Results 91 to 100 of about 259,952 (309)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Chromatin interaction maps reveal genetic regulation for quantitative traits in maize

Nature Communications, 2019
Spatial organization of regulatory elements and its impact on gene expression in plants remain unclear. Here, the authors construct maize chromatin interaction maps using chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) and show ...
Yong Peng, Dan Xiong, Lun Zhao, Weizhi Ouyang, Shuangqi Wang, Jun Sun, Qing Zhang, Pengpeng Guan, Liang Xie, Wenqiang Li, Guoliang Li, Jianbing Yan, Xingwang Li   +12 more
doaj   +1 more source

Cell-free system for assembly of transcriptionally repressed chromatin from Drosophila Embryos [PDF]

, 1992
We descrtbe a cell·free system, derlved (rom preblastoderm DrosophÜIJ embryos. ror tbe efficient assembly of eloned DNA into chromatin. Tbe cbromatin assembly system ulilizes cndogcDous eure histones aod assembly racton aod yields loog arrays of ...
Earl Wu, Becker, Peter B., Wu, Chun-Guey, Peter B. Beckert   +3 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Long-Range Chromatin Interactions in the Kidney [PDF]

Journal of the American Society of Nephrology, 2019
Genome-wide association studies (GWAS) have emerged as one of the most powerful tools to define DNA sequence variants associated with common diseases or phenotypes. Massive phenotyping efforts coupled with inexpensive genotyping arrays have resulted in GWAS data on millions of individuals and ...
Yuting Guan, Hongbo Liu, Katalin Susztak
openaire   +2 more sources

Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway [PDF]

, 2012
Background Protein kinase CK2 is a pleiotropic serine/threonine protein kinase with hundreds of reported substrates, and plays an important role in a number of cellular processes.
Hamelin, R., Hamelin Romain, Marc Moniatte, Amit Sharma, Chêne Arnaud, Doerig Christian, Lopez-Rubio, Jose-Juan, Dayer Guillem, Sharma, Amit, Dorin-Semblat Dominique, Dominique Dorin-Semblat, Doerig, C., Holland, Zoe M., Claes, Aurelie, Scherf, Artur, Guillem Dayer, Moniatte Marc, Sharma, A., Dayer, Guillem, Moniatte, Marc, Eeshita G Dastidar, Moniatte, M., Dorin-Semblat, Dominique, Chene, A., Dastidar, Eeshita, Claes Aurélie, Scherf, A., Aurelie Claes, Artur Scherf, Jose-Juan Lopez-Rubio, Lopez-Rubio Jose-Juan, Romain Hamelin, Claes, A., Sharma Amit, Dastidar Eeshita G, Zoe M Holland, Lopez-Rubio, J-J., Hamelin, Romain, Chene, Arnaud, Dayer, G., Scherf Artur, Dastidar, E.G., Doerig, Christian, Arnaud Chene, Dastidar, Eeshita G., Holland, Z.M., Dorin-Semblat, D., Holland Zoe M, Holland, Zoe, Christian Doerig   +49 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Crenarchaeal chromatin proteins Cren7 and Sul7 compact DNA by inducing rigid bends

, 2012
Archaeal chromatin proteins share molecular and functional similarities with both bacterial and eukaryotic chromatin proteins. These proteins play an important role in functionally organizing the genomic DNA into a compact nucleoid.
White, Malcolm F., Meng, He, van Noort, John, Noort, S.J.T. van, Schiessel, Helmut, Shahapure, Rajesh, Lanzani, G., Meng, H., Dame, Remus Th, Driessen, R.P.C., Shahapure, R., Suresh, G., Driessen, Rosalie P. C., Lanzani, Giovanni, Suresh, Gorle, Schiessel, H., Dame, R.T., Priyakumar, U. Deva, Priyakumar, U.D., White, M.F.   +19 more
core   +1 more source

TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner [PDF]

, 2012
Mammalian telomeres stabilize chromosome ends as a result of their assembly into a peculiar form of chromatin comprising a complex of non-histone proteins named shelterin.
Giraud-Panis, Marie-Josèphe, Marie-Josèphe Giraud-Panis, Giraud-Panis Marie-Josèphe, Giraud-Panis, M.J., Maria Savino (169324), Pinte, Sébastien, Maria Savino, Eric Gilson (139222), Colasanti, Valentina, Bauwens, Serge, Valentina Colasanti (169302), Pusch, Miriam Caroline, Stefano Cacchione, Bauwens Serge, Frédérique Magdinier (169297), Colasanti Valentina, Pinte Sébastien, Magdinier, Frédérique, Miriam Caroline Pusch, Gilson, Eric, Alessandra Galati, Pusch Miriam Caroline, Savino Maria, Ruggero Ricordy (169313), Gilson Eric, Serge Bauwens, M. J. Giraud Panis, Cacchione Stefano, Stefano Cacchione (169328), Magdinier Frédérique, Ruggero Ricordy, Eric Gilson, Frederique Magdinier, Sébastien Pinte (169308), Galati, Alessandra, Cacchione, Stefano, Sebastien Pinte, Marie-Josèphe Giraud-Panis (169317), Galati Alessandra, Savino, Maria, Miriam Caroline Pusch (169321), Valentina Colasanti, Ricordy, Ruggero, Ricordy Ruggero, Alessandra Galati (169293), Serge Bauwens (169304)   +45 more
core   +1 more source