Results 31 to 40 of about 539,283 (308)

Dynamic remodeling of individual nucleosomes across a eukaryotic genome in response to transcriptional perturbation. [PDF]

PLoS Biology, 2008
The eukaryotic genome is packaged as chromatin with nucleosomes comprising its basic structural unit, but the detailed structure of chromatin and its dynamic remodeling in terms of individual nucleosome positions has not been completely defined ...
Sushma Shivaswamy, Akshay Bhinge, Yongjun Zhao, Steven Jones, Martin Hirst, Vishwanath R Iyer   +5 more
doaj   +1 more source

Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes [PDF]

, 2006
ISWI proteins form the catalytic core of a subset of ATP-dependent chromatin remodelling activities in eukaryotes from yeast to man. Many of these complexes have been found to reposition nucleosomes, but with different directionalities.
Alen, Beard, Becker, Brehm, Bruno, Bruno, Davey, Dillingham, Drew, Eberharter, Elfring, Fazzio, Flaus, Flaus, Flaus, Hamiche, Kagalwala, Kang, Kassabov, Langst, Lorch, Lowary, Luger, Lusser, Meersseman, Mizuguchi, Morillon, Rigaut, Schnitzler, Tran, Tsukiyama, Tsukiyama, Vary, Zofall   +33 more
core   +4 more sources

Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila. [PDF]

, 2015
Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms in physiology and behavior with the 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping,
Chiu, Joanna C, Kwok, Rosanna S, Lam, Vu H   +2 more
core   +1 more source

Genome-wide analysis of interactions between ATP-dependent chromatin remodeling and histone modifications

BMC Genomics, 2009
Background ATP-dependent chromatin remodeling and the covalent modification of histones play central roles in determining chromatin structure and function.
Wang Jiang, Feng Jihua, Xiang Qian, Dai Xianhua, Dai Zhiming, Deng Yangyang, He Caisheng   +6 more
doaj   +1 more source

Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion

Scientific Reports, 2022
SARS-CoV-2 infection triggers profound and variable immune responses in human hosts. Chromatin remodeling has been observed in individuals severely ill or convalescing with COVID-19, but chromatin remodeling early in disease prior to anti-spike protein ...
Nicholas S. Giroux, Shengli Ding, Micah T. McClain, Thomas W. Burke, Elizabeth Petzold, Hong A. Chung, Grecia O. Rivera, Ergang Wang, Rui Xi, Shree Bose, Tomer Rotstein, Bradly P. Nicholson, Tianyi Chen, Ricardo Henao, Gregory D. Sempowski, Thomas N. Denny, Maria Iglesias De Ussel, Lisa L. Satterwhite, Emily R. Ko, Geoffrey S. Ginsburg, Bryan D. Kraft, Ephraim L. Tsalik, Xiling Shen, Christopher W. Woods   +23 more
doaj   +1 more source

Engineered Chromatin Remodeling Proteins for Precise Nucleosome Positioning

Cell Reports, 2019
Summary: Regulation of chromatin structure is essential for controlling access of DNA to factors that require association with specific DNA sequences. Here we describe the development and validation of engineered chromatin remodeling proteins (E-ChRPs ...
Drake A. Donovan, Johnathan G. Crandall, Orion G.B. Banks, Zena D. Jensvold, Vi Truong, Devin Dinwiddie, Laura E. McKnight, Jeffrey N. McKnight   +7 more
doaj   +1 more source

Basis of specificity for a conserved and promiscuous chromatin remodeling protein

eLife, 2021
Eukaryotic genomes are organized dynamically through the repositioning of nucleosomes. Isw2 is an enzyme that has been previously defined as a genome-wide, nonspecific nucleosome spacing factor.
Drake A Donovan, Johnathan G Crandall, Vi N Truong, Abigail L Vaaler, Thomas B Bailey, Devin Dinwiddie, Orion GB Banks, Laura E McKnight, Jeffrey N McKnight   +8 more
doaj   +1 more source

Epigenetic aberrations and cancer [PDF]

, 2006
The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core   +3 more sources

Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer

Leukemia, 2018
STAT3 and STAT5 proteins are oncogenic downstream mediators of the JAK–STAT pathway. Deregulated STAT3 and STAT5 signaling promotes cancer cell proliferation and survival in conjunction with other core cancer pathways.
B. Wingelhofer, H. Neubauer, P. Valent, Xiaonan Han, S. Constantinescu, P. Gunning, Mathias Müller, R. Moriggl   +7 more
semanticscholar   +1 more source

Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. [PDF]

, 2017
ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation.
Amaral, Maria Luisa, Benner, Christopher, Hargreaves, Diana C, Kelso, Timothy WR, Porter, Devin K, Shokhirev, Maxim N   +5 more
core   +1 more source