Results 61 to 70 of about 578,337 (355)
Genes & Development, 2017 Shapira et al. show that EBF2 physically interacts with the chromatin remodeler BRG1 and the BAF chromatin remodeling complex in brown adipocytes. They identified the histone reader protein DPF3 as a brown fat-selective component of the BAF complex that ...
Suzanne N. Shapira +7 more
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Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Chromatin remodeling and cancer, part II: ATP-dependent chromatin remodeling [PDF]
Trends in Molecular Medicine, 2007 Connections between perturbations that lie outside of our genome, that is, epigenetic alternations, and tumorigenesis have become increasingly apparent. Dynamic chromatin remodeling of the fundamental nucleosomal structure (covered in this review) or the covalent marks residing in the histone proteins that make up this structure (covered previously in ...
Gang G, Wang, C David, Allis, Ping, Chi
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YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Cell Reports, 2016 During DNA replication, chromatin must be disassembled and faithfully reassembled on newly synthesized genomes. The mechanisms that govern the assembly of chromatin structures following DNA replication are poorly understood.
Tejas Yadav, Iestyn Whitehouse
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Chromatin-remodeling links metabolic signaling to gene expression
Molecular Metabolism, 2020 Background: ATP-dependent chromatin remodelers are evolutionarily conserved complexes that alter nucleosome positioning to influence many DNA-templated processes, such as replication, repair, and transcription.
Ashby J. Morrison
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Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Remodeling chromatin for senescence [PDF]
Aging Cell, 2007 SummaryCellular senescence is an irreversible proliferation arrest that contributes to tumor suppression and, perhaps, tissue aging. Senescence is frequently accompanied by an increase in nuclear heterochromatin, which is thought to promote proliferation arrest. In this issue, Medrano and co‐workers describe new insights into the protein complexes that
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Science Advances, 2015 New human genetic findings paired with biochemical studies are challenging current thinking on the function of chromatin remodeling complexes. Over the past 4 years, nearly 100 exome sequencing studies have revealed the high frequency of mutations in the
Cigall Kadoch, G. Crabtree
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