Computational modeling of the mechanical modulation of the growth plate by sustained loading [PDF]
, 2012 This paper presents a computational model that describes the growth of the bone as a function of the proliferation and hypertrophy of chondrocytes in the growth plate. We have included the effects of the mechanical loads on the sizes of the proliferative
Carlos A Narváez-Tovar +1 more
core +1 more source
KLF10 is a modulatory factor of chondrocyte hypertrophy in developing skeleton.
Journal of Orthopaedic Research, 2020 To define the functional role of Krüppel-like factor (KLF) 10 as a modulator of chondrocyte hypertrophy in developing skeleton, the developmental features in the long bone of KLF10 knockout (KO) mice were investigated and the mesenchymal stem cells (MSCs)
Jong Min Lee +5 more
semanticscholar +1 more source
Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy [PDF]
Development, 2008 Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of chondrocyte hypertrophy is also required in postnatal cartilage homeostasis. Indian hedgehog (Ihh) and PTHrP signaling play crucial roles in regulating the onset of chondrocyte hypertrophy by forming a negative feedback loop, in which Ihh ...
Kinglun Kingston, Mak +4 more
openaire +2 more sources
Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction
Advanced Functional Materials, EarlyView.Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch +13 more
wiley +1 more source
Thyroxine is the serum factor that regulates morphogenesis of columnar cartilage from isolated chondrocytes in chemically defined medium. [PDF]
, 1994 Epiphyseal chondrocytes cultured in a medium containing 10% serum may be maintained as three dimensional aggregates and differentiate terminally into hypertrophic cells.
Ballock, RT, Reddi, AH
core
Cell sources for articular cartilage repair strategies: shifting from mono-cultures to co-cultures [PDF]
, 2013 The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In recent years cartilage tissue engineering has shown great promise.
Blitterswijk, C.A. van +4 more
core +3 more sources
Hypoxia promotes redifferentiation and suppresses markers of hypertrophy and degeneration in both healthy and osteoarthritic chondrocytes [PDF]
, 2013 INTRODUCTION: Hypoxia is considered to be a positive influence on the healthy chondrocyte phenotype and cartilage matrix formation. However, hypoxia-inducible factors (HIFs) have been implicated in the pathogenesis of osteoarthritis (OA).
Brandon D Markway +2 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen +9 more
wiley +1 more source
Cell Transplantation, 1993 Syngeneic rat chondrocytes isolated from the articular-epiphyseal cartilage complex were suspended in hyaluronic acid and transplanted intramuscularly or into joint surface defects. Transplants were fixed in ruthenium hexammonium trichloride and embedded
Stanislaw Moskalewski +3 more
doaj +1 more source
HISTOCHEMICAL STUDY OF MITOCHONDRIA IN THE FEMUR DEVELOPMENT OF PIGEON EMBRYO (Columba livia ) [PDF]
Basrah Journal of Veterinary Research, 2016 Twenty fertilized eggs of pigeon (Columba livia) embryo were collected from localmarkets and pigeon breeders in Basrah governorate.They incubated in eggs incubator .The studycomprised histochemical description of mitochondria decreasing and increasing in
Khansa M. Jawad +2 more
doaj +1 more source