Results 111 to 120 of about 259,952 (309)

Influence of DNA methylation and chromatin accessibility on regulation of gene expression during Trichomonas vaginalis-host cell interaction

mBio
Trichomonas vaginalis is a common sexually transmitted parasite that colonizes the human urogenital tract, causing infections that range from asymptomatic to highly inflammatory.
Daniela Muñoz, Ayelén Lizarraga, Patricia J. Johnson, Pablo H. Strobl-Mazzulla, Natalia de Miguel   +4 more
doaj   +1 more source

Dimer-dimer stacking interactions are important for nucleic acid binding by the archaeal chromatin protein Alba

, 2013
Archaea use a variety of small basic proteins to package their DNA. One of the most widespread and highly conserved is the Alba (Sso10b) protein. Alba interacts with both DNA and RNA in vitro, and we show in the present study that it binds more tightly ...
Petrovic-Stojanovska, Biljana, White, Malcolm F, Jelinska, Clare, Ingledew, W John   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Decoupling Epigenetic and Genetic Effects through Systematic Analysis of Gene Position

Cell Reports, 2013
Classic “position-effect” experiments repositioned genes near telomeres to demonstrate that the epigenetic landscape can dramatically alter gene expression.
Menzies Chen, Katherine Licon, Rei Otsuka, Lorraine Pillus, Trey Ideker   +4 more
doaj   +1 more source

Glycogen Synthase Kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells [PDF]

, 2014
Nuclear myosin 1c (NM1) mediates RNA polymerase I (pol I) transcription activation and cell cycle progression by facilitating PCAF-mediated H3K9 acetylation, but the molecular mechanism by which NM1 is regulated remains unclear.
Laura Borgonovo-Brandter (573527), Neus Visa (245920), Gothenburg University., Al-Muzzaini, Bader, Anne Von Euler, Von Euler Anne, Sarshad, Aishe A., Visa, Neus,, Laura Borgonovo-Brandter, Martin Corcoran (573526), Borgonovo-Brandter Laura, Martin Corcoran, Piergiorgio Percipalle (393101), Borgonovo-Brandter, Laura, Visa, Neus, Göteborgs universitet., Lamont, Douglas, Sarshad, Aishe A.,, Corcoran, Martin, Percipalle Piergiorgio, Von Euler, Anne, Percipalle, Piergiorgio, Al-Muzzaini Bader, Corcoran Martin, Visa Neus, Douglas Lamont (573529), Lamont Douglas, Aishe A Sarshad, Bader Al-Muzzaini, Anne Von Euler (573528), Sarshad Aishe A., Von Euler, Anne,, Bader Al-Muzzaini (393098), Douglas Lamont, Aishe A. Sarshad (573525), Neus Visa, Piergiorgio Percipalle   +36 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

A supervised learning framework for chromatin loop detection in genome-wide contact maps

Nature Communications, 2020
Predicting chromatin loops from genome-wide interaction matrices such as Hi-C data provides insight into gene regulation events. Here, the authors present Peakachu, a Random Forest classification framework that predicts chromatin loops from genome-wide ...
Tarik J. Salameh, Xiaotao Wang, Fan Song, Bo Zhang, Sage M. Wright, Chachrit Khunsriraksakul, Yijun Ruan, Feng Yue   +7 more
doaj   +1 more source

The nuclear pore complex : its role in chromatin structure and RNA export [PDF]

, 2015
Epigenetic regulation of gene expression is a relatively new and rapidly developing research field. It studies the mechanisms of regulation of gene expression, which although heritable, occur independently of changes in the DNA sequence and certainly aid
Hristova, Emilia
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source