Results 1 to 10 of about 15,622 (209)
Roles of Chondroitin Sulfate Proteoglycans as Regulators of Skeletal Development [PDF]
Frontiers in Cell and Developmental Biology, 2022 The extracellular matrix (ECM) is critically important for most cellular processes including differentiation, morphogenesis, growth, survival and regeneration.
Nancy B. Schwartz +2 more
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Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans
Neural Regeneration Research, 2017 The current dogma in neural regeneration research implies that chondroitin sulfate proteoglycans (CSPGs) inhibit plasticity and regeneration in the adult central nervous system (CNS). We argue that the role of the CSPGs can be reversed from inhibition to
Heikki Rauvala +3 more
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Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury [PDF]
Nature Communications, 2022 Inflammation resolution failure is a pathological hallmark of spinal cord injury. Here, the authors show in rodents that chondroitin sulfate proteoglycans contribute to failed resolution by preventing immune cells at the injury core from converting to a ...
Isaac Francos-Quijorna +9 more
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The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development. [PDF]
J Histochem Cytochem, 2021 The orderly development of the nervous system is characterized by phases of cell proliferation and differentiation, neural migration, axonal outgrowth and synapse formation, and stabilization. Each of these processes is a result of the modulation of genetic programs by extracellular cues.
Mencio CP, Hussein RK, Yu P, Geller HM.
europepmc +5 more sources
Neural Regeneration Research, 2021 Cell transplantation is a potential treatment for spinal cord injury. Olfactory ensheathing cells (OECs) play an active role in the repair of spinal cord injury as a result of the dual characteristics of astrocytes and Schwann cells.
Guo-Yu Wang +4 more
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NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. [PDF]
Nat Neurosci, 2012 In the adult mammalian CNS, chondroitin sulfate proteoglycans (CSPGs) and myelin-associated inhibitors (MAIs) stabilize neuronal structure and restrict compensatory sprouting following injury. The Nogo receptor family members NgR1 and NgR2 bind to MAIs and have been implicated in neuronal inhibition.
Dickendesher TL +13 more
europepmc +6 more sources
Chondroitin sulfate proteoglycans from salmon nasal cartilage inhibit angiogenesis [PDF]
Biochemistry and Biophysics Reports, 2017 Because cartilage lacks nerves, blood vessels, and lymphatic vessels, it is thought to contain factors that inhibit the growth and development of those tissues.
Takashi Kobayashi +3 more
doaj +2 more sources
Inhibition of Heparan Sulfate and Chondroitin Sulfate Proteoglycan Biosynthesis [PDF]
Journal of Biological Chemistry, 2008 Proteoglycans (PGs) are composed of a protein moiety and a complex glycosaminoglycan (GAG) polysaccharide moiety. GAG chains are responsible for various biological activities. GAG chains are covalently attached to serine residues of the core protein. The first step in PG biosynthesis is xylosylation of certain serine residues of the core protein.
Dinesh R. Garud +4 more
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Chondroitin sulfate proteoglycans in the nervous system: inhibitors to repair. [PDF]
Biomed Res Int, 2014 Chondroitin sulfate proteoglycans (CSPGs) are widely expressed in the normal central nervous system, serving as guidance cues during development and modulating synaptic connections in the adult. With injury or disease, an increase in CSPG expression is commonly observed close to lesioned areas. However, these CSPG deposits form a substantial barrier to
Siebert JR +2 more
europepmc +4 more sources
Chondroitin sulfate proteoglycans in neural development and regeneration
Current Opinion in Neurobiology, 2005 Proteoglycans are of two main types, chondroitin sulfate (CSPGs) and heparin sulfate (HSPGs). The CSPGs act mainly as barrier-forming molecules, whereas the HSPGs stabilise the interactions of receptors and ligands. During development CSPGs pattern cell migration, axon growth pathways and axon terminations.
Daniela Carulli +3 more
openalex +5 more sources