Differential effects of ERK and p38 signaling in BMP-2 stimulated hypertrophy of cultured chick sternal chondrocytes [PDF]
, 2005 Background During endochondral bone formation, the hypertrophy of chondrocytes is accompanied by selective expression of several genes including type X collagen and alkaline phosphatase.
Golden, E.B. +3 more
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Chondrocyte hypertrophy in skeletal development, growth, and disease
Birth Defects Research Part C: Embryo Today: Reviews, 2014 Most of our bones form through the process of endochondral ossification, which is tightly regulated by the activity of the cartilage growth plate. Chondrocyte maturation through the various stages of growth plate physiology ultimately results in hypertrophy.
Sun, Margaret Man Ger, Beier, Frank
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BMP2 and TGF-β Cooperate Differently during Synovial-Derived Stem-Cell Chondrogenesis in a Dexamethasone-Dependent Manner [PDF]
, 2019 Recent studies highlighting mesenchymal stem cell (MSC) epigenetic memory suggest that a different differentiation medium may be required depending on the tissue of origin.
Alini, Mauro +7 more
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Induction and prevention of chondrocyte hypertrophy in culture. [PDF]
The Journal of cell biology, 1989 Primary chondrocytes from whole chick embryo sterna can be maintained in suspension culture stabilized with agarose for extended periods of time. In the absence of FBS, the cells remain viable only when seeded at high densities. They do not proliferate at a high rate but they deposit extracellular matrix with fibrils resembling those of authentic ...
P, Bruckner +6 more
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PPAR gamma/mTOR signalling: striking the right balance in cartilage homeostasis [PDF]
, 2015 This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work ...
Afif +23 more
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Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis [PDF]
, 2018 Objectives: Cellular energy metabolism is important for the function of all tissues, including cartilage. Recent studies indicate that superficial and deep subpopulations of articular chondrocytes (ACs) have distinct metabolic profiles.
O\u27Keefe, Regis J +3 more
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Tyrosine kinases regulate chondrocyte hypertrophy
Osteoarthritis and Cartilage, 2021 Biomaterials & Tissue ...
Ferrao Blanco, M. N. (author) +3 more
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Treatment of failed articular cartilage reconstructive procedures of the knee: A systematic review [PDF]
, 2018 Background: Symptomatic articular cartilage lesions of the knee are common and are being treated surgically with increasing frequency. While many studies have reported outcomes following a variety of cartilage restoration procedures, few have ...
Lamplot, Joseph D +2 more
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Identification and characterization of up-regulated genes during chondrocyte hypertrophy [PDF]
Developmental Dynamics, 1996 Chondrocyte hypertrophy involves de novo acquisition and/or increased expression of certain gene products including, among others, type X collagen, alkaline phosphatase, and matrix metalloproteinases. To analyze further the genetic program associated with chondrocyte hypertrophy, we have employed a modification of the polymerase chain reaction-mediated
M, Nurminskaya, T F, Linsenmayer
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Chondrogenic potential of human articular chondrocytes and skeletal stem cells: a comparative study
, 2014 Regenerative medicine strategies have increasingly focused on skeletal stem cells (SSCs), in response to concerns such as donor site morbidity, dedifferentiation and limited lifespan associated with the use of articular chondrocytes for cartilage repair.
Li, Siwei +3 more
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