Results 21 to 30 of about 93,694 (356)

Chondroitin Sulfate Protects the Liver in an Experimental Model of Extra-Hepatic Cholestasis Induced by Common Bile Duct Ligation

Molecules, 2022
During liver fibrogenesis, there is an imbalance between regeneration and wound healing. The current treatment is the withdrawal of the causing agent; thus, investigation of new and effective treatments is important.
Pedro L. R. Guedes, Carolina P. F. Carvalho, Adriana A. F. Carbonel, Manuel J. Simões, Marcelo Y. Icimoto, Jair A. K. Aguiar, Maria Kouyoumdjian, Marcos L. Gazarini, Marcia R. Nagaoka   +8 more
doaj   +1 more source

Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor [PDF]

Biochemical Journal, 2007
Previously, we have demonstrated that co-expression of ChSy-1 (chondroitin synthase-1), with ChPF (chondroitin-polymerizing factor) resulted in a marked augmentation of glycosyltransferase activities and the expression of the chondroitin polymerase activity of ChSy-1.
Kazuyuki Sugahara, Tomomi Izumikawa, Yuka Okuura, Hiroshi Kitagawa, Toru Uyama   +4 more
openaire   +3 more sources

The use of dietary supplements supporting functioning of musculoskeletal system in rehabilitation clinic patients

Annales Academiae Medicae Silesiensis, 2022
Introduction Musculoskeletal conditions are often characterized by pain, as well as limited physical function. To alleviate pain accompanying musculoskeletal diseases, non-steroidal anti-inflammatory drugs (NSAIDs) and/or paracetamol are used.
Paulina Pluta, Weronika Osmala-Kurpiewska, Agata Piekut   +2 more
doaj   +1 more source

Misincorporation of Galactose by Chondroitin Synthase of Escherichia coli K4: From Traces to Synthesis of Chondbiuronan, a Novel Chondroitin-Like Polysaccharide

Biomolecules, 2020
Chondroitin synthase KfoC is a bifunctional enzyme which polymerizes the capsular chondroitin backbone of Escherichia coli K4, composed of repeated β3N-acetylgalactosamine (GalNAc)-β4-glucuronic acid (GlcA) units. Sugar donors UDP-GalNAc and UDP-GlcA are
Mélanie Leroux, Julie Michaud, Eric Bayma, Sylvie Armand, Sophie Drouillard, Bernard Priem   +5 more
doaj   +1 more source

Evaluation of unsulfated biotechnological chondroitin in a knee osteoarthritis mouse model as a potential novel functional ingredient in nutraceuticals and pharmaceuticals

Frontiers in Bioengineering and Biotechnology, 2022
Osteoarthritis is a very disabling disease that can be treated with both non-pharmacological and pharmacological approaches. In the last years, pharmaceutical-grade chondroitin sulfate (CS) and glucosamine emerged as symptomatic slow-acting molecules ...
Donatella Cimini, Serena Boccella, Alberto Alfano, Antonietta Stellavato, Salvatore Paino, Chiara Schiraldi, Francesca Guida, Michela Perrone, Maria Donniacuo, Virginia Tirino, Vincenzo Desiderio, Barbara Rinaldi   +11 more
doaj   +1 more source

Molecular Cloning of a Chondroitin Polymerizing Factor That Cooperates with Chondroitin Synthase for Chondroitin Polymerization [PDF]

Journal of Biological Chemistry, 2003
We recently cloned human chondroitin synthase (ChSy) exhibiting the glucuronyltransferase-II (GlcATII) and N-acetylgalactosaminyltransferase-II (GalNAcTII) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate, but chondroitin polymerization was not demonstrated in vitro using the recombinant ChSy. We report
Hiroshi Kitagawa, Kazuyuki Sugahara, Toru Uyama, Tomomi Izumikawa   +3 more
openaire   +3 more sources

Symptomatic delayed-acting drugs (SYSADOA): new applications

Современная ревматология, 2022
The review systematizes modern data indicating effective pain control and a significant improvement in the functional activity of patients suffering from osteoarthritis (OA) using pharmaceutical substances of chondroitin sulfate (CS) and glucosamine (GA).
A. M. Lila, E. A. Taskina, L. I. Alekseeva, N. G. Kashevarova   +3 more
doaj   +1 more source

Identification of Chondroitin Sulfate Glucuronyltransferase as Chondroitin Synthase-3 Involved in Chondroitin Polymerization [PDF]

Journal of Biological Chemistry, 2008
Recently, we demonstrated that chondroitin polymerization is achieved by any two combinations of human chondroitin synthase-1 (ChSy-1), ChSy-2 (chondroitin sulfate synthase 3, CSS3), and chondroitin-polymerizing factor (ChPF). Although an additional ChSy family member, called chondroitin sulfate glucuronyltransferase (CSGlcA-T), has been identified ...
Shoko Shiozawa, Kazuyuki Sugahara, Hiroshi Kitagawa, Toshiyasu Koike, Jun-ichi Tamura, Tomomi Izumikawa   +5 more
openaire   +3 more sources

Dietary supplementation with glycosaminoglycans reduces locomotor problems in broiler chickens

Poultry Science, 2020
This study aimed to assess the influence of glycosaminoglycan (chondroitin and glucosamine sulfates) supplementation in the diet on the performance and incidence of locomotor problems in broiler chickens. A completely randomized design was carried out in
Julyana M.S. Martins, Lindolfo D. dos Santos Neto, Raiana A. Noleto-Mendonça, Genilson B. de Carvalho, Sarah Sgavioli, Fabyola Barros de Carvalho, Nadja S.M. Leandro, Marcos B. Café   +7 more
doaj   +1 more source

The optimal way to fill the deficiency of essential substances for the well-being of the joints

Медицинский совет, 2022
The article presents basic information about the role and structure of cartilage tissue and its components, the impact of an imbalance in the structure of nutrition on the well-being of the joints, evidence of the symptomatic and structural-modifying ...
I. S. Dydykina, P. S. Kovalenko, A. A. Aboleshina, A. A. Kovalenko   +3 more
doaj   +1 more source