Results 61 to 70 of about 244,346 (227)

Molecular mechanisms of long bone growth and chondrocyte regulation: A narrative review [PDF]

Precision and Future Medicine, 2023
Long bone growth is a fundamental determinant of final height. Growth, metabolism, and differentiation of chondrocytes, which are the key cellular players in this process, are regulated by systemic hormones, local factors, and cellular signaling pathways.
Eungu Kang
doaj   +1 more source

A homeostatic function of CXCR2 signalling in articular cartilage [PDF]

, 2014
Funding This work was funded by Arthritis Research UK (grants 17859, 17971, 19654), INNOCHEM EU FP6 (grant LSHB-CT-2005-51867), MRC (MR/K013076/1) and the William Harvey Research FoundationPeer reviewedPublisher ...
Aberdeen, Bertrand, J, Brandolini, L, De Bari, C, Dell'Accio, F, Dompe SPA, Karystinou, A, KU Leuven, Luyten, F P, Muenster, Nalesso, G, Pap, T, Pitsillides, A A, Pitzalis, C, Poulet, B, Queen Mary London, Sherwood, J, UCL   +17 more
core   +3 more sources

The inhibitory effect of salmon calcitonin on tri-iodothyronine induction of early hypertrophy in articular cartilage. [PDF]

PLoS ONE, 2012
Salmon calcitonin has chondroprotective effect both in vitro and in vivo, and is therefore being tested as a candidate drug for cartilage degenerative diseases.
Pingping Chen-An, Kim Vietz Andreassen, Kim Henriksen, Yadong Li, Morten Asser Karsdal, Anne-Christine Bay-Jensen   +5 more
doaj   +1 more source

Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis [PDF]

, 2017
Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate ...
Fantauzzi, Claudia Blasetti, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe   +3 more
core   +2 more sources

MEF2C Transcription Factor Controls Chondrocyte Hypertrophy and Bone Development [PDF]

Developmental Cell, 2007
Chondrocyte hypertrophy is essential for endochondral bone development. Unexpectedly, we discovered that MEF2C, a transcription factor that regulates muscle and cardiovascular development, controls bone development by activating the gene program for chondrocyte hypertrophy.
Arnold, Michael A., Kim, Yuri, Czubryt, Michael P., Phan, Dillon, McAnally, John, Qi, Xiaoxia, Shelton, John M., Richardson, James A., Bassel-Duby, Rhonda, Olson, Eric N.   +9 more
openaire   +2 more sources

Mussel-inspired cortical bone-adherent bioactive composite hydrogels promote bone augmentation through sequential regulation of endochondral ossification

Materials Today Bio, 2023
Endochondral ossification (ECO) plays an integral part in bone augmentation, which undergoes sequential processes including mesenchymal stem cells (MSC) condensation, chondrocyte differentiation, chondrocyte hypertrophy, and mineralized bone formation ...
Shuyi Tan, Yonghao Qiu, Huacui Xiong, Chunhui Wang, Yifan Chen, Wangxi Wu, Zhen Yang, Fujian Zhao   +7 more
doaj   +1 more source

implications for joint remodeling in AS [PDF]

, 2015
Introduction In ankylosing spondylitis (AS), joint remodeling leading to joint ankylosis involves cartilage fusion. Here, we analyzed whether chondrocyte hypertrophy is involved in cartilage fusion and subsequent joint remodeling in AS.
Appel, Heiner, Bleil, Janine, Hempfing, Axel, Maier, René, Schlichting, Uwe, Sieper, Joachim, Syrbe, Uta   +6 more
core   +1 more source

Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification [PDF]

The Journal of Experimental Medicine, 2007
Chondrocyte hypertrophy during endochondral ossification is a well-controlled process in which proliferating chondrocytes stop proliferating and differentiate into hypertrophic chondrocytes, which then undergo apoptosis. Chondrocyte hypertrophy induces angiogenesis and mineralization.
Morita, Kozo, Miyamoto, Takeshi, Fujita, Nobuyuki, Kubota, Yoshiaki, Ito, Keisuke, Takubo, Keiyo, Miyamoto, Kana, Ninomiya, Ken, Suzuki, Toru, Iwasaki, Ryotaro, Yagi, Mitsuru, Takaishi, Hironari, Toyama, Yoshiaki, Suda, Toshio   +13 more
openaire   +2 more sources

The chondro-osseous continuum: is it possible to unlock the potential assigned within? [PDF]

, 2018
Endochondral ossification (EO), by which long bones of the axial skeleton form, is a tightly regulated process involving chondrocyte maturation with successive stages of proliferation, maturation, and hypertrophy, accompanied by cartilage matrix ...
Adams, Aizawa, Akintoye, Amling, Bahney, Ballock, Behonick, Boegård, Brachet, Cancedda, Candeliere, Carames, Clarkin, Colnot, Colnot, Day, Dodds, Emons, Enishi, Erenpreisa, Farnum, Farnum, Felson, Galotto, Gebhard, Gerstenfeld, Gibson, Gibson, Hall, Holmbeck, Hu, Hughes, Hunter, Javaheri, Jing, Johnell, Karaplis, Kawaguchi, Kuttapitiya, Lavigne, Lian, Lieu, Mackie, Maeda, Maes, Maes, Marigo, Moskalewski, Murphy, Ono, Ortega, Park, Pottenger, Poulet, Provot, Rawlinson, Riminucci, Roach, Roach, Roach, Shah, Shapiro, Silbermann, Song, Stafford, Stickens, Thesingh, Tsang, Van der Stricht, Vortkamp, Vu, Wade-Gueye, Wang, Woolf, Yang, Yoshioka, Zelzer, Zenmyo, Zhou, Zhou   +79 more
core   +3 more sources

Runx2 is required for hypertrophic chondrocyte mediated degradation of cartilage matrix during endochondral ossification

Matrix Biology Plus, 2021
The RUNX2 transcription factor is a key regulator for the development of cartilage and bone. Global or resting chondrocyte-specific deletion of the Runx2 gene results in failure of chondrocyte hypertrophy, endochondral ossification, and perinatal ...
Harunur Rashid, Haiyan Chen, Amjad Javed
doaj   +1 more source