Results 11 to 20 of about 1,182,907 (370)

Smad4 regulates growth plate matrix production and chondrocyte polarity [PDF]

Biology Open, 2017
Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Amanda T. Whitaker, Ellora Berthet, Andrea Cantu, Diana J. Laird, Tamara Alliston   +4 more
doaj   +5 more sources

P-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axis [PDF]

Journal of Orthopaedic Surgery and Research, 2023
Background The disruption of chondrocyte proliferation and differentiation is a critical event during the process of joint injury in osteoarthritis (OA).
Yuanli Li, Junlan Nie, Changgong Deng, Hong Li   +3 more
doaj   +2 more sources

Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes [PDF]

Journal of Animal Science and Biotechnology, 2012
Background Fibroblast growth factor receptor 3 (FGFR3) inhibits growth-plate chondrocyte proliferation and limits bone elongation. Gain-of-function FGFR3 mutations cause dwarfism, reduced telomerase activity and shorter telomeres in growth plate ...
Smith Logan B, Belanger Janelle M, Oberbauer Anita M   +2 more
doaj   +2 more sources

BMSC-derived exosomes from congenital polydactyly tissue alleviate osteoarthritis by promoting chondrocyte proliferation. [PDF]

Cell Death Discov, 2020
In the past decade, mesenchymal stem cells (MSCs) have been widely used for the treatment of osteoarthritis (OA), and exosomes may play a major role. Here, we acquired a special kind of MSCs from the bone marrow of surgically resected tissue from the ...
Zhou X, Liang H, Hu X, An J, Ding S, Yu S, Liu C, Li F, Xu Y.   +8 more
europepmc   +2 more sources

Low fluid shear stress promotes chondrocyte proliferation and extracellular matrix secretion by downregulating mir-143-3p and activating the ERK5/KLF4 signaling pathway [PDF]

Scientific Reports
Low fluid shear stress (FSS, ≤ 2 dyn/cm2) has been shown to exert protective effects on chondrocytes, but the underlying molecular mechanisms remain unclear. This study aimed to elucidate the mechanisms by which FSS promotes chondrocyte proliferation and
Jun Zhao, Yayi Xia, Jinwen He
doaj   +2 more sources

Neuropeptide Y Promotes mTORC1 to Regulate Chondrocyte Proliferation and Hypertrophy.

Endocrinology, 2023
Peripheral neuropeptide Y (NPY) has been reported to regulate bone metabolism and homeostasis, however its potential roles in growth plate chondrogenesis remain unclear.
Xiaomin Kang, Xiao Ma, Huixia Li, Xinxin Jin, Xin Gao, Dongxu Feng, Shufang Wu   +6 more
semanticscholar   +3 more sources

Function and regulation of transforming growth factor β1 signalling in antler chondrocyte proliferation and differentiation. [PDF]

Cell Prolif, 2019
Chondrocyte proliferation and differentiation are crucial for endochondral ossification, but their regulatory mechanism remains unclear. The present study aimed to determine the physiological function of TGFβ1 signalling in the proliferation and ...
Ma L, Yang ZQ, Ding JL, Liu S, Guo B, Yue ZP.   +5 more
europepmc   +2 more sources

TGF-β1 promoted chondrocyte proliferation by regulating Sp1 through MSC-exosomes derived miR-135b. [PDF]

Cell Cycle, 2018
To investigate the molecular mechanism of TGF-β1 in regulating chondrocyte proliferation through MSC-exosomes, an osteoarthritis (OA) rat model was established. Cartilage degradation was quantified by using OARSI score. TGF-β1 was used to stimulate MSCs.
Wang R, Xu B, Xu H.
europepmc   +2 more sources

LncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis. [PDF]

Biosci Rep, 2019
Long non-coding RNAs (lncRNA) CASC2 is a key player in cancer biology. Our new findings showed that both lncRNA CASC2 and IL-17 were up-regulated in plasma of osteoarthritis patients.
Huang T, Wang J, Zhou Y, Zhao Y, Hang D, Cao Y.   +5 more
europepmc   +2 more sources

Effects of Bakuchiol on chondrocyte proliferation via the PI3K-Akt and ERK1/2 pathways mediated by the estrogen receptor for promotion of the regeneration of knee articular cartilage defects. [PDF]

Cell Prolif, 2019
Cartilaginous tissue degradation occurs because of the lack of survival of chondrocytes. Here, we ascertained whether bakuchiol (BAK) has the capability of activating chondrocyte proliferation.
Xu K, Xu K, Sha Y, Wang S, Chi Q, Liu Y, Wang C, Yang L.   +7 more
europepmc   +2 more sources