Results 101 to 110 of about 244,346 (227)

Transcription Factors in Cartilage Homeostasis and Osteoarthritis

Biology, 2020
Osteoarthritis (OA) is the most common degenerative joint disease, and it is characterized by articular cartilage loss. In part, OA is caused by aberrant anabolic and catabolic activities of the chondrocyte, the only cell type present in cartilage. These
Margot Neefjes, Arjan P. M. van Caam, Peter M. van der Kraan   +2 more
doaj   +1 more source

Insulin-like growth factor I (IGF-1) Ec/Mechano Growth factor--a splice variant of IGF-1 within the growth plate. [PDF]

PLoS ONE, 2013
Human insulin-like growth factor 1 Ec (IGF-1Ec), also called mechano growth factor (MGF), is a splice variant of insulin-like growth factor 1 (IGF-1), which has been shown in vitro as well as in vivo to induce growth and hypertrophy in mechanically ...
Werner Schlegel, Adalbert Raimann, Daniel Halbauer, Daniela Scharmer, Susanne Sagmeister, Barbara Wessner, Magdalena Helmreich, Gabriele Haeusler, Monika Egerbacher   +8 more
doaj   +1 more source

Suppression of Hypertrophy During in vitro Chondrogenesis of Cocultures of Human Mesenchymal Stem Cells and Nasal Chondrocytes Correlates With Lack of in vivo Calcification and Vascular Invasion

Frontiers in Bioengineering and Biotechnology, 2021
ObjectiveHuman nasal septal chondrocytes (NC) are a promising minimally invasive derivable chondrogenic cell source for cartilage repair. However, the quality of NC-derived cartilage is variable between donors. Coculture of NC with mesenchymal stem cells
Matthew Anderson-Baron, Matthew Anderson-Baron, Yan Liang, Yan Liang, Melanie Kunze, Melanie Kunze, Aillette Mulet-Sierra, Aillette Mulet-Sierra, Martin Osswald, Martin Osswald, Khalid Ansari, Hadi Seikaly, Adetola B. Adesida, Adetola B. Adesida, Adetola B. Adesida   +14 more
doaj   +1 more source

Multiple Phases of Chondrocyte Enlargement Underlie Differences in Skeletal Proportions [PDF]

, 2014
Even a casual pass through the great halls of mammals in the world’s natural history museums highlights the wide diversity of skeletal proportions that allow us to distinguish between species even when reduced to their calcified components.
Cooper, Kimberly L., Dasari, Ramachandra R., Kirschner, Marc W., Oh, Seungeun, Sung, Yongjin, Tabin, Clifford J.   +5 more
core   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Regulation of class IIa HDAC activities: It is not only matter of subcellular localization [PDF]

, 2016
In response to environmental cues, enzymes that influence the functions of proteins, through reversible post-translational modifications supervise the coordination of cell behavior like orchestral conductors. Class IIa histone deacetylases (HDACs) belong
Brancolini, Claudio, DI GIORGIO, Eros
core   +1 more source

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

Advanced Science, EarlyView.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng, Yunsheng Jiang, Zhiyu Chen, Kaiquan Chen, Na Cao, Yang Huang, Zhengxue Quan, Cheng Chen   +7 more
wiley   +1 more source

Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered

Bone Reports, 2018
There are several pitfalls associated with research based on transgenic mice. Here, we describe our interpretation and analysis of mTORC1 activation in growth plate chondrocytes and compare these to a recent publication (Yan et al., Nature Communications
Phillip T. Newton, Meng Xie, Ekaterina V. Medvedeva, Lars Sävendahl, Andrei S. Chagin   +4 more
doaj   +1 more source

New treatment strategies for growth failure caused by chronic inflammation in children [PDF]

, 2013
Chronic inflammation during childhood often leads to impaired bone growth and reduced height in adulthood. Interleukin-1β (IL-1β), interleukin-6 (IL-6) and the tumour necrosis factor-α (TNF-α) are pro-inflammatory cytokines up-regulated during chronic ...
Fernández Vojvodich, Paola
core   +1 more source

Stromal Cell-Derived Factor 1 Regulates the Actin Organization of Chondrocytes and Chondrocyte Hypertrophy

PLoS ONE, 2012
Stromal cell-derived factor 1 (SDF-1/CXCL12/PBSF) plays important roles in the biological and physiological functions of haematopoietic and mesenchymal stem cells. This chemokine regulates the formation of multiple organ systems during embryogenesis. However, its roles in skeletal development remain unclear.
Koichi Murata, Toshiyuki Kitaori, Shinya Oishi, Naoki Watanabe, Hiroyuki Yoshitomi, Shimei Tanida, Masahiro Ishikawa, Takashi Kasahara, Hideyuki Shibuya, Nobutaka Fujii, Takashi Nagasawa, Takashi Nakamura, Hiromu Ito   +12 more
openaire   +4 more sources