Results 31 to 40 of about 171,876 (350)

Osteochondrosis lesions of the lateral trochlear ridge of the distal femur in four ponies [PDF]

, 2011
Lesions of the lateral trochlear ridge (LTR) of the distal femur were investigated in four pony or pony cross horses. The animals were all geldings and were six to 15 months of age.
Henson, F.M.D., Jeffcott, L.B., Platt, D., Voute, L.C.   +3 more
core   +1 more source

The emerging chondrocyte channelome [PDF]

Frontiers in Physiology, 2010
Chondrocytes are the resident cells of articular cartilage and are responsible for synthesizing a range of collagenous and non-collagenous extracellular matrix macromolecules. Whilst chondrocytes exist at low densities in the tissue (1-10% of the total tissue volume in mature cartilage) they are extremely active cells and are capable of responding to a
Barrett-Jolley, R, Lewis, R, Fallman, R, Mobasheri, A   +3 more
openaire   +5 more sources

Optimization of TGF-β1-transduced chondrocytes for cartilage regeneration in a 3D printed knee joint model.

PLoS ONE, 2019
A cell therapy product of transforming growth factor (TGF)-β1-transduced chondrocytes has been commercialized to treat osteoarthritis of the knee via intra-articular injection.
Jiyong Ahn, Seon Ae Kim, Ki Won Kim, Joon Hyuck Oh, Seok Jung Kim   +4 more
doaj   +1 more source

SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury. [PDF]

, 2018
Patients with anterior cruciate ligament (ACL) rupture are two times as likely to develop posttraumatic osteoarthritis (PTOA). Annually, there are ∼900,000 knee injuries in the United States, which account for ∼12% of all osteoarthritis (OA) cases.
Baek, Balemans, Baron, Bouaziz, Chan, Chang, Christiansen, Collette, Collette, Dejour, Glasson, Goldring, Hwang, Itin, Kapoor, Karlsson, Li, Li, Livak, Lockwood, Loeser, Lohmander, Loots, Mabey, Ovcharenko, Ratzlaff, Reppe, Rigoglou, Roudier, Sokolove, Swarnkar, Trapnell, Trapnell, Trapnell, van Dinther, Velasco, Wehmeyer, Zhu   +37 more
core   +2 more sources

High glucose upregulates BMAL1 in chondrocytes from macroscopically normal and osteoarthritic human cartilage but this only results in increased collagen synthesis in chondrocytes from macroscopically normal cartilage regions

Osteoarthritis and Cartilage Open
Objective: Osteoarthritic (OA) chondrocytes exhibit limited capacity for new collagen synthesis. High glucose promotes collagen I and III production by fibroblasts.
Lekha Jain, Jacob T. Munro, Jade Tamatea, Nicola Dalbeth, Raewyn C. Poulsen   +4 more
doaj   +1 more source

ATG5 regulates type Ⅱ collagen expression by modulation of autophagy

陆军军医大学学报, 2023
Objective To explore the regulative effect of autophagy-related protein ATG5 on the expression of type Ⅱ collagen in human chondrocytes through affecting autophagy function.
DENG Lin, XIAN Menglin, YANG Yuyou
doaj   +1 more source

Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes [PDF]

, 2005
Basic calcium phosphate (BCP) crystals, including hydroxyapatite, octacalcium phosphate (OCP) and carbonate-apatite, have been associated with severe osteoarthritis and several degenerative arthropathies.
Ea, Hang-Korng, Lioté, Frédéric, Rey, Christian, Uzan, Benjamin   +3 more
core   +7 more sources

Autophagy plays a protective role in advanced glycation end products- induced apoptosis of chondrocytes via regulation of tumor necrosis factor-α , nuclear factor-κ B and reactive oxygen species

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To study the adverse effects of advanced glycation end products (AGEs) on chondrocytes and the role of autophagy in this process. Methods: Chondrocytes were harvested from the human articular cartilage tissues in surgery.
Zhi-Jiang Sun, Ya-Yi Xia
doaj   +1 more source

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]

, 2013
BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
AC Lin, AK Wann, AK Wann, AM Malone, AR Sartori-Cintra, BL Thoms, BL Thoms, CA Clement, CA Clement, CF Chang, CJ Haycraft, CJ Haycraft, CR Thoma, D Kong, D Zhu, DA Hoey, DM Katschinski, E Verghese, EN Pugacheva, F Oeffner, GJ Pazour, HA Praetorius, J Kim, JB Catterall, JC Kim, JE Bohonowych, JE Lafont, JF Reiter, JH Moyer, JH Ryu, JM Gerdes, JR Marszalek, JT Eggenschwiler, KC Corbit, KC Corbit, L Schneider, M Windheim, MA Lancaster, MF Bijlsma, NV Prodromou, P Jaakkola, PD Taulman, PV Tran, R Rohatgi, RD Thornton, S Abdul-Majeed, S Kim, S Massinen, S Murakami, S Proulx-Bonneau, S Yang, SH Low, SM Nauli, SN Greer, SR McGlashan, SR McGlashan, T Caspary, TY Besschetnova, X Xue, Y Li, YJ Jung   +60 more
core   +1 more source

Effects of cell phenotype and seeding density on the chondrogenic capacity of human osteoarthritic chondrocytes in type I collagen scaffolds

Journal of Orthopaedic Surgery and Research, 2020
Objective Matrix-associated autologous chondrocyte implantation (MACI) achieves good clinical efficacy in young patients with focal cartilage injury; however, phenotypic de-differentiation of chondrocytes cultured in monolayer and the treatment of older ...
Chenxi Cao, Yujun Zhang, Yanqi Ye, Tiezheng Sun   +3 more
doaj   +1 more source