Results 41 to 50 of about 244,346 (227)

In Vitro Study of Licorice on IL-1β-Induced Chondrocytes and In Silico Approach for Osteoarthritis

Pharmaceuticals, 2021
Osteoarthritis (OA) is a common degenerative joint disorder that affects joint function, mobility, and pain. The release of proinflammatory cytokines stimulates matrix metalloproteinases (MMPs) and aggrecanase production which further induces articular ...
Akhtar Ali, YoungJoon Park, Jeonghoon Lee, Hyo-Jin An, Jong-Sik Jin, Jong-Hyun Lee, Jaeki Chang, Dong-Keun Kim, Bonhyuk Goo, Yeon Cheol Park, Kang-Hyun Leem, Shin Seong, Wonnam Kim   +12 more
doaj   +1 more source

Mechanics of chondrocyte hypertrophy [PDF]

Biomechanics and Modeling in Mechanobiology, 2011
Chondrocyte hypertrophy is a characteristic of osteoarthritis and dominates bone growth. Intra- and extracellular changes that are known to be induced by metabolically active hypertrophic chondrocytes are known to contribute to hypertrophy. However, it is unknown to which extent these mechanical conditions together can be held responsible for the total
Donkelaar, van, C.C., Wilson, W.
openaire   +3 more sources

WISP3 - IGF1 interaction regulates chondrocyte hypertrophy [PDF]

Journal of Cell Science, 2013
WISP3 (Wnt Induced Secreted Protein 3) is a multi-domain protein of mesenchymal origin. Mutations in several domains of WISP3 cause PPRD (Progressive Pseudo Rheumatoid Dysplasia), which is associated with cartilage loss and restricted skeletal development.
Srinivasa Rao, Repudi, Milan, Patra, Malini, Sen   +2 more
openaire   +2 more sources

The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. [PDF]

PLoS ONE, 2009
Sequential proliferation, hypertrophy and maturation of chondrocytes are required for proper endochondral bone development and tightly regulated by cell signaling.
Xizhi Guo, Kinglun Kingston Mak, Makoto M Taketo, Yingzi Yang   +3 more
doaj   +1 more source

Regulating the Regulators of Chondrocyte Hypertrophy [PDF]

Journal of Bone and Mineral Research, 1999
THE DEVELOPMENT, growth, and maintenance of a functional skeleton relies on the existence of several different types of chondrocytes with markedly different fates. The articular chondrocytes on the surface of joints are expected to persist throughout life, producing extracellular matrix components which provide a cushion to distribute load on bone at ...
S W, Volk, P S, Leboy
openaire   +2 more sources

Thyroxine downregulates Sox9 and promotes chondrocyte hypertrophy [PDF]

Biochemical and Biophysical Research Communications, 2003
Thyroid hormones exert a profound effect on development, growth, and metabolism of skeleton. In the present study, we evaluated the effects of thyroxine (T4) and growth hormone (GH) on the terminal differentiation of rib growth plate chondrocytes in three-dimensional pellet culture.
Yasunori, Okubo, A Hari, Reddi
openaire   +2 more sources

Blocking chondrocyte hypertrophy in conditional Evc knockout mice does not modify cartilage damage in osteoarthritis

The FASEB Journal, 2022
Chondrocytes in osteoarthritic (OA) cartilage acquire a hypertrophic‐like phenotype, where Hedgehog (Hh) signaling is pivotal. Hh overexpression causes OA‐like cartilage lesions, whereas its downregulation prevents articular destruction in mouse models ...
A. Lamuedra, P. Gratal, L. Calatrava, V. Ruiz-Perez, Adrián Palencia-Campos, S. Portal-Núñez, A. Mediero, G. Herrero-Beaumont, R. Largo   +8 more
semanticscholar   +1 more source

Regulation of α5 and αV Integrin Expression by GDF-5 and BMP-7 in Chondrocyte Differentiation and Osteoarthritis. [PDF]

PLoS ONE, 2015
The Integrin β1 family is the major receptors of the Extracellular matrix (ECM), and the synthesis and degradation balance of ECM is seriously disrupted during Osteoarthritis (OA).
David Garciadiego-Cázares, Hilda I Aguirre-Sánchez, René F Abarca-Buis, Juan B Kouri, Cristina Velasquillo, Clemente Ibarra   +5 more
doaj   +1 more source

Preconditioning of mesenchymal stromal cells with low-intensity ultrasound: influence on chondrogenesis and directed SOX9 signaling pathways [PDF]

, 2020
Background: Continuous low-intensity ultrasound (cLIUS) facilitates the chondrogenic differentiation of human mesenchymal stromal cells (MSCs) in the absence of exogenously added transforming growth factor-beta (TGFβ) by upregulating the expression of ...
A Argentaro, A Augello, A Katsumi, A Woods, A Woods, AD Miller, AH Huang, B Yang, BH Choi, C Huang, C Matta, CA Simmons, CB Little, CJ O’Conor, CY Huang, D Schumann, DR Haudenschild, EM Darling, F Dell'Accio, G Coricor, H Sim, H-C Hsu, HJ Kwon, HJ Lee, HJ Lee, J Li, J Puetzer, JC Sng, JD Kisiday, JH Cui, JH Cui, JW Choi, K Ebisawa, K Pelttari, L Bian, Li Ling, LJ Ng, M Shakibaei, M Tsuda, MA Corrigan, MB Mueller, N Fahy, N Thelin, NP Whitney, P Müller, R Ogawa, RL Mauck, RM Delaine-Smith, RS Tigli, S Murakami, S Noriega, S Noriega, S Yamaguchi, SD Cook, SD Cook, T Furumatsu, T Guo, T Ito, T Juhasz, T Nishida, T Sanjukta Guha, TM Louw, V Lefebvre, V Lefebvre, W Huang, W Huang, Z Li, ZJ Zhang   +67 more
core   +2 more sources

Asiatic acid attenuates hypertrophic and fibrotic differentiation of articular chondrocytes via AMPK/PI3K/AKT signaling pathway

Arthritis Research & Therapy, 2020
Background Osteoarthritis (OA), the most common joint disorder, is characterized by a progressive degradation of articular cartilage. Increasing evidence suggests that OA is closely associated with cartilage pathologies including chondrocyte hypertrophy ...
Na Liu, Dejie Fu, Junjun Yang, Pingju Liu, Xiongbo Song, Xin Wang, Rui Li, Zhenlan Fu, Jiajia Chen, Xiaoyuan Gong, Cheng Chen, Liu Yang   +11 more
doaj   +1 more source