Results 191 to 200 of about 92,482 (260)

Follicular metabolic dysfunction, oocyte aneuploidy and ovarian aging: a review. [PDF]

J Ovarian Res
Wu D, Liu C, Ding L.
europepmc   +1 more source

Identification of a Distal Enhancer That Regulates TGF‐β–Induced SNAI1 Expression

Cancer Science, EarlyView.
In TGF‐β–stimulated cells, the activated Smad complex composed of Smad3 and Smad4 associates with the distal super enhancer region 2 (DSE2) and enhances its interaction with the SNAI1 proximal promoter, thus inducing SNAI1 expression. RREB1 regulates the basal activity of the enhancer but not its inducibility by TGF‐β.
Hao Fu, Yuka Itoh, Tomoe Sawaguchi, Shigeo Otake, Chiho Omata, Masao Saitoh, Keiji Miyazawa   +6 more
wiley   +1 more source

From Genes to Clinical Practice: Exploring the Genomic Underpinnings of Endometrial Cancer. [PDF]

Cancers (Basel)
Molefi T, Mabonga L, Hull R, Sebitloane M, Dlamini Z.   +4 more
europepmc   +1 more source

The Role of Histone Methyltransferase SETDB1 in Normal and Malignant Hematopoiesis

Cancer Science, EarlyView.
In this review, we discuss the role of SETDB1 in gene regulation, including an overview of its structural features and key cofactors. We also highlight the lineage‐specific roles of SETDB1 in both normal hematopoietic processes and hematological malignancies, emphasizing its function as an immune checkpoint molecule that suppresses natural killer cell ...
Yu‐Hsuan Chang, Susumu Goyama
wiley   +1 more source

Acute myeloid leukemia with <i>DEK::NUP214</i> fusion resembling acute promyelocytic leukemia, initially presenting as sweet syndrome: A case report and literature review. [PDF]

J Int Med Res
Liu H, Liu GX, Liu FH, Wang SG.
europepmc   +1 more source

Tasks and Visual Abstractions for 3D Chromatin Representation

Computer Graphics Forum, EarlyView.
Abstract The spatial organization of chromatin fiber directly influences its function. However, the high visual complexity of chromatin spatial models makes the understanding of the structure extremely challenging. Therefore, genomic researchers still primarily rely on indirect analysis of chromatin through 2D views, missing the advantages that 3D ...
A. Rychlý, J. Byška, B. Kozlíková, K. Furmanová   +3 more
wiley   +1 more source

Endometrial Aging and Reproductive Decline: The Central Role of Mitochondrial Dysfunction. [PDF]

Int J Mol Sci
Kobayashi H, Nishio M, Umetani M, Shigetomi H, Imanaka S, Hashimoto H.   +5 more
europepmc   +1 more source

HN1 Functions in Protein Synthesis Regulation via mTOR‐RPS6 Axis and Maintains Nucleolar Integrity

Cell Proliferation, EarlyView.
HN1 is required for nucleolar homeostasis which is the site of ribosome biogenesis and protein synthesis when its mRNA is knocked down by shRNA, it depletes in cytoplasm and the protein synthesis is downregulated in comparison to controls. Thus, the proliferating cells requiring vast number of nucleosomes, are arrested at S onset.
Gülseren Özduman, Aadil Javed, Azime Akçaöz Alasar, Bünyamin Akgül, Kemal Sami Korkmaz   +4 more
wiley   +1 more source

Emerging Roles for Transcription Factors During Mitosis. [PDF]

Cells
Flashner S, Azizkhan-Clifford J.
europepmc   +1 more source

Testis‐Specific PDHA2 Is Required for Proper Meiotic Recombination and Chromosome Organisation During Spermatogenesis

Cell Proliferation, EarlyView.
PDHA2, a testis‐specific subunit of pyruvate dehydrogenase, is required for the conversion of pyruvate to acetyl‐CoA. Its absence results in decreased acetyl‐CoA and precursors for metabolites and energy during spermatogenesis. This results in decreased histone acetylation, defective chromosome structure and moderately reduced crossovers, ultimately ...
Guoqiang Wang, Kailun Fang, Yongliang Shang, Xu Zhou, Qiqi Shao, Si Li, Ping Wang, Charlie Degui Chen, Liangran Zhang, Shunxin Wang   +9 more
wiley   +1 more source