Results 181 to 190 of about 92,482 (260)

Epigenetic Modifications in Alternative Splicing of LDLR pre-mRNA on Hypercholesterolemia Following Aerobic Exercise Training. [PDF]

Int J Mol Sci
Zhao J, Yan P, Pang Y, Dong Y, Shi X.
europepmc   +1 more source

Role of intra‐individual variation in the detection of thresholds for DFI and for misclassification rates: A retrospective analysis of 14,775 SCSA® tests

Andrology, EarlyView.
Abstract Background Sperm DNA damage is associated with reduced male fertility after natural conception and intrauterine insemination. However, the impact on in vitro fertilization (IVF) and especially intracytoplasmic sperm injection (ICSI) treatments is still unclear.
Preben Christensen, Robert Fischer, Wolfgang Schulze, Vera Baukloh, Kimberly Kienast, Graham Coull, Erik T. Parner   +6 more
wiley   +1 more source

In vivo assembly of complete eukaryotic nucleosomes and (H3-H4)-only non-canonical nucleosomal particles in the model bacterium Escherichia coli. [PDF]

Commun Biol
Zhou X, Zhang N, Gong J, Zhang K, Chen P, Cheng X, Ye BC, Zhao G, Jing X, Li X.   +9 more
europepmc   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Molecular pathological insights into tumorigenesis and progression of giant cell tumor of bone. [PDF]

J Bone Oncol
Yao Y, Lee VKM, Chen ES.
europepmc   +1 more source

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, EarlyView.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

Molecular insight into histone methylation as a novel target for oral squamous cell carcinoma: future hope in personalised medicine. [PDF]

J Cancer
Rajendran P, Prasad M, Ali EM, Sekar R, AlZahrani AM, Karobari MI, Genena MAM, Abdallah BM.   +7 more
europepmc   +1 more source

In Vivo Reprogramming Highlights Epigenetic Regulation That Shapes Cancer Hallmarks

Cancer Science, EarlyView.
In this review, the authors first introduce genetic aberrations that cause cancer development. Then, they illustrate the impact of epigenetic abnormalities in cancer, especially with reference to studies that use in vivo reprogramming technologies. Finally, the authors discuss the importance of histological evaluations of tumor tissue to understand non‐
Yosuke Yamada, Nao Sankoda, Yasuhiro Yamada   +2 more
wiley   +1 more source

RNA Pol-II transcripts in nucleolar associated domains of cancer cell nucleoli. [PDF]

Nucleus
Chowdhury SR, Shilpi A, Felsenfeld G.
europepmc   +1 more source

Steroid‐Modulated Transcription Synergistically Forms DNA Double‐Strand Breaks With Topoisomerase II Inhibitor

Cancer Science, EarlyView.
Through our exploration of the synergistic effects of drug combinations for potential clinical applications, we found that steroids potentiate the anticancer effects of etoposide, a topoisomerase II inhibitor. Steroids, when combined with etoposide, increase DNA double‐strand breaks not via DNA repair inhibition but transcriptional modulation ...
Ying Zhao, Tetsuro Hisayoshi, Doudou Zhang, Saaya Suzuki, Takashi Watanabe, Atsuo Kobayashi, Qianqian Guo, Yukihide Momozawa, Takashi Shimokawa, Shunsuke Kato, Yoshio Miki, Shigeaki Sunada   +11 more
wiley   +1 more source