Results 181 to 190 of about 8,910 (222)

Fragmentation of the β-Subunit of Human Chorionic Gonadotropin Produced by Choriocarcinoma*

Endocrinology, 1988
When human chorionic gonadotropin (hCG) was subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions with dithiothreitol (DTT), a smaller weight material (CTP'), in addition to the beta-subunit, could be detected by Western blot analysis using antiserum for hCG beta-carboxy-terminal peptide (CTP).
R, Nishimura, K, Ide, T, Utsunomiya, T, Kitajima, Y, Yuki, M, Mochizuki   +5 more
openaire   +2 more sources

Plasma β-subunit human chorionic gonadotropin assay in molar pregnancy and choriocarcinoma

American Journal of Obstetrics and Gynecology, 1977
Serum plasma levels of the beta-subunit of human chorionic gonadotropin (HCG-beta) were measured by radioimmunoassay in 24 women with molar pregnancies and five with choriocarcinoma. In the patients with molar pregnancy, plasma HCG-beta concentrations became undetectable within 8 to 173 days. In the patients with choriocarcinoma, plasma HCG-beta levels
B H, Yuen, W, Cannon, J L, Benedet, D A, Boyes   +3 more
openaire   +2 more sources

Hyperglycosylated human chorionic gonadotropin and human chorionic gonadotropin free beta-subunit: tumor markers and tumor promoters.

The Journal of reproductive medicine, 2008
Human chorionic gonadotropin (hCG) is a heterogeneous glycoprotein hormone comprising an alpha-subunit and beta-subunit that can vary in peptide and carbohydrate structure. After conception, hCG produced by early trophoblast cells acts on luteinizing hormone (LH)/hCG receptor corpus luteum cells to promote progesterone production and establish maternal
Laurence A, Cole, Stephen A, Butler
openaire   +1 more source

Structure of the Human Chorionic Gonadotropin β-Subunit Fragment from Pregnancy Urine*

Endocrinology, 1988
A major portion of the hCG immunoreactivity detectable in pregnancy urine is derived from a fragment of hCG beta. This lacks the COOH-terminal portion of hCG beta, but retains immunoreactivity with most antibodies raised against the beta-subunit of hCG.
S, Birken, E G, Armstrong, M A, Kolks, L A, Cole, G M, Agosto, A, Krichevsky, J L, Vaitukaitis, R E, Canfield   +7 more
openaire   +2 more sources

[Monoclonal antibodies against the beta subunit of human chorionic gonadotropin].

Biulleten' eksperimental'noi biologii i meditsiny, 1989
The aim of investigation was creation of hybridomas, which produce monoclonal antibodies to the beta-subunit of human chorionic gonadotropin (beta-hCG), characterization of monoclonal antibodies, which necessary for hCG immunoassay in biological fluids, as an immunological methods of detection of early stage of pregnancy and choriocarcinoma.
R, Fidler, A V, Sokolov, M Sh, Verbitskiĭ, I P, Papazov   +3 more
openaire   +1 more source

Monoclonal antibodies to human chorionic gonadotropin and its beta-subunit.

Nihon Sanka Fujinka Gakkai zasshi, 1984
Using the technique of somatic cell fusion, monoclonal antibodies to human chorionic gonadotropin (hCG) and its beta-subunit were produced. Spleen cells from immunized mice were fused with the myeloma line NS-1 using 50% polyethylene glycol and cultured in a selection medium.
Y, Furuhashi, H, Mano, S, Hattori, S, Goto, Y, Tomoda   +4 more
openaire   +1 more source

Quantitation of whole molecule human chorionic gonadotropin and free beta-human chorionic gonadotropin subunit in the Abbott IMx analyser.

European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1991
An assay for the quantitation of the serum levels of free and whole molecule-associated beta-subunit of human chorionic gonadotropin on the Abbott IMx analyzer is described. The assay detects human beta-chorionic gonadotropin with a sensitivity of approximately 0.5 IU/l while showing no cross-reactivity with follitropin (1000 IU/l) or thyrotropin (2.0 ...
S D, Figard, J B, Bodner, D M, Babik, D M, Mlyniec, B, Simpson, M, Venetucci, E A, Ogunro   +6 more
openaire   +1 more source

Evidence for free beta-subunit secretion in so-called human chorionic gonadotropin-positive seminoma

Cancer, 1988
In 349 patients with pure seminoma the authors determined human chorionic gonadotropin (HCG) plus the free beta-subunit (HCG-beta) by a polyclonal radioimmunoassay (RIA) and found elevated serum levels in 42 patients (12%). In addition, each HCG and HCG-beta were specifically measured by monoclonal immunoradiometric assays (IRMA) in 19 of these ...
K, Mann, K, Siddle
openaire   +2 more sources

Free human chorionic gonadotropin beta subunit in gonadal and nongonadal neoplasms.

Cancer research, 1992
The diagnostic value of elevated human chorionic gonadotropin (hCG) and its free alpha (hCG alpha) and beta (hCG beta) subunit serum levels as specific tumor markers for nongonadal malignancies is controversial. In the present report, different monoclonal based immunoradiometric assays specific for hCG and its free hCG alpha and hCG beta subunits have ...
I, Marcillac, F, Troalen, J M, Bidart, P, Ghillani, V, Ribrag, B, Escudier, B, Malassagne, J P, Droz, C, Lhommé, P, Rougier   +9 more
openaire   +1 more source

Coexpression of human chorionic gonadotropin beta subunit and its receptor in nontrophoblastic gynecological cancer

International Journal of Gynecological Cancer, 2008
A considerable number of biochemical and physiologic studies evaluate the roles of gonadotropins in carcinogenesis. Latest reports show that human chorionic gonadotropin (hCG), and especially its beta subunit, are secreted by a variety of malignant tumors of different origin. However, the mechanism of hCG action and its role in tumor development is not
A, Jankowska, M, Andrusiewicz, J, Grabowski, E, Nowak-Markwitz, J B, Warchol   +4 more
openaire   +2 more sources