Targeting of the SWI/SNF chromatin remodeling complex in cancer therapy
Успехи молекулярной онкологии, 2023 Chromatin remodeling is the one of the main epigenetic ways of gene expression regulation both in normal cells and in oncological diseases. Genes encoding protein subunits of SWI/ SNF remodeling complexes often mutate and/or change their expression in ...
M. V. Nemtsova, I. V. Bure
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DNA-encoded nucleosome occupancy is associated with transcription levels in the human malaria parasite Plasmodium falciparum. [PDF]
, 2014 BackgroundIn eukaryotic organisms, packaging of DNA into nucleosomes controls gene expression by regulating access of the promoter to transcription factors.
Bunnik, Evelien M +6 more
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ATP-dependent chromatin assembly is functionally distinct from chromatin remodeling
eLife, 2013 Chromatin assembly involves the combined action of ATP-dependent motor proteins and histone chaperones. Because motor proteins in chromatin assembly also function as chromatin remodeling factors, we investigated the relationship between ATP-driven ...
Sharon E Torigoe +4 more
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GBAF, a small BAF sub-complex with big implications: a systematic review
Epigenetics & Chromatin, 2020 ATP-dependent chromatin remodeling by histone-modifying enzymes and chromatin remodeling complexes is crucial for maintaining chromatin organization and facilitating gene transcription.
Sarah M. Innis, Birgit Cabot
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Snf2 family ATPases and DExx box helicases:differences and unifying concepts from high-resolution crystal structures [PDF]
, 2006 Proteins with sequence similarity to the yeast Snf2 protein form a large family of ATPases that act to alter the structure of a diverse range of DNA–protein structures including chromatin. Snf2 family enzymes are related in sequence to DExx box helicases,
Aasland +95 more
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Dynamic changes in ANGUSTIFOLIA3 complex composition reveal a growth regulatory mechanism in the maize leaf [PDF]
, 2015 Most molecular processes during plant development occur with a particular spatio-temporal specificity. Thus far, it has remained technically challenging to capture dynamic protein-protein interactions within a growing organ, where the interplay between ...
Aesaert, Stijn +17 more
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The human Cranio Facial Development Protein 1 (Cfdp1) gene encodes a protein required for the maintenance of higher-order chromatin organization [PDF]
, 2017 The human Cranio Facial Development Protein 1 (Cfdp1) gene maps to chromosome 16q22.2-q22.3 and encodes the CFDP1 protein, which belongs to the evolutionarily conserved Bucentaur (BCNT) family.
Atterrato, Maria Teresa +5 more
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The role of aTp-dependent chromatin remodeling factors in chromatin assembly in vivo
Вавиловский журнал генетики и селекции, 2019 Chromatin assembly is a fundamental process essential for chromosome duplication subsequent to DNA replication. In addition, histone removal and incorporation take place constantly throughout the cell cycle in the course of DNA-utilizing processes, such ...
Iu. A. Il’ina, A. Yu. Konev
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The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes. [PDF]
, 2009 Evenly spaced nucleosomes directly correlate with condensed chromatin and gene silencing. The ATP-dependent chromatin assembly factor (ACF) forms such structures in vitro and is required for silencing in vivo.
Acevedo, Ashley +8 more
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Non-mammalian model organisms in epigenetic research : an overview [PDF]
, 2020 Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik +3 more
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