Results 31 to 40 of about 97,024 (315)

The β-catenin/TCF-4 pathway regulates the expression of OPN in human osteoarthritic chondrocytes

Journal of Orthopaedic Surgery and Research, 2020
Background Cartilage destruction is the main characteristic of osteoarthritis (OA), and osteopontin (OPN) is elevated in OA articular cartilage; however, the reason for the increased OPN level is not determined.
Jian Tian, Shu-Guang Gao, Yu-Sheng Li, Chao Cheng, Zhen-Han Deng, Wei Luo, Fang-Jie Zhang   +6 more
doaj   +1 more source

Ozone induces autophagy by activating PPARγ/mTOR in rat chondrocytes treated with IL-1β

Journal of Orthopaedic Surgery and Research, 2022
Background Osteoarthritis (OA) is the main cause of older pain and disability. Intra-articular injections of ozone (O3) commonly have been found to have antioxidative and anti-inflammatory effects to reduce pain and improve function in knee ...
Panpan Sun, Weicheng Xu, Xu Zhao, Cong Zhang, Xiaowen Lin, Moxuan Gong, Zhijian Fu   +6 more
doaj   +1 more source

Decreased Peli1 expression attenuates osteoarthritis by protecting chondrocytes and inhibiting M1-polarization of macrophages

Bone & Joint Research, 2023
Aims: Pellino1 (Peli1) has been reported to regulate various inflammatory diseases. This study aims to explore the role of Peli1 in the occurrence and development of osteoarthritis (OA), so as to find new targets for the treatment of OA.
Haokun Mo, Zhenggang Wang, Zhiyi He, Junlai Wan, Rui Lu, Chenwen Wang, Anmin Chen, Peng Cheng   +7 more
doaj   +1 more source

Mechanisms of chondrocyte apoptosis

Osteoarthritis and Cartilage, 1999
This study addresses the occurrence and significance of chondrocyte apoptosis in the pathogenesis of cartilage destruction. Chondrocyte apoptosis can be induced in vitro by nitric oxide donors, but not by pro-inflammatory cytokines, such as IL-1 or TNF.
Klaus Kühn, Martin Lotz, Sanshiro Hashimoto   +2 more
openaire   +3 more sources

Immunological Response against Allogeneic Chondrocytes Transplanted into Joint Surface Defects in Rats

Cell Transplantation, 1997
Rat chondrocytes isolated from the articular–epiphyseal cartilage complex were transplanted into defects prepared in articular cartilage and subchondral bone. Transplants were taken for examination after 3 and 8 wk.
Anna Hyc, Jacek Malejczyk, Anna Osiecka, Stanislaw Moskalewski   +3 more
doaj   +1 more source

Effects of cell phenotype and seeding density on the chondrogenic capacity of human osteoarthritic chondrocytes in type I collagen scaffolds

Journal of Orthopaedic Surgery and Research, 2020
Objective Matrix-associated autologous chondrocyte implantation (MACI) achieves good clinical efficacy in young patients with focal cartilage injury; however, phenotypic de-differentiation of chondrocytes cultured in monolayer and the treatment of older ...
Chenxi Cao, Yujun Zhang, Yanqi Ye, Tiezheng Sun   +3 more
doaj   +1 more source

Circ0083429 Regulates Osteoarthritis Progression via the Mir-346/SMAD3 Axis

Frontiers in Cell and Developmental Biology, 2021
Osteoarthritis (OA) is a degenerative joint disease. Currently, apart from symptomatic treatment or joint replacement, no other effective treatments for OA exist. The mechanisms underlying OA remain elusive and require further research.
Teng Yao, Teng Yao, Yute Yang, Yute Yang, Ziang Xie, Ziang Xie, Yining Xu, Yizhen Huang, Yizhen Huang, Jun Gao, Jun Gao, Shuying Shen, Shuying Shen, Huali Ye, Yasaman Iranmanesh, Shunwu Fan, Shunwu Fan, Jianjun Ma, Jianjun Ma   +18 more
doaj   +1 more source

Multiscale Strain Transfer in Cartilage

Frontiers in Cell and Developmental Biology, 2022
The transfer of stress and strain signals between the extracellular matrix (ECM) and cells is crucial for biochemical and biomechanical cues that are required for tissue morphogenesis, differentiation, growth, and homeostasis.
Manuela A. Boos, Shireen R. Lamandé, Shireen R. Lamandé, Kathryn S. Stok   +3 more
doaj   +1 more source

Intra-articular low-dose parathyroid hormone (1-34) improves mobility and articular cartilage quality in a preclinical age-related knee osteoarthritis model

Bone & Joint Research, 2021
Aims: Osteoarthritis (OA) is prevalent among the elderly and incurable. Intra-articular parathyroid hormone (PTH) ameliorated OA in papain-induced and anterior cruciate ligament transection-induced OA models; therefore, we hypothesized that PTH improved ...
Chung-Hwan Chen, Lin Kang, Ling-Hua Chang, Tsung-Lin Cheng, Sung-Yen Lin, Shun-Cheng Wu, Yi-Shan Lin, Shu-Chun Chuang, Tien-Ching Lee, Je-Ken Chang, Mei-Ling Ho   +10 more
doaj   +1 more source

Autologous Chondrocyte Implantation [PDF]

JBJS Essential Surgical Techniques, 2016
Autologous chondrocyte implantation (ACI) for the treatment of articular cartilage lesions of the knee joint provides successful and durable long-term outcomes.Obtain standing radiographs and magnetic resonance imaging (MRI) scans to identify all associated abnormalities (background factors).Evaluate the knee joint systematically and harvest cartilage ...
Tom Minas, Tim Bryant, Takahiro Ogura
openaire   +3 more sources