Results 31 to 40 of about 10,432 (143)

Mapping chromatin interactions by chromosome conformation capture

, 2011
Chromosome conformation capture (3C) is one of the only techniques that allows for analysis of an intermediate level of chromosome structure ranging from a few to hundreds of kilobases, a level most relevant for gene regulation.
Dekker, Job, Dostie, Josee, Gheldof, Nele, Tabuchi, Tomoko M., Miele, Adriana   +4 more
core   +1 more source

Hypergraph Analysis Toolbox for Chromosome Conformation

, 2022
Recent advances in biological technologies, such as multi-way chromosome conformation capture (3C), require development of methods for analysis of multi-way interactions.
Indika Rajapakse, Stansbury, Cooper, Chen, Can, Rajapakse, Indika, Salman, Rahmy, Amit Surana, Cooper Stansbury, Joshua Pickard, Pickard, Joshua, Bloch, Anthony, Sion Kim, Kim, Sion, Surana, Amit, Anthony Bloch, Can Chen, Rahmy Salman   +15 more
core   +1 more source

Chromosome Conformation Capture Carbon Copy (5C) in Budding Yeast

, 2015
Chromosome conformation capture carbon copy (5C) is a high-throughput method for detecting ligation products of interest in a chromosome conformation capture (3C) library.
Dekker, Job, Belton, Jon-Matthew
core   +1 more source

Chromosome conformation capture in primary human cells

, 2016
3D organization of the genome, its structural and regulatory function of cell identity, is acquiring prominent features in epigenetics studies; more efforts have been done to develop techniques that allow studying nuclear structure.
Bodega B., Cortesi A.
core   +1 more source

High-resolution analysis of chromosome conformation in hyperthermophilic archaea

, 2021
Summary: Chromosome conformation capture (3C) techniques are emerging as promising approaches to study genome organization in Archaea, the least understood domain of life in terms of chromosome biology. Here, we describe a 3C technique combined with deep
Naomichi Takemata, Stephen D. Bell
core   +1 more source

Computational methods for analyzing genome-wide chromosome conformation capture data

, 2018
In all organisms, chromatin is packed to fulfil structural constraints and functional requirements. The hierarchical model of chromatin organization in the 3D nuclear space encompasses different topologies at diverse scale lengths, with chromosomes ...
Nicoletti, Chiara, Silvio Bicciato, Forcato, Mattia, Chiara Nicoletti, Bicciato, Silvio, Mattia Forcato   +5 more
core   +1 more source

Low-input Capture-C: A Chromosome Conformation Capture Assay to Analyze Chromatin Architecture in Small Numbers of Cells

, 2017
Chromosome conformation capture (3C) techniques are crucial to understanding tissue-specific regulation of gene expression, but current methods generally require large numbers of cells.
Downes, DJ, Downes, D., Downes, Damien J., A. Marieke Oudelaar, Hughes, J., Davies, James O.J., Oudelaar, AM, Hughes, JR, Oudelaar, A., Damien Downes, Hughes, James, Oudelaar, Aukje M., James Davies, Davies, JOJ, Davies, J., Jim Hughes   +15 more
core   +1 more source

Hi-C 3.0: Improved Protocol for Genome-Wide Chromosome Conformation Capture

, 2022
The intricate folding of chromatin enables living organisms to store genomic material in an extremely small volume while facilitating proper cell function.
Yang, Liyan, Dekker, Job, Lafontaine, Denis L., Gibcus, Johan H   +3 more
core   +1 more source

Detecting long-range chromatin interactions using the chromosome conformation capture sequencing (4C-seq) method

, 2011
Eukaryotic transcription is tightly regulated by transcriptional regulatory elements, even though these elements may be located far away from their target genes. It is now widely recognized that these regulatory elements can be brought in close proximity
Reymond, Alexandre, Leleu, Marion, Rougemont, J., Marion Leleu, Gheldof, N., Noordermeer, Daan, Reymond, A., Jacques Rougemont, Nele Gheldof, Noordermeer, D., Gheldof, Nele, Rougemont, Jacques, Daan Noordermeer, Alexandre Reymond, Leleu, M.   +14 more
core   +1 more source

Technical Review: A Hitchhiker’s Guide to Chromosome Conformation Capture

, 2017
International audienceThe introduction of chromosome conformation capture (3C) technologies boosted the field of 3D-genome research and significantly enhanced the available toolset to study chromosomal architecture.
Giacomo Cavalli, Stefan Grob, Grob, Stefan, Cavalli, Giacomo   +3 more
core   +1 more source