Results 31 to 40 of about 213,570 (404)

Smad4 regulates growth plate matrix production and chondrocyte polarity. [PDF]

, 2017
Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Alliston, Tamara, Berthet, Ellora, Cantu, Andrea, Laird, Diana J, Whitaker, Amanda T   +4 more
core   +3 more sources

MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint

Autophagy, 2019
A switch from autophagy to apoptosis is implicated in chondrocytes during the osteoarthritis (OA) progression with currently unknown mechanism(s). In this study we utilized a flow fluid shear stress (FFSS) model in cultured chondrocytes and a unilateral ...
Hongxu Yang, Yi Wen, Mian Zhang, Qian Liu, Hongyun Zhang, Jing Zhang, Lei Lu, T. Ye, X. Bai, G. Xiao, Mei‐qing Wang   +10 more
semanticscholar   +1 more source

Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytes [PDF]

, 2007
Objective: To identify an appropriate cell source for the generation of meniscus substitutes, among those which would be available by arthroscopy of injured knee joints.
A. Adesida, A. Marsano, Adams, Ahmed, Al-Taher, AufderHeide, Barbero, Barbero, Burr, C. Chiari-Grisar, Chen, Cox, D.M. Salter, De Bari, De Bari, Dell'Accio, Demarteau, Dickinson, E. Kon, E. Tognana, Fithian, Grigolo, Gronthos, Hidaka, Higuchi, Hollander, Hunziker, I. Martin, Ibarra, Ibarra, Jakob, Jakob, Kambic, Levy, Livak, M. Jakob, Martin, Martinek, Melrose, Mikic, Miyamoto, Mochizuki, Moretti, Nakata, Ochi, Pangborn, Park, Peretti, Peretti, Peterson, Port, Reinholz, Rijk, Rijk, Roberts, S. Nehrer, S.J. Millward-Sadler, Sakaguchi, Sweigart, T. Hardingham, Tay, Valiyaveettil, Verdonk, Walsh, Weinand, Wickham, Yaeger, Yoo, Zellner   +68 more
core   +1 more source

MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis

Cell Cycle, 2018
Background: Exosomes secreted by human mesenchymal stem cells (hMSCs) have been shown to promote cartilage regeneration. This study aimed to explore whether exosomal lncRNA-KLF3-AS1 derived from hMSCs can promote chondrocyte proliferation via miR-206 ...
Yubao Liu, Lupan Lin, Rui Zou, C. Wen, Zhen Wang, Fuqing Lin   +5 more
semanticscholar   +1 more source

Fibroblast Growth Factor 18 Increases the Trophic Effects of Bone Marrow Mesenchymal Stem Cells on Chondrocytes Isolated from Late Stage Osteoarthritic Patients

Stem Cells International, 2014
Coculture of mesenchymal stem cells with chondrocytes increases production of cartilaginous matrix. Chondrocytes isolated from late stage osteoarthritic patients usually lost their phenotype of producing cartilaginous matrix.
Zhenyu Zhang, Yan Wang, Mingchao Li, Jiaping Li, Jian Wu   +4 more
doaj   +1 more source

Human iPSC-derived chondrocytes mimic juvenile chondrocyte function for the dual advantage of increased proliferation and resistance to IL-1β

Stem Cell Research & Therapy, 2017
Background Induced pluripotent stem cells (iPSC) provide an unlimited patient-specific cell source for regenerative medicine. Adult cells have had limited success in cartilage repair, but juvenile chondrocytes (from donors younger than 13 years of age ...
Jieun Lee, Piera Smeriglio, Constance R. Chu, Nidhi Bhutani   +3 more
doaj   +1 more source

Human Developmental Chondrogenesis as a Basis for Engineering Chondrocytes from Pluripotent Stem Cells [PDF]

, 2013
Joint injury and osteoarthritis affect millions of people worldwide, but attempts to generate articular cartilage using adult stem/progenitor cells have been unsuccessful.
Adams, John S., Bluguermann, Carolina, Crooks, Gay M., Evseenko, Denis, Galic, Zoran, Ge, Sundi, Gonzalez, Stephanie, Kyupelyan, Levon, Latour, Brooke, Li, Xinmin, Lyons, Karen M., McAllister, David R., Miriuka, Santiago Gabriel, Nsair, Ali, Petrigliano, Frank A., Shah, Saumya, Van Handel, Ben, Wu, Ling, Zhu, Yuhua   +18 more
core   +1 more source

Aucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model

Drug Design, Development and Therapy, 2019
Objective Chondrocyte apoptosis has also been strongly correlated with the severity of cartilage damage and matrix depletion in an osteoarthritis (OA) joint.
Bo-Wei Wang, Yi Jiang, Zilong Yao, Peisheng Chen, Bin Yu, Sheng-nan Wang   +5 more
semanticscholar   +1 more source

Differences in Cartilage-Forming Capacity of Expanded Human Chondrocytes from Ear and Nose and Their Gene Expression Profiles

Cell Transplantation, 2011
The aim of this study was to evaluate the potential of culture-expanded human auricular and nasoseptal chondrocytes as cell source for regeneration of stable cartilage and to analyze the differences in gene expression profile of expanded chondrocytes ...
Catharine A. Hellingman, Eugène T. P. Verwiel, Inez Slagt, Wendy Koevoet, René M. L. Poublon, Gilbert J. Nolst-Trenité, Robert J. Baatenburg De Jong, Holger Jahr, Gerjo J. V. M. Van Osch   +8 more
doaj   +1 more source

Expressions of local renin-angiotensin system components in chondrocytes

European Journal of Histochemistry, 2014
In 2013, we reported that local renin-angiotensin system (local RAS) components express during the hypertrophic differentiation of chondrocytes and can modulate it, using ATDC5 cell line that involves differentiation from mesenchymal stem cells to ...
I. Tsukamoto, M. Akagi, S. Inoue, K. Yamagishi, S. Mori, S. Asada   +5 more
doaj   +1 more source