Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis [PDF]
Stem Cells Translational Medicine, 2020 Chondrocyte hypertrophy‐like change is an important pathological process of osteoarthritis (OA), but the mechanism remains largely unknown. Neural cell adhesion molecule (NCAM) is highly expressed and involved in the chondrocyte differentiation of ...
Bin‐Feng Cheng +9 more
doaj +3 more sources
PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy. [PDF]
JCI Insight, 2019 During endochondral bone formation, chondrocyte hypertrophy represents a crucial turning point from chondrocyte differentiation to bone formation. Both parathyroid hormone-related protein (PTHrP) and histone deacetylase 4 (HDAC4) inhibit chondrocyte ...
Nishimori S +7 more
europepmc +4 more sources
Stiffened fibre-like microenvironment based on patterned equidistant micropillars directs chondrocyte hypertrophy. [PDF]
Mater Today Bio, 2023 Articular cartilage, composed of collagen type II as a major extracellular matrix and chondrocyte as a unique cell type, is a specialized connective tissue without blood vessels, lymphatic vessels and nerves.
Duan M +9 more
europepmc +2 more sources
Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation [PDF]
Scientific Reports, 2017 Mutations in the RMRP-gene, encoding the lncRNA component of the RNase MRP complex, are the origin of cartilage-hair hypoplasia. Cartilage-hair hypoplasia is associated with severe dwarfism caused by impaired skeletal development.
Mandy M. F. Steinbusch +10 more
doaj +3 more sources
Chondrocyte Hypertrophy in Osteoarthritis: Mechanistic Studies and Models for the Identification of New Therapeutic Strategies. [PDF]
Cells, 2022 Articular cartilage shows limited self-healing ability owing to its low cellularity and avascularity. Untreated cartilage defects display an increased propensity to degenerate, leading to osteoarthritis (OA). During OA progression, articular chondrocytes
Chawla S +10 more
europepmc +2 more sources
miR-199a-5p Reduces Chondrocyte Hypertrophy and Attenuates Osteoarthritis Progression via the Indian Hedgehog Signal Pathway. [PDF]
J Clin Med, 2023 Osteoarthritis (OA), the most common type of arthritis, is an age-associated disease, characterized by the progressive degradation of articular cartilage, synovial inflammation, and degeneration of subchondral bone. Chondrocyte proliferation is regulated
Huang L +14 more
europepmc +2 more sources
Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate. [PDF]
Cell Death Dis, 2023 Genetic mutations in the Xylt1 gene are associated with Desbuquois dysplasia type II syndrome characterized by sever prenatal and postnatal short stature. However, the specific role of XylT-I in the growth plate is not completely understood.
Taieb M +3 more
europepmc +2 more sources
Anti-Dlx5 Retards the Progression of Osteoarthritis through Inhibiting Chondrocyte Hypertrophy and Apoptosis. [PDF]
Evid Based Complement Alternat Med, 2022 Osteoarthritis is a common degenerative joint disease that can cause pain and disability in patients. There is still a lack of effective treatments to improve pathological changes of osteoarthritis cartilages and reverse the progression of osteoarthritis.
Lu Y, Zhang C, Jiang S, Yuan F.
europepmc +2 more sources
HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis. [PDF]
BMC Musculoskelet Disord, 2022 Background The aim of this study was to evaluate whether histone deacetylase 4 S246/467/632A mutant (m-HDAC4) has enhanced function at histone deacetylase 4 (HDAC4) to attenuate cartilage degeneration in a rat model of osteoarthritis (OA).
Gu X, Li F, Gao Y, Che X, Li P.
europepmc +2 more sources
Septal chondrocyte hypertrophy contributes to midface deformity in a mouse model of Apert syndrome. [PDF]
Sci Rep, 2021 Midface hypoplasia is a major manifestation of Apert syndrome. However, the tissue component responsible for midface hypoplasia has not been elucidated.
Kim BS +8 more
europepmc +2 more sources