Results 231 to 240 of about 48,883 (320)

272 INTEGRIN LINKED KINASE-MEDIATED RAS ACTIVATION IS REQUIRED FOR MECHANOTRANSDUCTION-INDUCED PROLIFERATION AND DIFFERENTIATION IN ARTICULAR CHONDROCYTES

, 2009
Sudha Agarwal, P. Perera, S. Madhavan, J. Liu, Ewa Wypasek, Birgit Deschner   +5 more
openalex   +1 more source

Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization [PDF]

, 2015
Trevor L. Cameron, Irma Gresshoff, Katrina M. Bell, Katarzyna A. Piróg, Lisa Sampurno, Claire Hartley, Emma Sanford, Richard Wilson, Joerg Ermann, Ray Boot-Handford, Laurie H. Glimcher, Michael D. Briggs, John F. Bateman   +12 more
openalex   +1 more source

A Retinoid Antagonist Attenuates Bone Growth Inhibition Caused by Growth Plate Injury in Mice

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Growth plate injury, which may trigger growth plate fusion or arrest, is a common occurrence in pediatric orthopaedics that can lead to angulation of the limb and limb length discrepancy. Growth plate injuries are currently treated palliatively, with surgical intervention when severe limb length discrepancy or angulation is found during follow‐
Masatake Matsuoka, Ningfeng Tang, Tian Hongying, Kenta Uchibe, Satoru Otsuru, Norimasa Iwasaki, Joshua M. Abzug, Motomi Enomoto‐Iwamoto, Masahiro Iwamoto   +8 more
wiley   +1 more source

C/EBPβ Promotes Transition from Proliferation to Hypertrophic Differentiation of Chondrocytes through Transactivation of p57Kip2

, 2009
Makoto Hirata, Fumitaka Kugimiya, Atsushi Fukai, Shinsuke Ohba, Naohiro Kawamura, Toru Ogasawara, Yosuke Kawasaki, Taku Saito, Fumiko Yano, Toshiyuki Ikeda, Kozo Nakamura, Ung‐il Chung, Hiroshi Kawaguchi   +12 more
openalex   +2 more sources

COX‐2 in Fracture Callus Chondro‐Osseous Junction Osteoclasts Regulates Chondrocyte Hypertrophy and Callus Vasculogenesis

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Cyclooxygenase‐2 (COX‐2) activity is necessary for bone fracture healing to proceed normally. COX‐2 is encoded by Ptgs2 and is expressed by several cell types during fracture healing, suggesting that COX‐2 regulates multiple processes to affect fracture healing.
Marc Teitelbaum, Hsuan‐Ni Lin, Maya D. Culbertson, Charlene Wetterstrand, J. Patrick O'Connor   +4 more
wiley   +1 more source

190 ENDOTHELIAL NITRIC OXIDE SYNTHASE DEFICIENCY RESULTS IN REDUCED CHONDROCYTE PROLIFERATION AND ENDOCHONDRAL BONE GROWTH

, 2009
Qiongxian Yan
openalex   +1 more source

Longitudinal In Vivo 3T MRI of Naturally Occurring Early Osteochondrosis Lesions in the Piglet Humeral Epiphyseal Cartilage and Growth Plate

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Osteochondrosis/osteochondritis dissecans (OC/OCD) is a developmental orthopedic disease primarily affecting the knee, ankle, and elbow joints of children and multiple animal species. Subclinical lesions of OC/OCD have been described, but most can be visualized only histologically in cadaveric specimens.
Alexandra R. Armstrong, Erick O. Buko, Casey P. Johnson, Ferenc Tóth   +3 more
wiley   +1 more source

Circ_0006646 Promotes the Progression of Osteoarthritis via Upregulating CDH11 Expression in an IGF2BP2‐Dependent Manner

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative osteoarthropathy with an unclear pathogenesis. Circular RNA (circRNA) has been reported to be associated with OA progression. This study aims to explore the role and potential mechanism of hsa_circ_0006646 in OA. Interleukin‐1β (IL‐1β)‐induced human chondrocytes were used as the cell model of OA. RT‐
Ming‐Yu Hua, Guo‐Liang Wang, Wen‐Hao Duan, Xiao‐Heng Tang   +3 more
wiley   +1 more source

Monotropein Induced Ferroptosis to Alleviate the Progression of Hepatocellular Carcinoma via Regulating Nrf2/HO‐1/GPX4 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) exhibits a high global morbidity rate and ranks as the fourth leading cause of cancer‐related mortality worldwide. In response to the urgent need for effective HCC treatments, naturally occurring, botanical‐driven compounds have gained increasing attention.
Bing Shi, Yan‐Ping Li, Zhuo Gan, Pan Chen   +3 more
wiley   +1 more source

Decrease of miR-195 Promotes Chondrocytes Proliferation and Maintenance of Chondrogenic Phenotype via Targeting FGF-18 Pathway [PDF]

, 2017
Yong Wang, Tao Yang, Yadong Liu, Wei Zhao, Zhen Zhang, Ming Lu, Weiguo Zhang   +6 more
openalex   +1 more source