Results 21 to 30 of about 1,182,907 (370)

The Benefit of Minced Cartilage Over Isolated Chondrocytes in Atelocollagen Gel on Chondrocyte Proliferation and Migration. [PDF]

Cartilage, 2021
Objective Autologous chondrocyte implantation is a necessary procedure for the repair of articular cartilage defects; however, isolated chondrocyte implantation requires a 2-step procedure (for harvesting and implantation) and is limited by cytotoxicity ...
Tsuyuguchi Y, Nakasa T, Ishikawa M, Miyaki S, Matsushita R, Kanemitsu M, Adachi N.   +6 more
europepmc   +2 more sources

Periodic Mechanical Stress INDUCES Chondrocyte Proliferation and Matrix Synthesis via CaMKII-Mediated Pyk2 Signaling

Cellular Physiology and Biochemistry, 2017
Background/Aims: Periodic mechanical stress can promote chondrocyte proliferation and matrix synthesis to improve the quality of tissue-engineered cartilage. Although the integrin β1–ERK1/2 signal cascade has been implicated in periodic mechanical stress-
Wenwei Liang, Zeng Li, Zhen Wang, Jinchun Zhou, Huanghe Song, Shun Xu, Weiding Cui, Qing Wang, Zhefeng Chen, Feng Liu, Weimin Fan   +10 more
doaj   +2 more sources

G-protein-coupled estrogen receptor-1 facilitates chondrocyte proliferation in pubertal epiphyseal growth plate via PTHrP/Ihh regulation [PDF]

Bone & Joint Research
Aims: Oestrogen drives long-bone development through various oestrogen receptors. G-protein-coupled oestrogen receptor-1 (GPER-1), a membrane oestrogen receptor, mediates longitudinal bone growth during early puberty; however, the underlying mechanisms ...
Ya-Shuan Chou, Sung-Yen Lin, Shu-Chun Chuang, Pei-Yin Shih, Chung-Hwan Chen, Mei-Ling Ho, Je-Ken Chang   +6 more
doaj   +2 more sources

Bushen Tongluowan promotes chondrocyte proliferation through multi-gene regulation

Pharmacological Research - Modern Chinese Medicine, 2022
Traditional Chinese orthopedics has a long history and excellent clinical effects in the treatment of osteoarthritis (OA). Bushen Tongluowan (BSTLW) is a representative prescription based on ''kidney governing bones'' theory in Traditional Chinese ...
Lu Bocheng, Zhou Zhenwei, Zhang Pengcheng, Huang Jianjun, Li Qingmiao, Zhao Xiaolin, Qu Tingli, Zheng Qian   +7 more
doaj   +2 more sources

Glucosamine promotes chondrocyte proliferation via the Wnt/β‑catenin signaling pathway. [PDF]

Int J Mol Med, 2018
The present study investigated the mechanism underlying the effects of glucosamine (GlcN) on the proliferation of chondrocytes isolated from the knee cartilage of Sprague-Dawley rats.
Ma Y, Zheng W, Chen H, Shao X, Lin P, Liu X, Li X, Ye H.   +7 more
europepmc   +2 more sources

Suv39h1 promotes facet joint chondrocyte proliferation by targeting miR-15a/Bcl2 in idiopathic scoliosis patients. [PDF]

Clin Epigenetics, 2019
Idiopathic scoliosis (IS) is a complex disease with an unclear etiology, and the worldwide prevalence is approximately 2–3%. As an important link between environmental factors and phenotypic differences, epigenetic changes, such as lncRNA, miRNA, and DNA
Li J, Yang G, Liu S, Wang L, Liang Z, Zhang H.   +5 more
europepmc   +2 more sources

A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth

Disease Models & Mechanisms, 2013
SUMMARY Disease mechanisms leading to different forms of chondrodysplasia include extracellular matrix (ECM) alterations and intracellular stress resulting in abnormal changes to chondrocyte proliferation and survival.
Benedetta Gualeni, M. Helen Rajpar, Aaron Kellogg, Peter A. Bell, Peter Arvan, Raymond P. Boot-Handford, Michael D. Briggs   +6 more
doaj   +2 more sources

Guzhi Zengsheng Zhitongwan, a Traditional Chinese Medicinal Formulation, Stimulates Chondrocyte Proliferation through Control of Multiple Genes Involved in Chondrocyte Proliferation and Differentiation. [PDF]

Evid Based Complement Alternat Med, 2018
Chinese materia medica (CMM) are essential components of traditional Chinese medicine, and Chinese medicinal formulas consisting of 2 or more types of CMM are widely used.
Yao B, Lu B, Gao H, Zhang M, Leng X, Zhao D.   +5 more
europepmc   +2 more sources

TGF-β1 regulates chondrocyte proliferation and extracellular matrix synthesis via circPhf21a-Vegfa axis in osteoarthritis. [PDF]

Cell Commun Signal, 2022
Lin S, Li H, Wu B, Shang J, Jiang N, Peng R, Xing B, Xu X, Lu H.   +8 more
europepmc   +3 more sources

LncRNA Malat-1 From MSCs-Derived Extracellular Vesicles Suppresses Inflammation and Cartilage Degradation in Osteoarthritis

Frontiers in Bioengineering and Biotechnology, 2021
Purpose: Extracellular Vesicles (EVs) derived from hMSCs, have the potential to alleviate cartilage damage and inflammation. We aimed to explore the effects of EVs derived from lncRNA malat‐1-overexpressing human mesenchymal stem cells (hMSCs) on ...
Chongzhi Pan, Chongzhi Pan, Chongzhi Pan, Wenzhou Huang, Wenzhou Huang, Wenzhou Huang, Qi Chen, Qi Chen, Qi Chen, Jiu Xu, Guoyu Yao, Bin Li, Bin Li, Bin Li, Bin Li, Tianlong Wu, Tianlong Wu, Tianlong Wu, Changchang Yin, Xigao Cheng, Xigao Cheng, Xigao Cheng, Xigao Cheng   +22 more
doaj   +1 more source