Results 51 to 60 of about 216,956 (381)

Ozone induces autophagy by activating PPARγ/mTOR in rat chondrocytes treated with IL-1β

Journal of Orthopaedic Surgery and Research, 2022
Background Osteoarthritis (OA) is the main cause of older pain and disability. Intra-articular injections of ozone (O3) commonly have been found to have antioxidative and anti-inflammatory effects to reduce pain and improve function in knee ...
Panpan Sun, Weicheng Xu, Xu Zhao, Cong Zhang, Xiaowen Lin, Moxuan Gong, Zhijian Fu   +6 more
doaj   +1 more source

Glycolytic enzyme PKM2 regulates cell senescence but not inflammation in the process of osteoarthritis

Acta Biochimica et Biophysica Sinica, 2023
Chondrocyte senescence is an important mechanism underlying osteoarthritis in the senile population and is characterized by reduced expressions of the extracellular matrix proteins. The involvement of glycolysis
Liu Bo, Wang Chenzhong, Weng Ziyu, Yang Yi, Zhao Hong, Zhang Yueqi, Fei Qinming, Shi Yi, Zhang Chi   +8 more
doaj   +1 more source

Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond

International Journal of Molecular Sciences, 2019
Growth plate chondrocytes play central roles in the proper development and growth of endochondral bones. Particularly, a population of chondrocytes in the resting zone expressing parathyroid hormone-related protein (PTHrP) is now recognized as skeletal ...
Shawn A. Hallett, W. Ono, N. Ono
semanticscholar   +1 more source

Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells [PDF]

, 2017
Skeletal complications are common features of neonatal-onset multisystem inflammatory disease (NOMID), a disorder caused by NLRP3-activating mutations. NOMID mice in which NLRP3 is activated globally exhibit several characteristics of the human disease ...
Abu-Amer, Yousef, Alippe, Yael, Civitelli, Roberto, Mbalaviele, Gabriel, Qu, Chao, Schipani, Ernestina, Wang, Chun, Xiao, Jianqiu, Xu, Can-Xin   +8 more
core   +2 more sources

Discerning the spatio-temporal disease patterns of surgically induced OA mouse models [PDF]

, 2019
Osteoarthritis (OA) is the most common cause of disability in ageing societies, with no effective therapies available to date. Two preclinical models are widely used to validate novel OA interventions (MCL-MM and DMM).
Becker, Jessica, Bußmann, Patricia, Ertel, Wolfgang, Haase, Tobias, Jagielski, Michal, Kleist, Max von, Kohl, Benjamin, Meier, Carola, Sunkara, Vikram   +8 more
core   +3 more sources

Mechanisms of chondrocyte apoptosis

Osteoarthritis and Cartilage, 1999
This study addresses the occurrence and significance of chondrocyte apoptosis in the pathogenesis of cartilage destruction. Chondrocyte apoptosis can be induced in vitro by nitric oxide donors, but not by pro-inflammatory cytokines, such as IL-1 or TNF.
Klaus Kühn, Martin Lotz, Sanshiro Hashimoto   +2 more
openaire   +3 more sources

Cadmium Toxicity on Chondrocytes and the Palliative Effects of 1α, 25-Dihydroxy Vitamin D3 in White Leghorns Chicken's Embryo

Frontiers in Veterinary Science, 2021
Cadmium (Cd) can causes osteoporosis and joint swelling. However, the mechanism of Cd toxicity in chondrocytes and how to alleviate Cd poisoning to chondrocytes are still unclear.
Jianhong Gu, Jianhong Gu, Jianhong Gu, Saihui Li, Saihui Li, Guoshuai Wang, Guoshuai Wang, Xueqing Zhang, Xueqing Zhang, Yan Yuan, Yan Yuan, Xuezhong Liu, Xuezhong Liu, Xuezhong Liu, Jianchun Bian, Jianchun Bian, Jianchun Bian, Xishuai Tong, Xishuai Tong, Xishuai Tong, Xishuai Tong, Zongping Liu, Zongping Liu, Zongping Liu, Zongping Liu   +24 more
doaj   +1 more source

Roles of TRPV4 and piezo channels in stretch-evoked Ca2+ response in chondrocytes

Experimental biology and medicine, 2019
Chondrocyte mechanotransduction is not well understood, but recently, it has been proposed that mechanically activated ion channels such as transient receptor potential vanilloid 4 (TRPV4), Piezo1, and Piezo2 are of functional importance in chondrocyte ...
Genlai Du, Li Li, Xinwang Zhang, Jianbin Liu, Jianqing Hao, Jianjun Zhu, Haotian Wu, Weiyi Chen, Quanyou Zhang   +8 more
semanticscholar   +1 more source

A homeostatic function of CXCR2 signalling in articular cartilage [PDF]

, 2014
Funding This work was funded by Arthritis Research UK (grants 17859, 17971, 19654), INNOCHEM EU FP6 (grant LSHB-CT-2005-51867), MRC (MR/K013076/1) and the William Harvey Research FoundationPeer reviewedPublisher ...
Aberdeen, Bertrand, J, Brandolini, L, De Bari, C, Dell'Accio, F, Dompe SPA, Karystinou, A, KU Leuven, Luyten, F P, Muenster, Nalesso, G, Pap, T, Pitsillides, A A, Pitzalis, C, Poulet, B, Queen Mary London, Sherwood, J, UCL   +17 more
core   +2 more sources

Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis

iScience, 2021
Summary: Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA.
Taku Ebata, Mohamad Alaa Terkawi, Masanari Hamasaki, Gen Matsumae, Tomohiro Onodera, Mahmoud Khamis Aly, Shunichi Yokota, Hend Alhasan, Tomohiro Shimizu, Daisuke Takahashi, Kentaro Homan, Ken Kadoya, Norimasa Iwasaki   +12 more
doaj