Results 31 to 40 of about 1,593,998 (268)

Tethered Chromosome Conformation Capture Sequencing in Triticeae: A Valuable Tool for Genome Assembly

Bio-Protocol, 2018
Chromosome conformation capture sequencing (Hi-C) is a powerful method to comprehensively interrogate the three-dimensional positioning of chromatin in the nucleus.
Axel Himmelbach, Ines Walde, Martin Mascher, Nils Stein   +3 more
doaj   +1 more source

Novel insights into chromosomal conformations in cancer

Molecular Cancer, 2017
Exploring gene function is critical for understanding the complexity of life. DNA sequences and the three-dimensional organization of chromatin (chromosomal interactions) are considered enigmatic factors underlying gene function, and interactions between
Ruobing Jia, Peiwei Chai, He Zhang, Xianqun Fan   +3 more
doaj   +1 more source

Comparative analysis of T4 DNA ligases and DNA polymerases used in chromosome conformation capture assays

BioTechniques, 2015
Three-dimensional (3-D) genome organization in the nuclear space affects various genomic functions. Circular chromosome conformation capture (4C-seq) is a powerful technique that allows researchers to measure long-range chromosomal interactions with a ...
Michal Schwartz, Avital Sarusi, Rachel T. Deitch, Moran Tal, Dana Raz, Myong-Hee Sung, Tommy Kaplan, Ofir Hakim   +7 more
doaj   +1 more source

Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data. [PDF]

PLoS Computational Biology, 2016
Chromosome conformation capture (3C) techniques have revealed many fascinating insights into the spatial organization of genomes. 3C methods typically provide information about chromosomal contacts in a large population of cells, which makes it difficult
Simeon Carstens, Michael Nilges, Michael Habeck   +2 more
doaj   +1 more source

Systematic evaluation of chromosome conformation capture assays

, 2021
Chromosome conformation capture (3C) assays are used to map chromatin interactions genome-wide. Chromatin interaction maps provide insights into the spatial organization of chromosomes and the mechanisms by which they fold.
Maehr, Rene, Abraham, Sameer, Genga, Ryan MJ, Mirny, Leonid A, Oomen, Marlies E, Nand, Ankita, Rando, Oliver J, Yang, Liyan, Mao, Hui, Dekker, Job, Krietenstein, Nils, Akgol Oksuz, Betul, Parsi, Krishna Mohan, Gibcus, Johan H, Venev, Sergey V, Ozadam, Hakan, Hakan Ozadam, Ankita Nand, Rene Maehr, Krishna Mohan Parsi, Hui Mao, Betul Akgol Oksuz, Oliver J. Rando, Liyan Yang, Sameer Abraham, Nils Krietenstein, Johan H. Gibcus, Ryan M. J. Genga, Sergey V. Venev, Leonid A. Mirny, Job Dekker, Marlies E. Oomen   +31 more
core   +1 more source

tRNA gene identity affects nuclear positioning. [PDF]

PLoS ONE, 2011
The three-dimensional organization of genomes is dynamic and plays a critical role in the regulation of cellular development and phenotypes. Here we use proximity-based ligation methods (i.e.
Chris D M Rodley, Dave A Pai, Tyrone A Mills, David R Engelke, Justin M O'Sullivan   +4 more
doaj   +1 more source

Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis

Frontiers in Genetics, 2023
Ankylosing Spondylitis (AS) is a chronic inflammatory arthritis of the spine exhibiting a strong genetic background. The mechanistic and functional understanding of the AS-associated genomic loci, identified with Genome Wide Association Studies (GWAS ...
Connor Davidson, Connor Davidson, B. Paul Wordsworth, Carla J. Cohen, Carla J. Cohen, Julian C. Knight, Matteo Vecellio, Matteo Vecellio   +7 more
doaj   +1 more source

The macro and micro of chromosome conformation capture

, 2021
The 3D organization of the genome facilitates gene regulation, replication, and repair, making it a key feature of genomic function and one that remains to be properly understood.
Hansen, Anders S, Viraat Y. Goel, Goel, Viraat Y, Anders S. Hansen   +3 more
core   +1 more source

Determining the Three-dimensional Structure of Genomes and Genomic Domains Integrating Chromosome Conformation Capture Data and Microscopy Images [PDF]

, 2023
[eng] Microscopy and Chromosome Conformation Capture (3C) are the two main techniques for studying the three-dimensional (3D) organization of the genome.
Castillo Andreo, David
core   +5 more sources

Insights about genome function from spatial organization of the genome

Human Genomics, 2018
Over the last 15 years, development of chromosome conformation capture (3C) and its subsequent high-throughput variants in conjunction with the fast development of sequencing technology has allowed investigators to generate large volumes of data giving ...
Shuvra Shekhar Roy, Ananda Kishore Mukherjee, Shantanu Chowdhury   +2 more
doaj   +1 more source