The modular mechanism of chromocenter formation in Drosophila [PDF]
eLife, 2018 AbstractA central principle underlying the ubiquity and abundance of pericentromeric satellite DNA repeats in eukaryotes has remained poorly understood. In our previous study (Jagannathan et al., 2018), we proposed that the interchromosomal clustering of satellite DNAs into nuclear structures known as chromocenters ensures encapsulation of all ...
Madhav Jagannathan +2 more
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α-Crystalline Domains and Intrinsically Disordered Regions Can Work in Parallel to Induce Accumulation of MBD6 at Chromocenters in <i>Arabidopsis thaliana</i>. [PDF]
EpigenomesBoone BA +3 more
europepmc +3 more sources
DNA Environment of Centromeres and Non-Homologous Chromosomes Interactions in Mouse
Cells, 2021 Although the pericentromeric regions of chromosomes that are enriched in tandemly repeated satellite DNA represent a significant part of eukaryotic genomes, they remain understudied, which is mainly due to interdisciplinary knowledge gaps. Recent studies
Victor Spangenberg +5 more
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Author response: The modular mechanism of chromocenter formation in Drosophila
, 2019 Madhav Jagannathan +2 more
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PLoS Genetics, 2021 Reduction of genome ploidy from diploid to haploid necessitates stable pairing of homologous chromosomes into bivalents before the start of the first meiotic division.
Luisa Vernizzi, Christian F Lehner
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A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse. [PDF]
, 2012 Intragenomic conflicts arise when a genetic element favours its own transmission to the detriment of others. Conflicts over sex chromosome transmission are expected to have influenced genome structure, gene regulation, and speciation.
Affara, Nabeel A. +5 more
core +8 more sources
Spatial organization of fibroblast nuclear chromocenters: component tree analysis
Journal of Anatomy, 2013 AbstractThe nuclei of mouse connective tissue fibroblasts contain chromocenters which are well‐defined zones of heterochromatin that can be used as positional landmarks to examine nuclear remodeling in response to a mechanical perturbation. This study used component tree analysis, an image segmentation algorithm that detects high intensity voxels that ...
Robert R. Snapp +5 more
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ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. [PDF]
, 2009 Constitutive heterochromatin in Arabidopsis thaliana is marked by repressive chromatin modifications, including DNA methylation, histone H3 dimethylation at Lys9 (H3K9me2) and monomethylation at Lys27 (H3K27me1).
Bernatavichute, Yana V +9 more
core +1 more source
The modular mechanism of chromocenter formation in Drosophila
eLife, 2019 A central principle underlying the ubiquity and abundance of pericentromeric satellite DNA repeats in eukaryotes has remained poorly understood. Previously we proposed that the interchromosomal clustering of satellite DNAs into nuclear structures known ...
Madhav Jagannathan +2 more
doaj +1 more source
A conserved function for pericentromeric satellite DNA
eLife, 2018 A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown.
Madhav Jagannathan +2 more
doaj +1 more source