Results 221 to 230 of about 89,429 (244)
Some of the next articles are maybe not open access.
Macromolecular assembly of chondroitin
Biochemical and Biophysical Research Communications, 1972Abstract A microsomal preparation from chick embryo epiphyseal cartilage has been used to study the assembly of the heteropolysaccharide, chondroitin. Endogenous chondroitin sulfate in the microsomal preparation was found to act as a primer for the addition of relatively short non-sulfated polysaccharide chains to form large molecules with a large ...
Jeremiah E. Silbert +2 more
openaire +3 more sources
[34] Microsomal sulfation of proteochondroitin, chondroitin, and chondroitin oligosaccharides
1989Publisher Summary This chapter focuses on the microsomal sulfation of proteochondroitin, chondroitin, and chondroitin oligosaccharides. Chondroitin sulfate—a polymer of gIucuronic acid (GlcA) and N-acetyl galactosamine (GalNAc)—can be sulfated on either or both the 4 and 6 positions of the GalNAc and on the 2 position of the GlcA. Chondroitin sulfate
Donald E. Humphries +2 more
openaire +3 more sources
2003
In the 1950s, in vitro studies of glucosamine demonstrated its potential to increase fibroblast production of collagen and mucopolysaccharides. These findings led to studies of glucosamine for the treatment of osteoarthritis (OA) in humans, first with an injectable product, and then with oral supplementation (McCarty, 1994).
Timothy S. Tracy, Melanie Johns Cupp
openaire +2 more sources
In the 1950s, in vitro studies of glucosamine demonstrated its potential to increase fibroblast production of collagen and mucopolysaccharides. These findings led to studies of glucosamine for the treatment of osteoarthritis (OA) in humans, first with an injectable product, and then with oral supplementation (McCarty, 1994).
Timothy S. Tracy, Melanie Johns Cupp
openaire +2 more sources
Journal of Molecular Structure: THEOCHEM, 2004
Abstract Molecular modeling of glycosaminoglycans, hyaluronan, chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate and keratan sulfate is presented. Semiempirical quantum mechanical calculations, PM3 method, have been used to locate the minimal energy regions in the conformational space around the β 1→3 and β 1→4 glycosidic linkages. The global
Tereza Varnali +3 more
openaire +2 more sources
Abstract Molecular modeling of glycosaminoglycans, hyaluronan, chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate and keratan sulfate is presented. Semiempirical quantum mechanical calculations, PM3 method, have been used to locate the minimal energy regions in the conformational space around the β 1→3 and β 1→4 glycosidic linkages. The global
Tereza Varnali +3 more
openaire +2 more sources
The biosynthesis of chondroitin sulfate
Archives of Biochemistry and Biophysics, 1966Abstract A particulate enzyme preparation from embryonic chick cartilage catalyzes incorporation of radioactivity from UDP-GalNAc- 3 H or UDP-Glc-UA- 14 C into chondroitin sulfate. In the absence of added oligosaccharide acceptor, incorporation of radioactivity from either nucleotide required the presence of the alternate unlabeled nucleotide ...
Alvin Telser +2 more
openaire +3 more sources
Structure of Chondroitin Sulfate
2006Publisher Summary This chapter presents the up‐to‐date information on the structure of chondroitin sulfate (CS) and dermatan sulfate (DS). CS is an anionic linear polysaccharide, which is synthesized as part of proteoglycan (PG) molecules in vertebrates and invertebrates.
Nikos K. Karamanos, Fotini N. Lamari
openaire +3 more sources
The Journal of Biochemistry, 1979
By heating the pyridinium salts of chondroitin 4- and 6-sulfates in dimethyl sulfoxide containing 10% of water or methanol at 80 degrees C for 1--5 h, several chondroitin preparations with sulfur contents of 0.02--1.05% were prepared in 83--96% yields, respectively.
Tsugumi Tokuyasu +2 more
openaire +3 more sources
By heating the pyridinium salts of chondroitin 4- and 6-sulfates in dimethyl sulfoxide containing 10% of water or methanol at 80 degrees C for 1--5 h, several chondroitin preparations with sulfur contents of 0.02--1.05% were prepared in 83--96% yields, respectively.
Tsugumi Tokuyasu +2 more
openaire +3 more sources
Chondroitin Product Selection for the Glucosamine/Chondroitin Arthritis Intervention Trial
Journal of the American Pharmacists Association, 2006To select a high-quality chondroitin dosage form and/or an appropriate source of sodium chondroitin for the National Institutes of Health's Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT).Controlled experimental trials.Laboratory.Not applicable.Commercially available chondroitin products were reviewed, and purified sodium chondroitin from ...
Crystal L. Harris +5 more
openaire +3 more sources
Biosynthesis of Chondroitin Sulphates
Nature, 1959LITTLE information is available regarding the biosynthesis of acid mucopolysaccharides. Knowledge of biosynthetic pathways to the chondroitin sulphates in particular is practically confined to the fact that glucose is utilized for both the hexosamine and uronic acid moieties1 and that 3′—phosphoadenosine 5′—phosphosulphate (PAPS) is involved in ...
openaire +3 more sources
Sequential synthesis of chondroitin oligosaccharides by immobilized chondroitin polymerase mutants
Glycoconjugate Journal, 2008Escherichia coli strain K4 expresses a chondroitin (CH)-polymerizing enzyme (K4CP) that contains two glycosyltransferase active domains. K4CP alternately transfers glucuronic acid (GlcA) and N-acetyl-galactosamine (GalNAc) residues using UDP-GlcA and UDP-GalNAc donors to the nonreducing end of a CH chain acceptor.
Satoshi Shimokata +5 more
openaire +2 more sources