Results 191 to 200 of about 4,284 (223)

Characterization of a Discrete Degradation Product of the Human Chorionic Gonadotropin β-Subunit in Humans

The Journal of Clinical Endocrinology & Metabolism, 1980
We have investigated the different forms of immunoreactive hCGβ excreted in the urine of normal volunteers after iv administration of highly purified hCG β-subunit. Chromatography of urine on Sephadex G-100 revealed two discrete peaks ofhCGβ immunoreactivity as measured with antiserum to hCGβ (SB6).
R E, Wehmann, B C, Nisula
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Expression of α- and β-human chorionic gonadotropin subunits in cultured human cells

In Vitro Cellular & Developmental Biology, 1990
We surveyed several human cell lines for production of alpha- and beta-human chorionic gonadotropin (hCG) under a variety of conditions known to induce gene expression. alpha- and beta-hCG subunits were monitored in culture media by specific radioimmunoassays and were shown to be quite sensitive to serum refeeding and growth state of all cell types ...
S, Goldstein, R A, Jones, J W, Hardin, G D, Braunstein, R J, Shmookler Reis   +4 more
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Detection and Quantitation of the β-Subunit of Human Chorionic Gonadotropin in Serum by Radioimmunoassay

Fertility and Sterility, 1980
Qualitative and quantitative radioimmunoassays (RIA) specific for the beta-subunit of human chorionic gonadotropin (HCG) produced by Wampole Laboratories and Monitor Science Corporation were compared in a study involving the sera from 213 individuals. Qualitative assays from both manufacturers were found to be equivalent in clinical specificity (99.2%).
W L, Boyko, B, Barrett
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Evolution of the genes for the β subunits of human chorionic gonadotropin and luteinizing hormone

Nature, 1984
Nucleotide sequence comparisons of the single gene for the human luteinizing hormone gene beta subunit with two of the seven genes for the human chorionic gonadotropin beta subunit suggest that the beta human chorionic gonadotropin genes have evolved from an ancestral beta luteinizing hormone gene by a series of selected changes with very little ...
K, Talmadge, N C, Vamvakopoulos, J C, Fiddes   +2 more
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A Radioimmunoassay for the Core Fragment of the Human Chorionic Gonadotropinβ-Subunit

The Journal of Clinical Endocrinology & Metabolism, 1988
We developed a RIA for the beta-core fragment of hCG that is excreted in the urine of pregnant women and some patients with cancer. We purified beta-core from crude commercial preparations of hCG (of which beta-core is a major constituent) derived from pregnancy urine and used this purified beta-core material to immunize rabbits.
A H, Akar, R E, Wehmann, D L, Blithe, C, Blacker, B C, Nisula   +4 more
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Monoclonal antibodies to human chorionic gonadotropin and its beta-subunit.

Nihon Sanka Fujinka Gakkai zasshi, 1984
Using the technique of somatic cell fusion, monoclonal antibodies to human chorionic gonadotropin (hCG) and its beta-subunit were produced. Spleen cells from immunized mice were fused with the myeloma line NS-1 using 50% polyethylene glycol and cultured in a selection medium.
Y, Furuhashi, H, Mano, S, Hattori, S, Goto, Y, Tomoda   +4 more
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[Monoclonal antibodies against the beta subunit of human chorionic gonadotropin].

Biulleten' eksperimental'noi biologii i meditsiny, 1989
The aim of investigation was creation of hybridomas, which produce monoclonal antibodies to the beta-subunit of human chorionic gonadotropin (beta-hCG), characterization of monoclonal antibodies, which necessary for hCG immunoassay in biological fluids, as an immunological methods of detection of early stage of pregnancy and choriocarcinoma.
R, Fidler, A V, Sokolov, M Sh, Verbitskiĭ, I P, Papazov   +3 more
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Monoclonal Antibodies Against Immunodeterminants Associated with the Alpha and Beta Subunits of Human Chorionic Gonadotropin

Hybridoma, 1982
Spleen cells of BALB/c mice immunized with human chorionic gonadotropin (HCG), a glycopeptide hormone composed of two nonidentical alpha and beta subunits, were fused with NS-1 mouse myeloma cells. Two hybrid cell lines, cone PC2 and clone PD3 secreting monoclonal antibodies (McAb) to HCG were isolated.
L, Wang, N, Rahamim, N, Harpaz, C S, Hexter, M, Inbar   +4 more
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Quantitation of whole molecule human chorionic gonadotropin and free beta-human chorionic gonadotropin subunit in the Abbott IMx analyser.

European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 1991
An assay for the quantitation of the serum levels of free and whole molecule-associated beta-subunit of human chorionic gonadotropin on the Abbott IMx analyzer is described. The assay detects human beta-chorionic gonadotropin with a sensitivity of approximately 0.5 IU/l while showing no cross-reactivity with follitropin (1000 IU/l) or thyrotropin (2.0 ...
S D, Figard, J B, Bodner, D M, Babik, D M, Mlyniec, B, Simpson, M, Venetucci, E A, Ogunro   +6 more
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Coexpression of human chorionic gonadotropin beta subunit and its receptor in nontrophoblastic gynecological cancer

International Journal of Gynecological Cancer, 2008
A considerable number of biochemical and physiologic studies evaluate the roles of gonadotropins in carcinogenesis. Latest reports show that human chorionic gonadotropin (hCG), and especially its beta subunit, are secreted by a variety of malignant tumors of different origin. However, the mechanism of hCG action and its role in tumor development is not
A, Jankowska, M, Andrusiewicz, J, Grabowski, E, Nowak-Markwitz, J B, Warchol   +4 more
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