Results 31 to 40 of about 578,337 (355)

PTEN in Chromatin Remodeling [PDF]

Cold Spring Harbor Perspectives in Medicine, 2019
The tumor suppressor phosphatase and tension homolog (PTEN) is frequently mutated in human cancers, and it functions in multiple ways to safeguard cells from tumorigenesis. In the cytoplasm, PTEN antagonizes the PI3K/AKT pathway and suppresses cellular proliferation and survival.
Jingyi, Yang, Yuxin, Yin
openaire   +2 more sources

The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling

Cells, 2019
Hippo signaling controls cellular processes that ultimately impact organogenesis and homeostasis. Consequently, disease states including cancer can emerge when signaling is deregulated.
Ryan E Hillmer, B. Link
semanticscholar   +1 more source

Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer

Leukemia, 2018
STAT3 and STAT5 proteins are oncogenic downstream mediators of the JAK–STAT pathway. Deregulated STAT3 and STAT5 signaling promotes cancer cell proliferation and survival in conjunction with other core cancer pathways.
B. Wingelhofer, H. Neubauer, P. Valent, Xiaonan Han, S. Constantinescu, P. Gunning, Mathias Müller, R. Moriggl   +7 more
semanticscholar   +1 more source

Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling

Cell Reports, 2020
Summary: The human genome encodes millions of regulatory elements, of which only a small fraction are active within a given cell type. Little is known about the global impact of chromatin remodelers on regulatory DNA landscapes and how this translates to
John E. Lazar, Sandra Stehling-Sun, Vivek Nandakumar, Hao Wang, Daniel R. Chee, Nicholas P. Howard, Reyes Acosta, Douglass Dunn, Morgan Diegel, Fidencio Neri, Andres Castillo, Sean Ibarrientos, Kristen Lee, Ninnia Lescano, Ben Van Biber, Jemma Nelson, Jessica Halow, Richard Sandstrom, Daniel Bates, Fyodor D. Urnov, Alister P.W. Funnell, John A. Stamatoyannopoulos   +21 more
doaj   +1 more source

Chromatin Remodeling and Epigenetic Regulation in Plant DNA Damage Repair

International Journal of Molecular Sciences, 2019
DNA damage response (DDR) in eukaryotic cells is initiated in the chromatin context. DNA damage and repair depend on or have influence on the chromatin dynamics associated with genome stability. Epigenetic modifiers, such as chromatin remodelers, histone
Jin-Hong Kim
semanticscholar   +1 more source

Chromatin Remodeling BAF (SWI/SNF) Complexes in Neural Development and Disorders

Frontiers in Molecular Neuroscience, 2017
The ATP-dependent BRG1/BRM associated factor (BAF) chromatin remodeling complexes are crucial in regulating gene expression by controlling chromatin dynamics.
G. Sokpor, Yuanbin Xie, Joachim Rosenbusch, Tran Tuoc   +3 more
semanticscholar   +1 more source

A Double-Edged Role for SIRT7 in Cancer: Can Anti-Cancer Immunity Tip the Balance?

Pharmaceuticals
Background/Objectives: Sirtuin 7 (SIRT7), a nuclear NAD+-dependent deacylase, plays multifaceted and sometimes opposing roles in tumorigenesis. By preserving chromatin architecture and genome integrity, SIRT7 protects against malignant transformation ...
Shahriar Tarighi, Zifan Ning, Andrés Gámez-García, Alejandro Vaquero, Thomas Braun, Alessandro Ianni   +5 more
doaj   +1 more source

The SIRT7-nucleolus connection in cancer: ARF enters the fray

Molecular & Cellular Oncology
The nucleolar enzyme sirtuin 7 (SIRT7) promotes cancer progression in certain malignancies, likely in part by controlling ribosome biosynthesis. Recently, we discovered that SIRT7 destabilizes the cyclin dependent kinase inhibitor 2A (CDKN2A, known as ...
Shahriar Tarighi, Poonam Kumari, Alejandro Vaquero, Thomas Braun, Alessandro Ianni   +4 more
doaj   +1 more source

Epigenetic regulation and chromatin remodeling in learning and memory

Experimental and Molecular Medicine, 2017
Understanding the underlying mechanisms of memory formation and maintenance has been a major goal in the field of neuroscience. Memory formation and maintenance are tightly controlled complex processes.
Somi Kim, B. Kaang
semanticscholar   +1 more source

Chromatin remodelling during development [PDF]

Nature, 2010
New methods for the genome-wide analysis of chromatin are providing insight into its roles in development and their underlying mechanisms. Current studies indicate that chromatin is dynamic, with its structure and its histone modifications undergoing global changes during transitions in development and in response to extracellular cues.
Lena, Ho, Gerald R, Crabtree
openaire   +2 more sources