Results 321 to 330 of about 214,417 (382)

The Use of miRNA Panel as a Growth Plate Marker of Short‐Term Response to GH

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction Recombinant human growth hormone (GH) therapy shows variable growth responses in patients with growth hormone deficiency (GHD), highlighting the need for reliable biomarkers to predict individual sensitivity. Objective This study investigated circulating microRNAs (miRNAs) involved in growth plate regulation during GH therapy in ...
Caroline Rosa Pellicciari, Thayna Rosa Bispo, Itatiana Ferreira Rodart, Leandra Steinmetz, Adriana Aparecida Siviero Miachon, Angela Maria Spinola e Castro, Durval Damiani, Cristiane Kochi, Carlos Alberto Longui   +8 more
wiley   +1 more source

MiR-103-3p regulates chondrocyte autophagy, apoptosis, and ECM degradation through the PI3K/Akt/mTOR pathway by targeting CPEB3. [PDF]

J Orthop Surg Res
Li J, Sun F, Zhang Y, Pan X, Li B, Zhang G, Zhou Q.   +6 more
europepmc   +1 more source

Biallelic FGF4 Variants Linked to Thoracic Dystrophy and Respiratory Insufficiency

Clinical Genetics, EarlyView.
We report three people from two unrelated families with a clinical diagnosis of thoracic dystrophy characterized by short or missing ribs, narrow chest, and respiratory insufficiency. Affected people each have rare, biallelic, predicted deleterious missense substitutions in FGF4, a gene known to be essential for the formation of the thoracic skeleton ...
Laura M. Watts, Esther Kinning, Donald R. Latner, Marla Johnston, Jessica Patrick‐Esteve, Gregory M. Cooper, Stephen R. F. Twigg, Alistair T. Pagnamenta, Jenny C. Taylor   +8 more
wiley   +1 more source

Correction: S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling. [PDF]

Mol Med
Cai W, Wu A, Lin Z, Cao W, Pathak JL, Jaspers RT, Li R, Li X, Zheng K, Lin Y, Zhou N, Zhang X, Zhu Y, Zhang Q.   +13 more
europepmc   +1 more source

Exploring the Therapeutic Potential of MIR‐140‐3p in Osteoarthritis: Targeting CILP and Ferroptosis for Novel Treatment Strategies

Cell Proliferation, EarlyView.
Global landscape. ABSTRACT Osteoarthritis (OA) is a prevalent and debilitating joint disorder that affects millions of individuals worldwide, severely impairing mobility, independence, and quality of life. Emerging evidence suggests that ferroptosis is a critical factor in OA pathogenesis.
Feng Ma, Lexin Wang, Hao Chi, Xinyi Li, Yaoqin Xu, Kexin Chen, Jingfan Zhou, Runqin Yang, Jie Liu, Ke Xu, Xiaoling Yang   +10 more
wiley   +1 more source

Dexamethasone: a double-edged sword in the treatment of osteoarthritis. [PDF]

Sci Rep
Tarasova K, Arteaga MB, Kidtiwong A, Gueltekin S, Bileck A, Gerner C, Gerner I, Jenner F.   +7 more
europepmc   +1 more source

Intelligent Manufacturing for Osteoarthritis Organoids

Cell Proliferation, EarlyView.
Overall schematic of intelligent manufacturing in osteoarthritis organoids. Broad overview of the article's structure, outlining the progression from fundamental joint anatomy and OA pathogenesis to organoid construction and, ultimately, to intelligent manufacturing and future prospects.
Xukun Lyu, Jian Wang, Jiacan Su
wiley   +1 more source

Nanomaterial-Based Drug Delivery Systems Targeting Functional Cells for Osteoarthritis Treatment: Mechanisms, Challenges and Future Prospects. [PDF]

Int J Nanomedicine
Kong H, He Q, Han J, Zhang XA.
europepmc   +1 more source

Engineering Intervertebral Disc Regeneration: Biomaterials, Cell Sources and Animal Models

Cell Proliferation, EarlyView.
This review highlights the current tissue engineering approaches utilising biomaterials, animal models and cell sources for intervertebral disc regeneration and discusses future opportunities. ABSTRACT Intervertebral disc (IVD) degeneration is an age‐related problem triggering chronic spinal issues, such as low back pain and IVD herniation.
Sidong Yang, Farhad Soheilmoghaddam, Peter Pivonka, Joan Li, Samuel Rudd, Trifanny Yeo, Ji Tu, Yibo Zhu, Justin J. Cooper‐White   +8 more
wiley   +1 more source

Membrane biomimetic nanoenzyme-incorporated hybrid glycyrrhizic acid hydrogel for precise mitochondrial ROS scavenging for osteoarthritis treatment. [PDF]

Mater Today Bio
Fan Y, Niu Z, Yin L, Yao L, Ding S, Tong Y, Wang J, Hong Z, Chen J, Zhang Q, Ji L, Chen J, Xia C, Bi Q.   +13 more
europepmc   +1 more source