Results 1 to 10 of about 48,511 (262)

Endogenous chondroitin extends lifespan by inhibiting VHA-7-mediated tubular lysosome formation [PDF]

Scientific Reports
Chondroitin extends lifespan and healthspan in C. elegans, but the relationship between extracellular chondroitin and intracellular anti-aging mechanisms is unknown.
Yukimasa Shibata, Yuri Tanaka, Shunsuke Mori, Kaito Mitsuzumi, Shion Fujii, Hiroyuki Sasakura, Yuki Morioka, Kenji Sugioka, Kosei Takeuchi, Kiyoji Nishiwaki   +9 more
doaj   +2 more sources

Enzymatic Production of Chondroitin Oligosaccharides and Its Sulfate Derivatives

Frontiers in Bioengineering and Biotechnology, 2022
Chondroitin sulfate (CS) has a wide range of physiological functions and clinical applications. However, the biosynthesis of chondroitin oligosaccharides (o-CHs) and sulfate derivatives with specific length is always challenging.
Weijiao Zhang, Weijiao Zhang, Weijiao Zhang, Ruirui Xu, Ruirui Xu, Xuerong Jin, Xuerong Jin, Yang Wang, Yang Wang, Litao Hu, Litao Hu, Tianmeng Zhang, Tianmeng Zhang, Guocheng Du, Guocheng Du, Zhen Kang, Zhen Kang   +16 more
doaj   +1 more source

Gastroprotective Effects of Oral Glycosaminoglycans with Sodium Alginate in an Indomethacin-Induced Gastric Injury Model in Rats

Veterinary Sciences, 2023
The gastrointestinal (GI) mucosal barrier is often exposed to inflammatory and erosive insults, resulting in gastric lesions. Glycosaminoglycans (GAGs), such as hyaluronic acid (HA), chondroitin sulfate (CS), and N-acetylglucosamine (NAG) have shown ...
Sara Traserra, Héctor Cuerda, Adriana Vallejo, Sergi Segarra, Roger Sabata, Marcel Jimenez   +5 more
doaj   +1 more source

Interaction of Chondroitin and Hyaluronan Glycosaminoglycans with Surfaces of Carboxylated Carbon Nanotubes Studied Using Molecular Dynamics Simulations

Molecules, 2023
Interaction of β-D-glucopyranuronic acid (GlcA), N-acetyl-β-D-glucosamine (GlcNAc), N-acetyl-β-D-galactosamine (GalNAc) and two natural decameric glycosaminoglycans, hyaluronic acid (HA) and Chondroitin (Ch) with carboxylated carbon nanotubes, were ...
Tomasz Panczyk, Wojciech Plazinski, François-Yves Dupradeau, Agnieszka Brzyska, Pawel Wolski   +4 more
doaj   +1 more source

Nutrition and dietary supplements in the prevention of osteoarthritis [PDF]

Arhiv za farmaciju, 2016
Optimally balanced diet in order to body weight control in combination with adequate physical activity has an important role in the prevention of degenerative joint disorders.
Vidović Bojana, Đorđević Brižita
doaj   +1 more source

Novelties in the treatment of osteoarthritis [PDF]

Arhiv za farmaciju, 2016
Goal of osteoarthritis (OA) treatment is to relieve the pain and to reduce the loss of patient's physical functionality. Therapy consists of: nonpharmacological measures, pharmacotherapy and surgery.
Stepanović-Petrović Radica, Tomić Maja   +1 more
doaj   +1 more source

Symptomatic delayed-acting drugs (SYSADOA): new applications

Современная ревматология, 2022
The review systematizes modern data indicating effective pain control and a significant improvement in the functional activity of patients suffering from osteoarthritis (OA) using pharmaceutical substances of chondroitin sulfate (CS) and glucosamine (GA).
A. M. Lila, E. A. Taskina, L. I. Alekseeva, N. G. Kashevarova   +3 more
doaj   +1 more source

Misincorporation of Galactose by Chondroitin Synthase of Escherichia coli K4: From Traces to Synthesis of Chondbiuronan, a Novel Chondroitin-Like Polysaccharide

Biomolecules, 2020
Chondroitin synthase KfoC is a bifunctional enzyme which polymerizes the capsular chondroitin backbone of Escherichia coli K4, composed of repeated β3N-acetylgalactosamine (GalNAc)-β4-glucuronic acid (GlcA) units. Sugar donors UDP-GalNAc and UDP-GlcA are
Mélanie Leroux, Julie Michaud, Eric Bayma, Sylvie Armand, Sophie Drouillard, Bernard Priem   +5 more
doaj   +1 more source

Evaluation of unsulfated biotechnological chondroitin in a knee osteoarthritis mouse model as a potential novel functional ingredient in nutraceuticals and pharmaceuticals

Frontiers in Bioengineering and Biotechnology, 2022
Osteoarthritis is a very disabling disease that can be treated with both non-pharmacological and pharmacological approaches. In the last years, pharmaceutical-grade chondroitin sulfate (CS) and glucosamine emerged as symptomatic slow-acting molecules ...
Donatella Cimini, Serena Boccella, Alberto Alfano, Antonietta Stellavato, Salvatore Paino, Chiara Schiraldi, Francesca Guida, Michela Perrone, Maria Donniacuo, Virginia Tirino, Vincenzo Desiderio, Barbara Rinaldi   +11 more
doaj   +1 more source

The use of dietary supplements supporting functioning of musculoskeletal system in rehabilitation clinic patients

Annales Academiae Medicae Silesiensis, 2022
Introduction Musculoskeletal conditions are often characterized by pain, as well as limited physical function. To alleviate pain accompanying musculoskeletal diseases, non-steroidal anti-inflammatory drugs (NSAIDs) and/or paracetamol are used.
Paulina Pluta, Weronika Osmala-Kurpiewska, Agata Piekut   +2 more
doaj   +1 more source