Chondroitin sulfate proteoglycans from salmon nasal cartilage inhibit angiogenesis [PDF]
Biochemistry and Biophysics Reports, 2017 Because cartilage lacks nerves, blood vessels, and lymphatic vessels, it is thought to contain factors that inhibit the growth and development of those tissues.
Takashi Kobayashi +3 more
doaj +4 more sources
Proteoglycans and neuronal migration in the cerebral cortex during development and disease [PDF]
Frontiers in Neuroscience, 2015 Chondroitin sulfate proteoglycans and heparan sulfate proteoglycans are major constituents of the extracellular matrix and the cell surface in the brain. Proteoglycans bind with many proteins including growth factors, chemokines, axon guidance molecules,
Nobuaki eMaeda
doaj +3 more sources
Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury [PDF]
Nature Communications, 2022 Inflammation resolution failure is a pathological hallmark of spinal cord injury. Here, the authors show in rodents that chondroitin sulfate proteoglycans contribute to failed resolution by preventing immune cells at the injury core from converting to a ...
Isaac Francos-Quijorna +9 more
doaj +2 more sources
Roles of Chondroitin Sulfate Proteoglycans as Regulators of Skeletal Development [PDF]
Frontiers in Cell and Developmental Biology, 2022 The extracellular matrix (ECM) is critically important for most cellular processes including differentiation, morphogenesis, growth, survival and regeneration.
Nancy B. Schwartz +2 more
doaj +2 more sources
Neural Regeneration Research, 2021 Cell transplantation is a potential treatment for spinal cord injury. Olfactory ensheathing cells (OECs) play an active role in the repair of spinal cord injury as a result of the dual characteristics of astrocytes and Schwann cells.
Guo-Yu Wang +4 more
doaj +2 more sources
Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type [PDF]
Scientific Reports, 2017 Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Elisabet Ihse +5 more
doaj +3 more sources
Spatiotemporal distribution of chondroitin sulfate proteoglycans after optic nerve injury in rodents. [PDF]
Exp Eye Res, 2020 Pearson CS +5 more
europepmc +3 more sources
Pattern of chondroitin sulfate proteoglycan expression after ablation of the sensorimotor cortex of the neonatal and adult rat brain [PDF]
Archives of Biological Sciences, 2008 The central nervous system has a limited capacity for self-repair after damage. However, the neonatal brain has agreater capacity for recovery than the adult brain.
Dacić Sanja +6 more
doaj +3 more sources
Nature Communications, 2016 Chondroitin sulfate proteoglycans (CSPGs) secreted by astrocytes are known to inhibit OPC differentiation and remyelination. Here, the authors identify a novel CSPG synthesis inhibitor and find it can rescue OPC differentiation in vitroand accelerate ...
Michael B Keough +2 more
exaly +2 more sources
Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans
Neural Regeneration Research, 2017 The current dogma in neural regeneration research implies that chondroitin sulfate proteoglycans (CSPGs) inhibit plasticity and regeneration in the adult central nervous system (CNS). We argue that the role of the CSPGs can be reversed from inhibition to
Heikki Rauvala +3 more
doaj +2 more sources