Results 101 to 110 of about 259,952 (309)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Landscape of the Epstein-Barr virus-host chromatin interactome and gene regulation

The EMBO Journal
The three-dimensional (3D) chromatin structure of Epstein–Barr virus (EBV) within host cells and the underlying mechanisms of chromatin interaction and gene regulation, particularly those involving EBV’s noncoding RNAs (ncRNAs), have remained ...
Simon Zhongyuan Tian, Yang Yang, Duo Ning, Ting Yu, Tong Gao, Yuqing Deng, Ke Fang, Yewen Xu, Kai Jing, Guangyu Huang, Gengzhan Chen, Pengfei Yin, Yiming Li, Fuxing Zeng, Ruilin Tian, Meizhen Zheng   +15 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc [PDF]

, 2009
HP1 is a major component of chromatin and regulates gene expression through its binding to methylated histone H3. Most eukaryotes express at least three isoforms of HP1 with similar domain architecture.
Eskeland, Ragnhild, RAFFA, GRAZIA DANIELA, Eskeland Ragnhild, Abel, Jochen, Jochen Abel, Raffa Grazia D., Raffa, Grazia D, Ragnhild Eskeland, Abel Jochen, Kremmer Elisabeth, Abel, J., Imhof Axel, Raffa, G.D., Ragnhild Eskel, Imhof, Axel, Eskeland, R., Grazia D. Raffa, Kremmer, E., Imhof, A., Kremmer, Elisabeth, Axel Imhof, Grazia D Raffa, Elisabeth Kremmer   +22 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation

eLife, 2017
The Suv39h1 and Suv39h2 histone lysine methyltransferases are hallmark enzymes at mammalian heterochromatin. We show here that the mouse Suv39h2 enzyme differs from Suv39h1 by containing an N-terminal basic domain that facilitates retention at mitotic ...
Oscar Velazquez Camacho, Carmen Galan, Kalina Swist-Rosowska, Reagan Ching, Michael Gamalinda, Fethullah Karabiber, Inti De La Rosa-Velazquez, Bettina Engist, Birgit Koschorz, Nicholas Shukeir, Megumi Onishi-Seebacher, Suzanne van de Nobelen, Thomas Jenuwein   +12 more
doaj   +1 more source

Stress-Induced PARP Activation Mediates Recruitment of Drosophila Mi-2 to Promote Heat Shock Gene Expression [PDF]

, 2011
Eukaryotic cells respond to genomic and environmental stresses, such as DNA damage and heat shock (HS), with the synthesis of poly-ADP-ribose] (PAR) at specific chromatin regions, such as DNA breaks or HS genes, by PAR polymerases (PARP). Little is known
Renate Renkawitz-Pohl, Hassler Markus, Murawska, Magdalena, Ladurner Andreas, Brehm Alexander, Andreas Ladurner, Renkawitz-Pohl, Renate, Brehm, Alexander, Ladurner, Andreas, Magdalena Murawska, Murawska Magdalena, Markus Hassler, Hassler, Markus, Alexander Brehm, Renkawitz-Pohl Renate   +14 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Interaction of gamma-herpesvirus genome maintenance proteins with cellular chromatin.

PLoS ONE, 2013
The capacity of gamma-herpesviruses to establish lifelong infections is dependent on the expression of genome maintenance proteins (GMPs) that tether the viral episomes to cellular chromatin and allow their persistence in latently infected proliferating ...
Nouman Mughal, Giuseppe Coppotelli, Simone Callegari, Stefano Gastaldello, Maria G Masucci   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source