Results 221 to 230 of about 91,886 (318)

Development of a Decellularized Urinary Bladder Matrix and Heparin‐Based Cryogel for Promoting Angiogenesis

open access: yesMacromolecular Bioscience, Volume 25, Issue 8, August 2025.
A dECM‐based cryogel scaffold with sustained VEGF release is developed to promote angiogenesis in ischemic tissues. Fabricated from decellularized porcine urinary bladder matrix and heparin, the scaffold supports VEGF binding and prolonged release. The cryogel demonstrates enhanced angiogenic potential in vitro and in a murine hindlimb ischemia model ...
Dayeon Roo   +7 more
wiley   +1 more source

Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 6, Issue 8, August 2025.
Targeting ECM dysregulation: therapeutic strategies for disease intervention. Dysregulated ECM composition and biomechanics contribute to disease pathogenesis in cancer and fibrotic disorders. Physical modulation: Nanomedicine‐based strategies tune ECM physical properties (e.g., density, stiffness) to enhance drug penetration and therapeutic efficacy ...
Tian Zhao   +11 more
wiley   +1 more source

Osteoarthritis: Mechanisms and Therapeutic Advances

open access: yesMedComm, Volume 6, Issue 8, August 2025.
A schematic illustration of the pathogenesis and emerging therapeutic strategies for OA, including: risk factors and molecular mechanisms of OA, joint changes between healthy and OA conditions, and current emerging therapeutic approaches for OA. Abbreviations: IA: intra‐articular injection; EVs: extracellular vesicles. ABSTRACT Osteoarthritis (OA) is a
Wei Liu   +3 more
wiley   +1 more source

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