Results 11 to 20 of about 48,883 (320)
Smad4 regulates growth plate matrix production and chondrocyte polarity [PDF]
Biology Open, 2017 Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Amanda T. Whitaker +4 more
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Mechanical compression modulates proliferation of transplanted chondrocytes [PDF]
Journal of Orthopaedic Research, 2000 AbstractThe presence of an appropriate number of reparative cells in an articular cartilage defect is probably necessary for consistent and successful repair. Following the transplantation of chondrocytes into a defect, cell proliferation may modulate local defect cellularity.
Kelvin W. Li +6 more
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Histamine stimulates the proliferation of human articular chondrocytes in vitro and is expressed by chondrocytes in osteoarthritic cartilage [PDF]
Annals of the Rheumatic Diseases, 2003 To determine the effects of histamine on the proliferative rate of human articular chondrocytes (HAC) in vitro, and to demonstrate whether HAC in osteoarthritic (OA) cartilage express histamine and histidine decarboxylase (HDC).HAC in vitro were incubated with and without histamine in 96 well culture plates and the extent of cell proliferation was ...
L. C. Tetlow, David E. Woolley
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Dicer-dependent pathways regulate chondrocyte proliferation and differentiation [PDF]
Proceedings of the National Academy of Sciences, 2008 Small noncoding RNAs, microRNAs (miRNAs), bind to messenger RNAs through base pairing to suppress gene expression. Despite accumulating evidence that miRNAs play critical roles in various biological processes across diverse organisms, their roles in mammalian skeletal development have not been demonstrated.
Tatsuya Kobayashi +7 more
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Chondrocyte proliferation in a new culture system [PDF]
Cell Proliferation, 2009 AbstractObjective: This study has aimed to study different culture systems that might stimulate an increase in cell proliferation of normal and osteoarthritis chondrocytes from articular cartilage in rat model.Material and Methods: Three culture systems using chondrocytes embedded in alginate beads were tested: chondrocytes cultured in Dulbecco's ...
J. B. Kouri Flores +4 more
openaire +2 more sources
The viability and proliferation of human chondrocytes following cryopreservation [PDF]
The Journal of Bone and Joint Surgery. British volume, 2008 Human articular cartilage samples were retrieved from the resected material of patients undergoing total knee replacement. Samples underwent automated controlled freezing at various stages of preparation: as intact articular cartilage discs, as minced articular cartilage, and as chondrocytes immediately after enzymatic isolation from fresh articular ...
Xia, Z +4 more
openaire +7 more sources
Adipose-Derived Stem Cells Cocultured with Chondrocytes Promote the Proliferation of Chondrocytes [PDF]
Stem Cells International, 2017 Articular cartilage injury and defect caused by trauma and chronic osteoarthritis vascularity are very common, while the repair of injured cartilage remains a great challenge due to its limited healing capacity. Stem cell-based tissue engineering provides a promising treatment option for injured articular cartilage because of the cells potential for ...
Jie Shi +6 more
openaire +4 more sources
Arthritis Research & Therapy, 2023 Background Osteoarthritis (OA) is a degenerative disease related to cholesterol metabolism disorders. However, current therapies for OA are insufficient and no convincing disease-modifying OA drugs exist. Therefore, we aimed to elucidate the mechanism by
WeiBing Wang +9 more
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IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. [PDF]
, 2011 Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a key role in the pathogenesis of osteoarthritis (OA). Growth factors (GFs) capable of antagonizing the catabolic actions of cytokines may have therapeutic potential in the treatment of OA.
Aldinger, Constance +6 more
core +13 more sources
Journal of Orthopaedic Surgery and Research, 2021 Background Osteoarthritis (OA) is a joint disease characterized via destruction of cartilage. Chondrocyte damage is associated with cartilage destruction during OA.
Jipeng Lu, Zhongxiong Wu, Ying Xiong
doaj +1 more source