The β-catenin/TCF-4 pathway regulates the expression of OPN in human osteoarthritic chondrocytes
Journal of Orthopaedic Surgery and Research, 2020 Background Cartilage destruction is the main characteristic of osteoarthritis (OA), and osteopontin (OPN) is elevated in OA articular cartilage; however, the reason for the increased OPN level is not determined.
Jian Tian +6 more
doaj +1 more source
Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]
, 2014 SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Chapple, JP, Knight, MM, Thompson, CL
core +2 more sources
Genes & Development, 1999 The mechanisms that control cell proliferation and cell differentiation during morphogenesis of the endochondral skeleton of vertebrates are poorly understood.
B. St.-Jacques +2 more
semanticscholar +1 more source
Journal of Orthopaedic Translation, 2021 Background: Chondrons are composed of chondrocytes and the surrounding pericellular matrix (PCM) and function to enhance chondrocyte-mediated cartilage tissue engineering.
Wangping Duan +9 more
doaj
Growth factors for clinical-scale expansion of human articular chondrocytes : Relevance for automated bioreactor systems [PDF]
, 2007 The expansion of chondrocytes in automated bioreactors for clinical use requires that a relevant number of cells be generated, starting from variable initial seeding densities in one passage and using autologous serum.
Andrea Barbero +12 more
core +1 more source
Asporin expression is highly regulated in human chondrocytes [PDF]
Molecular Medicine, Feinstein Institute for Medical Research,
2010, 17 (7-8), pp.816-23, 2015 A significant association between a polymorphism in the D repeat of the gene encoding asporin and osteoarthritis, the most frequent of articular diseases, has been recently reported. The goal of the present study was to investigate the expression of this new class I small leucine-rich proteoglycan (SLRP) in human articular chondrocytes.
arxiv +1 more source
PLoS ONE, 2019 A cell therapy product of transforming growth factor (TGF)-β1-transduced chondrocytes has been commercialized to treat osteoarthritis of the knee via intra-articular injection.
Jiyong Ahn +4 more
doaj +1 more source
Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta [PDF]
Arthritis Research \& Therapy, 2010, 13 (1), pp.R23.
\Transforming growth factor beta (TGF$\beta$) plays a central role in morphogenesis, growth, and cell differentiation. This cytokine is particularly important in cartilage where it regulates cell proliferation and extracellular matrix synthesis. While the action of TGF$\beta$ on chondrocyte metabolism has been extensively catalogued, the modulation of ...
arxiv +1 more source
Mechanical confinement regulates cartilage matrix formation by chondrocytes
Nature Materials, 2017 Cartilage tissue equivalents formed from hydrogels containing chondrocytes could provide a solution for replacing damaged cartilage. Previous approaches have often utilized elastic hydrogels.
Hong-pyo Lee +4 more
semanticscholar +1 more source
A novel culture system for modulating single cell geometry in 3D [PDF]
, 2015 Dedifferentiation of chondrocytes during in vitro expansion remains an unsolved challenge for repairing serious articular cartilage defects. In this study, a novel culture system was developed to modulate single cell geometry in 3D and investigate its ...
Glidle, Andrew +4 more
core +1 more source