Results 21 to 30 of about 244,346 (227)

Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis. [PDF]

J Pathol, 2021
Chondrocytes in mice developing osteoarthritis (OA) exhibit an aberrant response to the secreted cytokine transforming growth factor (TGF)‐β, consisting in a potentiation of intracellular signaling downstream of the transmembrane type I receptor kinase ...
Garcia de Vinuesa A, Sanchez-Duffhues G, Blaney-Davidson E, van Caam A, Lodder K, Ramos Y, Kloppenburg M, Meulenbelt I, van der Kraan P, Goumans MJ, Ten Dijke P.   +10 more
europepmc   +2 more sources

Effect of Inflammatory Signaling on Human Articular Chondrocyte Hypertrophy: Potential Involvement of Tissue Repair Macrophages. [PDF]

Cartilage, 2021
Objective In osteoarthritis, chondrocytes tend to acquire a hypertrophic phenotype, which contributes to the modification of the extracellular matrix, resulting in permanent cartilage changes.
Ferrao Blanco MN, Bastiaansen-Jenniskens YM, Chambers MG, Pitsillides AA, Narcisi R, van Osch GJVM.   +5 more
europepmc   +2 more sources

Osteoarthritis-Related Inflammation Blocks TGF-β's Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region. [PDF]

Int J Mol Sci, 2021
Osteoarthritis (OA) is a degenerative joint disease characterized by irreversible cartilage damage, inflammation and altered chondrocyte phenotype. Transforming growth factor-β (TGF-β) signaling via SMAD2/3 is crucial for blocking hypertrophy.
Thielen N, Neefjes M, Wiegertjes R, van den Akker G, Vitters E, van Beuningen H, Blaney Davidson E, Koenders M, van Lent P, van de Loo F, van Caam A, van der Kraan P.   +11 more
europepmc   +2 more sources

Chemokine (C-C Motif) Ligand 2/Chemokine Receptor 2 (CCR2) Axis Blockade to Delay Chondrocyte Hypertrophy as a Therapeutic Strategy for Osteoarthritis. [PDF]

Med Sci Monit, 2021
Background Chondrocytes play a vital role in the later stages of osteoarthritis (OA). The roles of chemokine (C-C motif) ligand 2 (CCL2) and its receptor, chemokine receptor 2 (CCR2), are as yet poorly elucidated in chondrocyte hypertrophy (CH). Here, we
Wang Z, Wang B, Zhang J, Wu Z, Yu L, Sun Z.   +5 more
europepmc   +2 more sources

Bibliometric analysis of research trends and emerging insights of osteoarthritis and chondrocyte hypertrophy [PDF]

Frontiers in Surgery
BackgroundThis study aims to systematically analyze the intersection of OA and chondrocyte hypertrophy using bibliometric methods, providing an quantitative and comprehensive overview of the current research status and emerging trends in this field ...
Jiajin Fang, Jiajin Fang, Shuai Wang
doaj   +2 more sources

Mechanical compression induces chondrocyte hypertrophy by regulating Runx2 O-GlcNAcylation during temporomandibular joint condyle degeneration [PDF]

Bone & Joint Research
Aims: Excessive chondrocyte hypertrophy is a common feature in cartilage degeneration which is susceptible to joint overloading, but the relationship between mechanical overloading and chondrocyte hypertrophy still remains elusive.
Yan Xiao, Zhang Yue, He Zijing, Zheng Yao, Mao Sui, Zeng Xuemin, Zhang Qiang, Yuan Xiao, Ren Dapeng   +8 more
doaj   +2 more sources

IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization [PDF]

Genes and Diseases
Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes, in which the Indian hedgehog (IHH) and parathyroid hormone-related protein-parathyroid hormone-1 receptor (PTHrP-PTH1R) feedback
Mengtian Fan, Nana Geng, Xingyue Li, Danyang Yin, Yuyou Yang, Rong Jiang, Cheng Chen, Naibo Feng, Li Liang, Xiaoli Li, Fengtao Luo, Huabing Qi, Qiaoyan Tan, Yangli Xie, Fengjin Guo   +14 more
doaj   +2 more sources

The role of histone deacetylase 4 during chondrocyte hypertrophy and endochondral bone development. [PDF]

Bone Joint Res, 2020
Chondrocyte hypertrophy represents a crucial turning point during endochondral bone development. This process is tightly regulated by various factors, constituting a regulatory network that maintains normal bone development. Histone deacetylase 4 (HDAC4)
Chen Z, Zhang Z, Guo L, Wei X, Zhang Y, Wang X, Wei L.   +6 more
europepmc   +2 more sources

Smad4 regulates growth plate matrix production and chondrocyte polarity [PDF]

Biology Open, 2017
Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Amanda T. Whitaker, Ellora Berthet, Andrea Cantu, Diana J. Laird, Tamara Alliston   +4 more
doaj   +5 more sources

Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction. [PDF]

Bone Res, 2019
Hypertrophic differentiation is not only the terminal process of endochondral ossification in the growth plate but is also an important pathological change in osteoarthritic cartilage.
Lian C, Wang X, Qiu X, Wu Z, Gao B, Liu L, Liang G, Zhou H, Yang X, Peng Y, Liang A, Xu C, Huang D, Su P.   +13 more
europepmc   +2 more sources