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PINK1 overexpression suppresses p38 MAPK/NF‑κB signaling to attenuate chondrocyte senescence in osteoarthritis. [PDF]

Int J Mol Med
Jie L, Zhang Y, Liu J, Fu H, Zhu Z, Huang Z, Shi X, Wang P, Yin S.   +8 more
europepmc   +1 more source

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Cell-Free Osteoarthritis Treatment with Sustained-Release of Chondrocyte-Targeting Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells to Rejuvenate Aging Chondrocytes

ACS Nano, 2023
As chondrocytes from osteoarthritic cartilage usually exhibit aging and senescent characteristics, targeting aging chondrocytes could be a potential therapeutic strategy. In this study, exosomes derived from umbilical cord-derived mesenchymal stem cells (
Xiaolin Cui, Tun Yuan, Yujiang Fan
exaly   +2 more sources

Primary culture and phenotyping of murine chondrocytes

Nature Protocols, 2008
Marjolaine Gosset, Francis Berenbaum
exaly   +2 more sources

Quercetin attenuates oxidative stress‐induced apoptosis via SIRT1/AMPK‐mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model

Journal of Cellular Physiology, 2019
Apoptosis of chondrocytes are the main initiator of osteoarthritis (OA) and can be explained by oxidative stress and endoplasmic reticulum (ER) stress, thus the pharmacological interventions aimed at inhibiting of these pathways may be a promising ...
K. Feng, Zhaoxun Chen, Pengcheng Liu, Shu-hong Zhang, Xiaoqing Wang   +4 more
semanticscholar   +1 more source

Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy

Annals of the New York Academy of Sciences, 2018
Articular chondrocytes are quiescent, fully differentiated cells responsible for the homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine‐tuned balance between anabolic and catabolic functions.
Purva Singh, K. Marcu, M. Goldring, M. Otero   +3 more
semanticscholar   +1 more source

Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels

Cell, 1982
P. Benya, J. D. Shaffer
semanticscholar   +1 more source

A dysfunctional TRPV4–GSK3β pathway prevents osteoarthritic chondrocytes from sensing changes in extracellular matrix viscoelasticity

Nature Biomedical Engineering, 2021
Pranay Agarwal, Hong-Pyo Lee, Piera Smeriglio   +2 more
exaly  

Exosomes derived from mesenchymal stem cells inhibit mitochondrial dysfunction-induced apoptosis of chondrocytes via p38, ERK, and Akt pathways

In Vitro Cellular & Developmental Biology - Animal, 2019
Hui Qi, Danping Liu, D. Xiao, Dachuan Tian, Yongwei Su, Shao-Feng Jin   +5 more
semanticscholar   +1 more source

MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint

Autophagy, 2020
Hongxu Yang, Mian Zhang, Qian Liu
exaly