Results 21 to 30 of about 48,883 (320)

Effect of micro-strain stress on in vitro proliferation and functional expression of human osteoarthritic chondrocytes

Journal of Orthopaedic Surgery and Research, 2022
Background This study aimed to analyze the in vitro effect of micro-strain stress on the proliferation and functional marker expression in chondrocytes isolated from human osteoarthritis cartilage samples.
Bin Zhao, Jianxiong Ma, Jinquan He, Xinlong Ma   +3 more
doaj   +1 more source

The Benefit of Minced Cartilage Over Isolated Chondrocytes in Atelocollagen Gel on Chondrocyte Proliferation and Migration. [PDF]

Cartilage, 2021
Objective Autologous chondrocyte implantation is a necessary procedure for the repair of articular cartilage defects; however, isolated chondrocyte implantation requires a 2-step procedure (for harvesting and implantation) and is limited by cytotoxicity due to enzymatic digestion.
Tsuyuguchi Y, Nakasa T, Ishikawa M, Miyaki S, Matsushita R, Kanemitsu M, Adachi N.   +6 more
europepmc   +5 more sources

Mesenchymal stem cell-derived extracellular vesicles prevent the development of osteoarthritis via the circHIPK3/miR-124-3p/MYH9 axis

Journal of Nanobiotechnology, 2021
Background Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration.
Shenglong Li, Jie Liu, Siyu Liu, Weijie Jiao, Xiaohong Wang   +4 more
doaj   +1 more source

Periodic mechanical stress activates MEK1/2-ERK1/2 mitogenic signals in rat chondrocytes through Src and PLCγ1

Brazilian Journal of Medical and Biological Research, 2011
The mitogenic effects of periodic mechanical stress on chondrocytes have been studied extensively but the mechanisms whereby chondrocytes sense and respond to periodic mechanical stress remain a matter of debate.
Kewei Ren, Yimin Ma, Yumin Huang, Wenwei Liang, Feng Liu, Qing Wang, Weiding Cui, Zhengyu Liu, Guoyong Yin, Weimin Fan   +9 more
doaj   +1 more source

SFMBT2 positively regulates SOX9 and chondrocyte proliferation

International Journal of Molecular Medicine, 2018
SRY‑box 9 (SOX9) is the master regulator of the chondrocyte phenotype, which is essential for differentiating chondrogenic mesenchymal condensations into chondrocytes, and is involved in regulating every stage of chondrocyte differentiation. SOX9 deletion in chondrocytes at the late stages of cartilage development results in decreased chondrocyte ...
Saddam Hussain, Mengyao Sun, Yuanxu Guo, Nosheen Mushtaq, Yitong Zhao, Ying Yuan, Nazim Hussain, Ezra Kombo Osoro, Abubakar Suleiman, A. S. Muhammad, Fujun Zhang, Yan Han, Jian Sun, Shemin Lu   +13 more
openalex   +4 more sources

Syndecan-3 Is a Selective Regulator of Chondrocyte Proliferation [PDF]

Journal of Biological Chemistry, 2002
Chondrocyte proliferation is important for skeletal development and growth, but the mechanisms regulating it are not completely clear. Previously, we showed that syndecan-3, a cell surface heparan sulfate proteoglycan, is expressed by proliferating chondrocytes in vivo and that proliferation of cultured chondrocytes in vitro is sensitive to ...
Mufei Liu, Ellis E. Golub, Maurizio Pacifici, Thorsten Kirsch, Eiki Koyama   +4 more
openaire   +3 more sources

In vitro and in vivo validation of human and goat chondrocyte labeling by green fluorescent protein lentivirus transduction [PDF]

, 2010
We investigated whether human articular chondrocytes can be labeled efficiently and for long-term with a green fluorescent protein (GFP) lentivirus and whether the viral transduction would influence cell proliferation and tissue-forming capacity.
Acharya, Chitrangada, Barbero, Andrea, Candrian, Christian, Gianni-Barrera, Roberto, Jaquiery, Claude, Juelke, Henriette, Mainil-Varlet, Pierre, Martin, Ivan, Miot, Sylvie, Pelttari, Karoliina   +9 more
core   +1 more source

Loss of the Mammalian DREAM Complex Deregulates Chondrocyte Proliferation [PDF]

Molecular and Cellular Biology, 2014
Mammalian DREAM is a conserved protein complex that functions in cellular quiescence. DREAM contains an E2F, a retinoblastoma (RB)-family protein, and the MuvB core (LIN9, LIN37, LIN52, LIN54, and RBBP4). In mammals, MuvB can alternatively bind to BMYB to form a complex that promotes mitotic gene expression.
Forristal, Chantal, Henley, Shauna A., MacDonald, James I., Bush, Jason R., Ort, Carley, Passos, Daniel T., Talluri, Srikanth, Ishak, Charles A., Thwaites, Michael J., Norley, Chris J., Litovchick, Larisa, DeCaprio, James A., DiMattia, Gabriel, Holdsworth, David W., Beier, Frank, Dick, Frederick A.   +15 more
openaire   +4 more sources

Growth factors for clinical-scale expansion of human articular chondrocytes : Relevance for automated bioreactor systems [PDF]

, 2007
The expansion of chondrocytes in automated bioreactors for clinical use requires that a relevant number of cells be generated, starting from variable initial seeding densities in one passage and using autologous serum.
Andrea Barbero, Cherubino P., Christian Candrian, Christina-Priska Sie, Eloit M, Gobbi A., Ivan Martin, Michael Heberer, Roberto Tommasini, Rupert Hagg, Silvia-Elena Francioli, Watt F.M, Wessman S.J.   +12 more
core   +1 more source

Hybrid bioprinting of chondrogenically induced human mesenchymal stem cell spheroids [PDF]

, 2020
To date, the treatment of articular cartilage lesions remains challenging. A promising strategy for the development of new regenerative therapies is hybrid bioprinting, combining the principles of developmental biology, biomaterial science, and 3D ...
Asadian, Mahtab, De Geyter, Nathalie, De Moor, Lise, Declercq, Heidi, Dubruel, Peter, Fernandez, Sélina, Tytgat, Liesbeth, Van Vlierberghe, Sandra, Vercruysse, Chris   +8 more
core   +2 more sources