Results 41 to 50 of about 216,956 (381)
Journal of Orthopaedic Translation, 2021 Background: Chondrons are composed of chondrocytes and the surrounding pericellular matrix (PCM) and function to enhance chondrocyte-mediated cartilage tissue engineering.
Wangping Duan +9 more
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Genes & Development, 1999 The mechanisms that control cell proliferation and cell differentiation during morphogenesis of the endochondral skeleton of vertebrates are poorly understood.
B. St.-Jacques +2 more
semanticscholar +1 more source
PLoS ONE, 2019 A cell therapy product of transforming growth factor (TGF)-β1-transduced chondrocytes has been commercialized to treat osteoarthritis of the knee via intra-articular injection.
Jiyong Ahn +4 more
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Metaplasia of Chondrocytes into Osteoblasts
Folia Biologica, 2006 Hypertrophic chondrocytes, commonly considered as terminal cells responsible for apoptotic elimination in endochondral osteogenesis, have the potential to switch their metabolic role and enter osteoblastic differentiation, based on histochemical, immunohistochemical, biochemical and cytological analysis.
Krzysztof H Włodarski +2 more
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In Vivo Chondrocyte Mechanics [PDF]
Biophysical Journal, 2010 Mechanical loading of joints deforms articular cartilage cells, and that these cells provide the signals for maintaining cartilage health. Excessive loading of cartilage and cells leads to cartilage degeneration and osteoarthritis.Recently, we developed a novel in vivo testing system that allows for quantification of the mechano-biology of chondrocytes
Ruth A. Seerattan +3 more
openaire +2 more sources
Mechanical confinement regulates cartilage matrix formation by chondrocytes
Nature Materials, 2017 Cartilage tissue equivalents formed from hydrogels containing chondrocytes could provide a solution for replacing damaged cartilage. Previous approaches have often utilized elastic hydrogels.
Hong-pyo Lee +4 more
semanticscholar +1 more source
SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. [PDF]
PLoS Genetics, 2011 Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, and transition to a non-mitotic hypertrophic state.
Victor Y L Leung +10 more
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The n-acetyl phenylalanine glucosamine derivative attenuates the inflammatory/catabolic environment in a chondrocyte-synoviocyte co-culture system [PDF]
, 2019 Osteoarthritis (OA), the most prevalent degenerative joint disease, still lacks a true disease-modifying therapy. The involvement of the NF-κB pathway and its upstream activating kinases in OA pathogenesis has been recognized for many years.
Borzi, R. M. +7 more
core +1 more source
Cell Transplantation, 1997 Rat chondrocytes isolated from the articular–epiphyseal cartilage complex were transplanted into defects prepared in articular cartilage and subchondral bone. Transplants were taken for examination after 3 and 8 wk.
Anna Hyc +3 more
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Asian Pacific Journal of Tropical Medicine, 2018 Objective: To study the adverse effects of advanced glycation end products (AGEs) on chondrocytes and the role of autophagy in this process. Methods: Chondrocytes were harvested from the human articular cartilage tissues in surgery.
Zhi-Jiang Sun, Ya-Yi Xia
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