Results 51 to 60 of about 213,570 (404)
In Vivo Chondrocyte Mechanics [PDF]
Biophysical Journal, 2010 Mechanical loading of joints deforms articular cartilage cells, and that these cells provide the signals for maintaining cartilage health. Excessive loading of cartilage and cells leads to cartilage degeneration and osteoarthritis.Recently, we developed a novel in vivo testing system that allows for quantification of the mechano-biology of chondrocytes
Ruth A. Seerattan +3 more
openaire +2 more sources
Cell Transplantation, 1997 Rat chondrocytes isolated from the articular–epiphyseal cartilage complex were transplanted into defects prepared in articular cartilage and subchondral bone. Transplants were taken for examination after 3 and 8 wk.
Anna Hyc +3 more
doaj +1 more source
SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. [PDF]
PLoS Genetics, 2011 Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, and transition to a non-mitotic hypertrophic state.
Victor Y L Leung +10 more
doaj +1 more source
The n-acetyl phenylalanine glucosamine derivative attenuates the inflammatory/catabolic environment in a chondrocyte-synoviocyte co-culture system [PDF]
, 2019 Osteoarthritis (OA), the most prevalent degenerative joint disease, still lacks a true disease-modifying therapy. The involvement of the NF-κB pathway and its upstream activating kinases in OA pathogenesis has been recognized for many years.
Borzi, R. M. +7 more
core +1 more source
Mechanisms of chondrocyte apoptosis
Osteoarthritis and Cartilage, 1999 This study addresses the occurrence and significance of chondrocyte apoptosis in the pathogenesis of cartilage destruction. Chondrocyte apoptosis can be induced in vitro by nitric oxide donors, but not by pro-inflammatory cytokines, such as IL-1 or TNF.
Klaus Kühn +2 more
openaire +3 more sources
Asian Pacific Journal of Tropical Medicine, 2018 Objective: To study the adverse effects of advanced glycation end products (AGEs) on chondrocytes and the role of autophagy in this process. Methods: Chondrocytes were harvested from the human articular cartilage tissues in surgery.
Zhi-Jiang Sun, Ya-Yi Xia
doaj +1 more source
Ozone induces autophagy by activating PPARγ/mTOR in rat chondrocytes treated with IL-1β
Journal of Orthopaedic Surgery and Research, 2022 Background Osteoarthritis (OA) is the main cause of older pain and disability. Intra-articular injections of ozone (O3) commonly have been found to have antioxidative and anti-inflammatory effects to reduce pain and improve function in knee ...
Panpan Sun +6 more
doaj +1 more source
Acta Biochimica et Biophysica Sinica, 2023 Chondrocyte senescence is an important mechanism underlying osteoarthritis in the senile population and is characterized by reduced expressions of the extracellular matrix proteins. The involvement of glycolysis
Liu Bo +8 more
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Response of human engineered cartilage based on articular or nasal chondrocytes to interleukin-1? and low oxygen [PDF]
, 2011 Previous studies showed that human nasal chondrocytes (HNC) exhibit higher proliferation and chondrogenic capacity as compared to human articular chondrocytes (HAC).
Andrea Barbero +8 more
core +1 more source
Roles of TRPV4 and piezo channels in stretch-evoked Ca2+ response in chondrocytes
Experimental biology and medicine, 2019 Chondrocyte mechanotransduction is not well understood, but recently, it has been proposed that mechanically activated ion channels such as transient receptor potential vanilloid 4 (TRPV4), Piezo1, and Piezo2 are of functional importance in chondrocyte ...
Genlai Du +8 more
semanticscholar +1 more source