Results 1 to 10 of about 244,274 (163)

DLX5 promotes Col10a1 expression and chondrocyte hypertrophy and is involved in osteoarthritis progression [PDF]

Genes and Diseases, 2023
Osteoarthritis (OA) has been considered non-reversible as articular cartilage wears down with limited repair capacity. Enhanced chondrocyte hypertrophy and increased type X collagen gene (COL10A1) expression have been associated with OA.
Jinnan Chen, Fangzhou Chen, Xuan Wu, Huiqin Bian, Chen Chen, Xiaojing Zhang, Ruoxuan Hei, XiaotongYang, Haochun Yuan, Qian Wang, Yaojuan Lu, Longwei Qiao, Qiping Zheng   +12 more
doaj   +3 more sources

Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis [PDF]

Pharmaceutics, 2021
Chondrocyte hypertrophy is one of the key indicators in the progression of osteoarthritis (OA). However, compared with other OA indications, such as cartilage collapse, sclerosis, inflammation, and protease activation, the mechanisms by which chondrocyte
Sunghyun Park, Alvin Bello, Yoshie Arai, Jinsung Ahn, Dohyun Kim, Kyung-Yup Cha, Inho Baek, Hansoo Park, Soo-Hong Lee   +8 more
doaj   +3 more sources

Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis [PDF]

Bioengineering
Osteoarthritis (OA) is a common joint disease characterized by pain and functional impairment, which severely impacts the quality of life of middle-aged and elderly individuals.
Da-Long Dong, Guang-Zhen Jin
doaj   +3 more sources

Suppressing Chondrocyte Hypertrophy to Build Better Cartilage [PDF]

Bioengineering, 2023
Current clinical strategies for restoring cartilage defects do not adequately consider taking the necessary steps to prevent the formation of hypertrophic tissue at injury sites.
Christian Shigley, Jay Trivedi, Ozair Meghani, Brett D. Owens, Chathuraka T. Jayasuriya   +4 more
doaj   +3 more sources

The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation [PDF]

npj Regenerative Medicine, 2022
During the development of the appendicular skeleton, the cartilaginous templates undergo hypertrophic differentiation and remodels into bone, except for the cartilage most adjacent to joint cavities where hypertrophic differentiation and endochondral ...
Michael Chau, Zelong Dou, Marta Baroncelli, Ellie B. Landman, Ameya Bendre, Masaru Kanekiyo, Alexandra Gkourogianni, Kevin Barnes, Lars Ottosson, Ola Nilsson   +9 more
doaj   +3 more sources

SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression [PDF]

npj Regenerative Medicine, 2021
Osteoarthritis (OA) causes serious changes in the metabolic and signaling pathways of chondrocytes, including the mitogen-activated protein kinase (MAPK) pathway.
Sunghyun Park, Yoshie Arai, Alvin Bello, Hansoo Park, Dohyun Kim, Kyung-Soon Park, Soo-Hong Lee   +6 more
doaj   +3 more sources

M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis [PDF]

Journal of Nanobiotechnology
Osteoarthritis (OA) is one of the most prevalent chronic musculoskeletal diseases among the elderly population. In this study, macrophage-derived exosomes were isolated and identified.
Yufan Qian, Genglei Chu, Lei Zhang, Zhikai Wu, Qiuyuan Wang, Jiong Jiong Guo, Feng Zhou   +6 more
doaj   +3 more sources

Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans [PDF]

Bone Research
Osteoarthritis (OA) is a degenerative joint disease accompanied with the loss of cartilage and consequent nociceptive symptoms. Normal articular cartilage maintains at aneural state.
Shishu Huang, Dashuang Gao, Zhenxia Li, Hongchen He, Xi Yu, Xuanhe You, Diwei Wu, Ze Du, Jiancheng Zeng, Xiaojun Shi, Qinshen Hu, Yong Nie, Zhong Zhang, Zeyu Luo, Duan Wang, Zhihe Zhao, Lingli Li, Guanglin Wang, Liping Wang, Zongke Zhou, Di Chen, Fan Yang   +21 more
doaj   +3 more sources

The Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy [PDF]

Journal of Inflammation Research, 2022
Zhengquan Dong,1 Zhou Ma,1 Meiju Yang,2 Linlin Cong,2 Ruipeng Zhao,1 Liyun Cheng,3 Jian Sun,1 Yunfei Wang,1 Ruijia Yang,2 Xiaochun Wei,1 Pengcui Li1 1Department of Orthopaedic, Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, The Second ...
Dong Z, Ma Z, Yang M, Cong L, Zhao R, Cheng L, Sun J, Wang Y, Yang R, Wei X, Li P   +10 more
doaj   +3 more sources

The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression [PDF]

International Journal of Molecular Sciences, 2020
Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage.
Yeri Alice Rim, Yoojun Nam, Ji Hyeon Ju
exaly   +3 more sources