Results 121 to 130 of about 244,346 (227)

Fibroblast growth factor signaling in skeletal development and disease [PDF]

, 2015
Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate skeletal development. FGF signaling regulates development of the limb bud and formation of the mesenchymal condensation and has key roles in regulating ...
Marie, Pierre J, Ornitz, David M
core   +2 more sources

Minced cartilage implantation provides comparable outcomes to autologous chondrocyte implantation (ACI) for knee cartilage lesions: A matched‐pair analysis

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To compare short‐term patient‐reported outcomes (PROMs) and revision rates between autologous hand‐minced cartilage implantation (MCI) and autologous chondrocyte implantation (ACI) for knee cartilage lesions. Methods All patients undergoing MCI or ACI at a single centre were retrospectively analysed from a prospectively maintained ...
Armin Runer, Louis Leuthard, Luisa Hoheisel, Vincent A. Stadelmann, Stefan Preiss, Gian M. Salzmann, Jakob Hax   +6 more
wiley   +1 more source

IGF-I signalling in bone growth:inhibitory actions of dexamethasone and IL-1beta [PDF]

, 2007
To determine if glucocorticoids and proinflammatory cytokines inhibit bone growth through a common mechanism involving impaired IGF-I ...
Ahmed, S.F., Ahmed, S.F., Farquharson, C., Macrae, V.E., Mushtaq, T.   +4 more
core   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Chondrogenic Potential of Subpopulations of Cells Expressing Mesenchymal Stem Cell Markers Derived from Human Synovial Membranes [PDF]

, 2010
[Abstract] In this study we analyzed the chondrogenic potential of subpopulations of mesenchymal stem cells (MSCs) derived from human synovial membranes enriched for CD73, CD106, and CD271 markers.
Arufe, M.C., Blanco García, Francisco J, De-Toro, Javier, Fuente, Alexandre de la, Fuentes Boquete, Isaac Manuel   +4 more
core   +2 more sources

Regulation of chondrocyte hypertrophy in an osteochondral interface mimicking gel matrix

Colloids and Surfaces B: Biointerfaces, 2020
Calcified cartilage extracellular matrix (ECM) is a critical interface at the osteochondral junction which plays an important role in maintaining the structural continuity between articular cartilage and subchondral bone. This mineralized network is primarily composed of glycosaminoglycans (GAGs) and collagen type II (col II) and hosts hypertrophic ...
Serdar Korpayev, Özge Toprak, Gülşah Kaygusuz, Murat Şen, Kaan Orhan, Ayşe Karakeçili   +5 more
openaire   +3 more sources

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Genome-wide microRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR-140-5p [PDF]

, 2015
microRNAs (miRNAs) are abundantly expressed in development where they are critical determinants of cell differentiation and phenotype. Accordingly miRNAs are essential for normal skeletal development and chondrogenesis in particular.
Akiyama, Albers, Baek, Baraniskin, Bartel, Barter, Berschneider, Bhushan, Bi, Boland, Chiang, Chun, DeLise, Djebali, Dongen, Eberhart, Ebert, Feigin, Friedman, Fu, Furumatsu, Golan, Gradus, Grumolato, Hwang, Jenkins, Kai, Kanamori, Karlsen, Karlsson, Kolben, Korinek, Krol, Laine, Lalevee, Li, Li, Liu, Liu, Lyons, Miyaki, Miyaki, Murdoch, Nakamura, Onyekwelu, Pais, Parikh, Pittenger, Radwan, Roelofs, Rui, Schulz, Smyth, Song, Sorrentino, Staines, Sumiyoshi, Swingler, Tardif, Taylor, Tuddenham, Vonk, Wang, Wang, Xu, Yamashita, Yang, Yang, Yano, Yuan, Zeybel, Zhang, Zhang   +72 more
core   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

FasL Expression in Articular Discs of Human Temporomandibular Joint and Association with Osteoarthrosis [PDF]

, 2013
Background Apoptosis is a programme of cell death which does not induce an inflammatory response. Recent previous research has suggested a correlation between temporomandibular internal derangement and apoptosis.
Alanis, Luciana Reis Azevedo, Almeida, Luis Eduardo, Ambros, Viviane, Azevedo, Marina, Camejo, Flavio de Alcantara, Caporal, Karina Sao Thiago, Doetzer, Andrea, Noronha, Lucia, Olandoski, Marcia, Trevilatto, Paula C.   +9 more
core   +2 more sources