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Identification and selective destruction of shared epitopes in human chorionic gonadotropin beta subunit

Journal of Reproductive Immunology, 1996
The feasibility of producing epitope-specific antigens by mutation of the gene is demonstrated, the aim being to eliminate unwanted surface epitopes yet allowing the natural folding of the protein to maintain the desired epitope(s). The model protein is the beta subunit of human chorionic gonadotropin (hCG beta) which previously has been used as an ...
A M, Jackson   +7 more
openaire   +3 more sources

Characterization of a Discrete Degradation Product of the Human Chorionic Gonadotropin β-Subunit in Humans

The Journal of Clinical Endocrinology & Metabolism, 1980
We have investigated the different forms of immunoreactive hCGβ excreted in the urine of normal volunteers after iv administration of highly purified hCG β-subunit. Chromatography of urine on Sephadex G-100 revealed two discrete peaks ofhCGβ immunoreactivity as measured with antiserum to hCGβ (SB6).
R E, Wehmann, B C, Nisula
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SYNTHESIS OF CARBOXYL TERMINAL SEGMENTS OF BETA‐SUBUNIT OF HUMAN CHORIONIC GONADOTROPIN

International Journal of Peptide and Protein Research, 1980
The synthesis in solution of carboxyl terminal peptide segments of the beta‐subunit of human chorionic gonadotropin is described. The protected segments include sequences 119–131, 132–137, and 138–145. The syntheses were based on a standardized liquid‐liquid extraction program for routine purification of intermediates (two‐phase method).
H, Rolli   +3 more
exaly   +3 more sources

Coexpression of human chorionic gonadotropin beta subunit and its receptor in nontrophoblastic gynecological cancer

International Journal of Gynecological Cancer, 2008
A considerable number of biochemical and physiologic studies evaluate the roles of gonadotropins in carcinogenesis. Latest reports show that human chorionic gonadotropin (hCG), and especially its beta subunit, are secreted by a variety of malignant tumors of different origin. However, the mechanism of hCG action and its role in tumor development is not
A, Jankowska   +4 more
openaire   +3 more sources

Human Chorionic Gonadotropin Beta Subunit Genes CGB1 and CGB2 are Transcriptionally Active in Ovarian Cancer

open access: yesInternational Journal of Molecular Sciences, 2013
Human chorionic gonadotropin beta subunit (CGB) is a marker of pregnancy as well as trophoblastic and nontrophoblastic tumors. CGB is encoded by a cluster of six genes, of which type II genes (CGB3/9, 5 and 8) have been shown to be upregulated in ...
Grzegorz Walkowiak   +2 more
exaly   +2 more sources

Human Chorionic Gonadotropin β-Subunit in Human Semen

Archives of Andrology, 1988
The level of human seminal chorionic gonadotropin beta-subunit (hCG beta) was determined by radioimmunoassay (RIA). The mean hCG beta level in 34 normal men was 3.7 +/- 1.6 ng/ml, which was much higher than that in serum. The mean hCG beta level for 20 patients with mild oligozoospermia (20-39 x 10(6) sperm/ml) was 2.5 +/- 0.8 ng/ml, that for 34 ...
S, Saito   +3 more
openaire   +2 more sources

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