Results 61 to 70 of about 131,500 (355)
Scientific Reports, 2016 Circular RNAs (circRNAs) are involved in the development of various diseases, but there is little knowledge of circRNAs in osteoarthritis (OA). The aim of study was to identify circRNA expression in articular cartilage and to explore the function of ...
Qiang Liu +6 more
semanticscholar +1 more source
Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis
BioengineeringOsteoarthritis (OA) is a common joint disease characterized by pain and functional impairment, which severely impacts the quality of life of middle-aged and elderly individuals.
Da-Long Dong, Guang-Zhen Jin
doaj +1 more source
Cell Calcification Models and Their Implications for Medicine and Biomaterial Research
Advanced Healthcare Materials, EarlyView.Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter +5 more
wiley +1 more source
Cell Death and Disease, 2018 Chondrocyte loss is a prominent feature of osteoarthritis (OA). Autophagy is indispensable in maintaining the metabolic activities of cells exposed to deleterious stress.
W. Lian +8 more
semanticscholar +1 more source
Bone ResearchChondrocyte senescence is a critical pathological hallmark of osteoarthritis (OA). Aberrant mechanical stress is considered a pivotal determinant in chondrocyte aging; however, the precise underlying mechanism remains elusive.
Xiangyu Zu +8 more
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Latest Advances in Chondrocyte-Based Cartilage Repair
BiomedicinesChondrocyte-based cell therapy has been used for more than 30 years and is still considered to be a promising method of cartilage repair despite some limitations.
Li Yue, Ryan Lim, Brett D. Owens
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Bioprinting Organs—Science or Fiction?—A Review From Students to Students
Advanced Healthcare Materials, EarlyView.Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu +18 more
wiley +1 more source
Stem Cell Research & TherapyBackground Osteoarthritis (OA) is one of the most prevalent degenerative joint diseases, while the mechanism by which extracellular vesicles (EVs) promote chondrocyte regeneration remains unclear. The study assessed the effect of hypoxic mesenchymal stem
Haifeng Zhang +10 more
doaj +1 more source
HeliyonArticular cartilage damage and chondrocyte apoptosis are among the distinguishing features of osteoarthritis. (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) is a transient receptor potential cation channel subfamily M member 7 ...
Rendi Zhu +6 more
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The chondrocyte primary cilium [PDF]
Osteoarthritis and Cartilage, 2014 The presence and role of primary, or non-motile, cilia on chondrocytes has confused cartilage researchers for decades. Initial explanations attributed a vestigial nature to chondrocyte cilia. Evidence is now emerging that supports the role of the chondrocyte primary cilium as a sensory organelle, in particular, in mechanotransduction and as a ...
Ruhlen, R., Marberry, K.
openaire +2 more sources