Dlx5 Is a cell autonomous regulator of chondrocyte hypertrophy in mice and functionally substitutes for Dlx6 during endochondral ossification. [PDF]
PLoS ONE, 2009 The axial and appendicular skeleton of vertebrates develops by endochondral ossification, in which skeletogenic tissue is initially cartilaginous and the differentiation of chondrocytes via the hypertrophic pathway precedes the differentiation of ...
Hui Zhu, Andrew J Bendall
doaj +1 more source
Tackling chondrocyte hypertrophy with multifunctional nanoparticles [PDF]
Gene Therapy, 2016 Osteoarthritis (OA) is the most common form of arthritis and leads to irreversible changes in all articular tissues and associated skeletal muscle.1, 2 OA is a collection of different phenotypic sub-types involving different relative contributions of the stressors and pathogenic pathways that trigger and drive, respectively, disease development (Figure
BOTTINI, MASSIMO +3 more
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A critical bioenergetic switch is regulated by IGF2 during murine cartilage development
Communications Biology, 2022 Murine chondrocyte hypertrophy was found to require IGF2-regulated bioenergetic reprogramming, in which glucose utilization shifts from glycolysis to oxidative phosphorylation as chondrocytes mature.
Judith M. Hollander +8 more
doaj +1 more source
Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis [PDF]
Cell, 2004 Histone deacetylases (HDACs) modulate cell growth and differentiation by governing chromatin structure and repressing the activity of specific transcription factors. We showed previously that HDAC9 acts as a negative regulator of cardiomyocyte hypertrophy and skeletal muscle differentiation.
Vega, Rick B. +11 more
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The Incidence and Clinical Relevance of Graft Hypertrophy After Matrix-Based Autologous Chondrocyte Implantation [PDF]
, 2012 Background: Graft hypertrophy is the most common complication of periosteal autologous chondrocyte implantation (p-ACI). Purpose: The aim of this prospective study was to analyze the development, the incidence rate, and the persistence of graft ...
Annie Horng +7 more
core +1 more source
Journal of Tissue Engineering and Regenerative Medicine, 2021 Since chondrocyte hypertrophy greatly limits the efficiency of cartilage defects repairing via cartilage tissue engineering (CTE), it is critical to develop a functional CTE scaffold able to inhibit chondrocyte hypertrophy during this period of cartilage
Yongsheng Li +7 more
semanticscholar +1 more source
XBP1S associates with RUNX2 and regulates chondrocyte hypertrophy. [PDF]
Journal of Biological Chemistry, 2012 BMP2 (bone morphogenetic protein 2) is known to activate unfolded protein response signaling molecules, including XBP1S and ATF6. However, the influence on XBP1S and ATF6 in BMP2-induced chondrocyte differentiation has not yet been elucidated. In this study, we demonstrate that BMP2 mediates mild endoplasmic reticulum stress-activated ATF6 and directly
Yanna, Liu +6 more
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c-Maf Transcription Factor Regulates ADAMTS-12 Expression in Human Chondrogenic Cells. [PDF]
, 2013 ObjectiveADAMTS (a disintegrin and metalloproteinase with thrombospondin type-1 motif) zinc metalloproteinases are important during the synthesis and breakdown of cartilage extracellular matrix.
Amanatullah, Derek F +4 more
core +2 more sources
The regulation of differentiation in mesenchymal stem cells [PDF]
, 2010 Peer reviewedPublisher ...
Augello, Andrea, De Bari, Cosimo
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Lipid phosphatase SHIP-1 regulates chondrocyte hypertrophy and skeletal development. [PDF]
J Cell Physiol, 2020 AbstractSH2‐containing inositol‐5′‐phosphatase‐1 (SHIP‐1) controls the phosphatidylinositol‐3′‐kinase (PI3K) initiated signaling pathway by limiting cell membrane recruitment and activation of Akt. Despite the fact that many of the growth factors important to cartilage development and functions are able to activate the PI3K signal transduction pathway,
So EY +9 more
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