of cartilage repair despite some limitations.
Li Yue, Ryan Lim, Brett D. Owens
doaj   +1 more source

MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12

Cell Death and Disease, 2018
Chondrocyte loss is a prominent feature of osteoarthritis (OA). Autophagy is indispensable in maintaining the metabolic activities of cells exposed to deleterious stress.
W. Lian, J. Ko, Re-Weng Wu, Yi‐Chih Sun, Yu-Shan Chen, Shin-Long Wu, L. Weng, H. Jahr, Feng-Sheng Wang   +8 more
semanticscholar   +1 more source

Anionic Citrate‐Based 3D‐Printed Scaffolds for Tunable and Sustained Orthobiologic Delivery to Enhance Tissue Regeneration

Advanced Functional Materials, EarlyView.
A potent anionic citric acid‐based 3D‐printed scaffold is developed for the sustained and controlled release of orthobiologics to enhance orthopedic therapeutic efficacy. Comprehensive in vivo studies demonstrated effective bone fusion and high safety at a low dose of BMP‐2 delivered by the system, establishing it as a promising platform for safe ...
Se‐Hwan Lee, Ruqiang Lu, Andrew House, Zizhao Li, Lindsey Hammond Burton, Katie Josephine Sikes, Lynn Marie Pezzanite, Drew William Koch, Kevin Michael Labus, Ben Gadomski, Jeremiah Easley, Richard Tuan Tran, Su Chin Heo   +12 more
wiley   +1 more source

Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis

Bioengineering
Osteoarthritis (OA) is a common joint disease characterized by pain and functional impairment, which severely impacts the quality of life of middle-aged and elderly individuals.
Da-Long Dong, Guang-Zhen Jin
doaj   +1 more source

The properties of bioengineered chondrocyte sheets for cartilage regeneration

BMC Biotechnology, 2009
Background Although the clinical results of autologous chondrocyte implantation for articular cartilage defects have recently improved as a result of advanced techniques based on tissue engineering procedures, problems with cell handling and scaffold ...
Ota Naoshi, Ishihara Miya, Kaneshiro Nagatoshi, Lee Jeong IK, Sato Masato, Mitani Genya, Kokubo Mami, Sakai Hideaki, Kikuchi Tetsutaro, Mochida Joji   +9 more
doaj   +1 more source

Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment

eLife, 2021
Chondrocytes in the resting zone of the postnatal growth plate are characterized by slow cell cycle progression, and encompass a population of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells that contribute to the formation of ...
Shawn A Hallett, Yuki Matsushita, Wanida Ono, Naoko Sakagami, Koji Mizuhashi, Nicha Tokavanich, Mizuki Nagata, Annabelle Zhou, Takao Hirai, Henry M Kronenberg, Noriaki Ono   +10 more
doaj   +1 more source

The Signaling Pathways Involved in Chondrocyte Differentiation and Hypertrophic Differentiation

Stem Cells International, 2016
Chondrocytes communicate with each other mainly via diffusible signals rather than direct cell-to-cell contact. The chondrogenic differentiation of mesenchymal stem cells (MSCs) is well regulated by the interactions of varieties of growth factors ...
Jianmei Li, S. Dong
semanticscholar   +1 more source